abnormal antigen presentation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberration in the process by which by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex (Mammalian Phenotype Ontology, MP_0001835)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001835
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Genes

63 gene mutations causing the abnormal antigen presentation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
B2M beta-2-microglobulin
BATF3 basic leucine zipper transcription factor, ATF-like 3
CCR6 chemokine (C-C motif) receptor 6
CD1D CD1d molecule
CD40LG CD40 ligand
CD68 CD68 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CIITA class II, major histocompatibility complex, transactivator
CLEC4D C-type lectin domain family 4, member D
CLEC9A C-type lectin domain family 9, member A
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSD cathepsin D
CTSE cathepsin E
CTSS cathepsin S
ERAP1 endoplasmic reticulum aminopeptidase 1
FCAMR Fc receptor, IgA, IgM, high affinity
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLT3 fms-related tyrosine kinase 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IL10 interleukin 10
IL13 interleukin 13
IL2 interleukin 2
IL4 interleukin 4
IL6ST interleukin 6 signal transducer
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
NUP98 nucleoporin 98kDa
PDCD1LG2 programmed cell death 1 ligand 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
RAG1 recombination activating gene 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SKAP2 src kinase associated phosphoprotein 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPP2 tripeptidyl peptidase II
UNC93B1 unc-93 homolog B1 (C. elegans)
WAS Wiskott-Aldrich syndrome
XCR1 chemokine (C motif) receptor 1