abnormal b cell activation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific (Mammalian Phenotype Ontology, MP_0008217)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008217
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Genes

141 gene mutations causing the abnormal b cell activation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CARD11 caspase recruitment domain family, member 11
CCND3 cyclin D3
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD22 CD22 molecule
CD300C CD300c molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD80 CD80 molecule
CD81 CD81 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CR2 complement component (3d/Epstein Barr virus) receptor 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCLRE1C DNA cross-link repair 1C
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTX1 deltex 1, E3 ubiquitin ligase
ELF4 E74-like factor 4 (ets domain transcription factor)
ERCC1 excision repair cross-complementation group 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GABPB2 GA binding protein transcription factor, beta subunit 2
GAPT GRB2-binding adaptor protein, transmembrane
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPR132 G protein-coupled receptor 132
HRH1 histamine receptor H1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL12RB2 interleukin 12 receptor, beta 2
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
LAT linker for activation of T cells
LIG4 ligase IV, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LY86 lymphocyte antigen 86
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
ORAI1 ORAI calcium release-activated calcium modulator 1
OTUD7B OTU deubiquitinase 7B
PARP14 poly (ADP-ribose) polymerase family, member 14
PAWR PRKC, apoptosis, WT1, regulator
PDCD1 programmed cell death 1
PELI1 pellino E3 ubiquitin protein ligase 1
PFDN1 prefoldin subunit 1
PGAP3 post-GPI attachment to proteins 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKN1 protein kinase N1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
PNP purine nucleoside phosphorylase
POLM polymerase (DNA directed), mu
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOG ras homolog family member G
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S1PR2 sphingosine-1-phosphate receptor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFN stratifin
SH3BP2 SH3-domain binding protein 2
SIAE sialic acid acetylesterase
SKAP2 src kinase associated phosphoprotein 2
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
SPTA1 spectrin, alpha, erythrocytic 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TERC telomerase RNA component
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
WIPF1 WAS/WASL interacting protein family, member 1
ZEB1 zinc finger E-box binding homeobox 1