abnormal adenoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy (Mammalian Phenotype Ontology, MP_0020189)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020189
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Genes

94 gene mutations causing the abnormal adenoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
AIP aryl hydrocarbon receptor interacting protein
APC adenomatous polyposis coli
ATM ATM serine/threonine kinase
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BECN1 beclin 1, autophagy related
BHLHA15 basic helix-loop-helix family, member a15
BHMT betaine--homocysteine S-methyltransferase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG3 BTG family, member 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASC1 cancer susceptibility candidate 1
CBX7 chromobox homolog 7
CCNDBP1 cyclin D-type binding-protein 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDX2 caudal type homeobox 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL9 cullin 9
DCC DCC netrin 1 receptor
DCLRE1A DNA cross-link repair 1A
DRD2 dopamine receptor D2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERRFI1 ERBB receptor feedback inhibitor 1
EXO1 exonuclease 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FANCD2 Fanconi anemia, complementation group D2
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2IRD1 GTF2I repeat domain containing 1
HELQ helicase, POLQ-like
IL6ST interleukin 6 signal transducer
ING2 inhibitor of growth family, member 2
KITLG KIT ligand
KRAS Kirsten rat sarcoma viral oncogene homolog
LZTS1 leucine zipper, putative tumor suppressor 1
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MUS81 MUS81 structure-specific endonuclease subunit
NBN nibrin
NKX2-8 NK2 homeobox 8
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUAK2 NUAK family, SNF1-like kinase, 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PAX6 paired box 6
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRL prolactin
PTEN phosphatase and tensin homolog
PTPRT protein tyrosine phosphatase, receptor type, T
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RET ret proto-oncogene
RINT1 RAD50 interactor 1
SMAD4 SMAD family member 4
SMAD9 SMAD family member 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SSBP2 single-stranded DNA binding protein 2
STK11 serine/threonine kinase 11
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
THRB thyroid hormone receptor, beta
TLR2 toll-like receptor 2
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
USP44 ubiquitin specific peptidase 44
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C