abnormal angiogenesis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network (Mammalian Phenotype Ontology, MP_0000260)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000260
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Genes

270 gene mutations causing the abnormal angiogenesis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABI1 abl-interactor 1
ABRA actin binding Rho activating protein
ACVRL1 activin A receptor type II-like 1
ADAM10 ADAM metallopeptidase domain 10
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADGRA2 adhesion G protein-coupled receptor A2
ADM adrenomedullin
AGER advanced glycosylation end product-specific receptor
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AIP aryl hydrocarbon receptor interacting protein
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMOT angiomotin
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
ANXA2 annexin A2
APH1A APH1A gamma secretase subunit
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ATE1 arginyltransferase 1
ATF2 activating transcription factor 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIRC6 baculoviral IAP repeat containing 6
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CCDC88A coiled-coil domain containing 88A
CCL13 chemokine (C-C motif) ligand 13
CCM2 cerebral cavernous malformation 2
CCM2L cerebral cavernous malformation 2-like
CD151 CD151 molecule (Raph blood group)
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CHD7 chromodomain helicase DNA binding protein 7
CHM choroideremia (Rab escort protein 1)
CHRD chordin
CLIC4 chloride intracellular channel 4
CREBBP CREB binding protein
CRHR2 corticotropin releasing hormone receptor 2
CTGF connective tissue growth factor
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DICER1 dicer 1, ribonuclease type III
DLL4 delta-like 4 (Drosophila)
DSTN destrin (actin depolymerizing factor)
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
EGFL7 EGF-like-domain, multiple 7
ELN elastin
ENG endoglin
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
EPHB4 EPH receptor B4
EPO erythropoietin
EPOR erythropoietin receptor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESAM endothelial cell adhesion molecule
ETV2 ets variant 2
F11R F11 receptor
FBLN5 fibulin 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF8 fibroblast growth factor 8 (androgen-induced)
FLNA filamin A, alpha
FLNB filamin B, beta
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXC1 forkhead box C1
FOXC2 forkhead box C2
FOXH1 forkhead box H1
FOXO1 forkhead box O1
FURIN furin (paired basic amino acid cleaving enzyme)
FZD4 frizzled class receptor 4
G6PD glucose-6-phosphate dehydrogenase
GBX2 gastrulation brain homeobox 2
GIPC1 GIPC PDZ domain containing family, member 1
GLI3 GLI family zinc finger 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPC3 glypican 3
GPR4 G protein-coupled receptor 4
H2AFX H2A histone family, member X
HAND2 heart and neural crest derivatives expressed 2
HDAC7 histone deacetylase 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXA13 homeobox A13
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPSE heparanase
HSPG2 heparan sulfate proteoglycan 2
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNGR1 interferon gamma receptor 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL12RB2 interleukin 12 receptor, beta 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
ISL1 ISL LIM homeobox 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB8 integrin, beta 8
KAT6A K(lysine) acetyltransferase 6A
KAT7 K(lysine) acetyltransferase 7
KDR kinase insert domain receptor
KLF15 Kruppel-like factor 15
KLF5 Kruppel-like factor 5 (intestinal)
KRIT1 KRIT1, ankyrin repeat containing
LEF1 lymphoid enhancer-binding factor 1
LEMD3 LEM domain containing 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP1 latent transforming growth factor beta binding protein 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MB myoglobin
MED1 mediator complex subunit 1
MED24 mediator complex subunit 24
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MFGE8 milk fat globule-EGF factor 8 protein
MIB1 mindbomb E3 ubiquitin protein ligase 1
MKL2 MKL/myocardin-like 2
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPI mannose phosphate isomerase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYH9 myosin, heavy chain 9, non-muscle
MYO18B myosin XVIIIB
MYOCD myocardin
NCF1 neutrophil cytosolic factor 1
NGFR nerve growth factor receptor
NKX2-5 NK2 homeobox 5
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOSTRIN nitric oxide synthase trafficking
NOTCH1 notch 1
NOTCH3 notch 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRARP NOTCH-regulated ankyrin repeat protein
NRP1 neuropilin 1
NUMB numb homolog (Drosophila)
OVOL2 ovo-like zinc finger 2
PAM peptidylglycine alpha-amidating monooxygenase
PARVA parvin, alpha
PAX3 paired box 3
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PFKM phosphofructokinase, muscle
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITX2 paired-like homeodomain 2
PKNOX1 PBX/knotted 1 homeobox 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLG plasminogen
PLXND1 plexin D1
PNPLA6 patatin-like phospholipase domain containing 6
POGLUT1 protein O-glucosyltransferase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRDM1 PR domain containing 1, with ZNF domain
PRDM6 PR domain containing 6
PSEN1 presenilin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRJ protein tyrosine phosphatase, receptor type, J
PXN paxillin
QKI QKI, KH domain containing, RNA binding
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAP1A RAP1A, member of RAS oncogene family
RASIP1 Ras interacting protein 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RDH10 retinol dehydrogenase 10 (all-trans)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RIPPLY3 ripply transcriptional repressor 3
RNF7 ring finger protein 7
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RORA RAR-related orphan receptor A
RRAS related RAS viral (r-ras) oncogene homolog
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SCX scleraxis basic helix-loop-helix transcription factor
SDC4 syndecan 4
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHARPIN SHANK-associated RH domain interactor
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMAD2 SMAD family member 2
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STK11 serine/threonine kinase 11
STRAP serine/threonine kinase receptor associated protein
T T, brachyury homolog (mouse)
TAL1 T-cell acute lymphocytic leukemia 1
TBX1 T-box 1
TBX18 T-box 18
TBX2 T-box 2
TBX4 T-box 4
TBX6 T-box 6
TDG thymine-DNA glycosylase
TEK TEK tyrosine kinase, endothelial
TERC telomerase RNA component
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLL1 tolloid-like 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TP53 tumor protein p53
TTN titin
UBP1 upstream binding protein 1 (LBP-1a)
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VASH1 vasohibin 1
VASH2 vasohibin 2
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VEZF1 vascular endothelial zinc finger 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WASF2 WAS protein family, member 2
WNK1 WNK lysine deficient protein kinase 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1