abnormal b-1 b cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas (Mammalian Phenotype Ontology, MP_0004940)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004940
Similar Terms
Downloads & Tools

Genes

71 gene mutations causing the abnormal b-1 b cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP11C ATPase, class VI, type 11C
AVPR1A arginine vasopressin receptor 1A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL10 B-cell CLL/lymphoma 10
BLNK B-cell linker
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD22 CD22 molecule
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DLL1 delta-like 1 (Drosophila)
DOCK8 dedicator of cytokinesis 8
EBF1 early B-cell factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCMR Fc fragment of IgM receptor
FNIP1 folliculin interacting protein 1
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HAX1 HCLS1 associated protein X-1
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IRF8 interferon regulatory factor 8
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MIR150 microRNA 150
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NOTCH2 notch 2
PAX5 paired box 5
PDCD1 programmed cell death 1
PFDN1 prefoldin subunit 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLCL2 phospholipase C-like 2
POU2F2 POU class 2 homeobox 2
PRKCB protein kinase C, beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFN stratifin
SH2B2 SH2B adaptor protein 2
SH3BP2 SH3-domain binding protein 2
SIAE sialic acid acetylesterase
SIGLEC10 sialic acid binding Ig-like lectin 10
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
THEMIS thymocyte selection associated
TLR8 toll-like receptor 8
VAV1 vav 1 guanine nucleotide exchange factor
ZEB1 zinc finger E-box binding homeobox 1