abnormal basophil morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size; these cells contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation (Mammalian Phenotype Ontology, MP_0002422)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002422
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Genes

14 gene mutations causing the abnormal basophil morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALOX15 arachidonate 15-lipoxygenase
ARNTL aryl hydrocarbon receptor nuclear translocator-like
CPA3 carboxypeptidase A3 (mast cell)
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPRC5C G protein-coupled receptor, class C, group 5, member C
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL21R interleukin 21 receptor
IL4 interleukin 4
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LYN LYN proto-oncogene, Src family tyrosine kinase
TBK1 TANK-binding kinase 1