abnormal b-1 b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity (Mammalian Phenotype Ontology, MP_0004976)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004976
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Genes

70 gene mutations causing the abnormal b-1 b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP11C ATPase, class VI, type 11C
AVPR1A arginine vasopressin receptor 1A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL10 B-cell CLL/lymphoma 10
BLNK B-cell linker
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD22 CD22 molecule
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DLL1 delta-like 1 (Drosophila)
DOCK8 dedicator of cytokinesis 8
EBF1 early B-cell factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCMR Fc fragment of IgM receptor
FNIP1 folliculin interacting protein 1
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HAX1 HCLS1 associated protein X-1
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IRF8 interferon regulatory factor 8
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MIR150 microRNA 150
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NOTCH2 notch 2
PAX5 paired box 5
PDCD1 programmed cell death 1
PFDN1 prefoldin subunit 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLCL2 phospholipase C-like 2
POU2F2 POU class 2 homeobox 2
PRKCB protein kinase C, beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFN stratifin
SH2B2 SH2B adaptor protein 2
SH3BP2 SH3-domain binding protein 2
SIAE sialic acid acetylesterase
SIGLEC10 sialic acid binding Ig-like lectin 10
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
THEMIS thymocyte selection associated
TLR8 toll-like receptor 8
VAV1 vav 1 guanine nucleotide exchange factor
ZEB1 zinc finger E-box binding homeobox 1