abnormal acute inflammation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response (Mammalian Phenotype Ontology, MP_0002498)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002498
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Genes

273 gene mutations causing the abnormal acute inflammation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
AHR aryl hydrocarbon receptor
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA5 annexin A5
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APCS amyloid P component, serum
APOE apolipoprotein E
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF2 activating transcription factor 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCR breakpoint cluster region
BDKRB1 bradykinin receptor B1
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
C3AR1 complement component 3a receptor 1
CASP12 caspase 12 (gene/pseudogene)
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCKBR cholecystokinin B receptor
CCL13 chemokine (C-C motif) ligand 13
CCL17 chemokine (C-C motif) ligand 17
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD14 CD14 molecule
CD1D CD1d molecule
CD207 CD207 molecule, langerin
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CD83 CD83 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CISH cytokine inducible SH2-containing protein
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLIC4 chloride intracellular channel 4
CMKLR1 chemerin chemokine-like receptor 1
CPA3 carboxypeptidase A3 (mast cell)
CPN1 carboxypeptidase N, polypeptide 1
CREB3L3 cAMP responsive element binding protein 3-like 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL6 chemokine (C-X-C motif) ligand 6
CYBB cytochrome b-245, beta polypeptide
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
ECM1 extracellular matrix protein 1
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB6 EPH receptor B6
F11R F11 receptor
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FES FES proto-oncogene, tyrosine kinase
FLG filaggrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GCA grancalcin, EF-hand calcium binding protein
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GFI1 growth factor independent 1 transcription repressor
GGT5 gamma-glutamyltransferase 5
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR34 G protein-coupled receptor 34
HLA-DMA major histocompatibility complex, class II, DM alpha
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPGDS hematopoietic prostaglandin D synthase
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL22 interleukin 22
IL25 interleukin 25
IL27 interleukin 27
IL3 interleukin 3
IL33 interleukin 33
IL34 interleukin 34
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUND jun D proto-oncogene
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAPTM5 lysosomal protein transmembrane 5
LAT2 linker for activation of T cells family, member 2
LBP lipopolysaccharide binding protein
LEP leptin
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LITAF lipopolysaccharide-induced TNF factor
LPAR2 lysophosphatidic acid receptor 2
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MILR1 mast cell immunoglobulin-like receptor 1
MIR223 microRNA 223
MME membrane metallo-endopeptidase
MMP19 matrix metallopeptidase 19
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MST1R macrophage stimulating 1 receptor
NCF1 neutrophil cytosolic factor 1
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRC3 NLR family, CARD domain containing 3
NLRP10 NLR family, pyrin domain containing 10
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NTAN1 N-terminal asparagine amidase
ORAI1 ORAI calcium release-activated calcium modulator 1
OTC ornithine carbamoyltransferase
PARG poly (ADP-ribose) glycohydrolase
PARP1 poly (ADP-ribose) polymerase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGF placental growth factor
PIAS1 protein inhibitor of activated STAT, 1
PILRA paired immunoglobin-like type 2 receptor alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G2D phospholipase A2, group IID
PLA2G3 phospholipase A2, group III
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G5 phospholipase A2, group V
PLA2R1 phospholipase A2 receptor 1, 180kDa
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCD protein kinase C, delta
PTAFR platelet-activating factor receptor
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGES2 prostaglandin E synthase 2
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAG2 recombination activating gene 2
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS13 regulator of G-protein signaling 13
RGS3 regulator of G-protein signaling 3
RHOH ras homolog family member H
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLPI secretory leukocyte peptidase inhibitor
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SRXN1 sulfiredoxin 1
SSTR4 somatostatin receptor 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIM1 stromal interaction molecule 1
STIP1 stress-induced phosphoprotein 1
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBK1 TANK-binding kinase 1
TBXA2R thromboxane A2 receptor
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
THBD thrombomodulin
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRADD TNFRSF1A-associated via death domain
TRAFD1 TRAF-type zinc finger domain containing 1
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIP10 thyroid hormone receptor interactor 10
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D3 TSC22 domain family, member 3
TSLP thymic stromal lymphopoietin
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
USP18 ubiquitin specific peptidase 18
VAMP8 vesicle-associated membrane protein 8
VIPR2 vasoactive intestinal peptide receptor 2
ZC3H12A zinc finger CCCH-type containing 12A