Waist-Hip Ratio Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description The waist circumference measurement divided by the hip circumference measurement. For both men and women, a waist-to-hip ratio (WHR) of 1.0 or higher is considered at risk for undesirable health consequences, such as heart disease and ailments associated with OVERWEIGHT. A healthy WHR is 0.90 or less for men, and 0.80 or less for women. (National Center for Chronic Disease Prevention and Health Promotion, 2004) (Experimental Factor Ontology, EFO_0004343)
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Genes

93 genes associated with the trait Waist-Hip Ratio in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
RSPO3 R-spondin 3 1.71516
TBX15 T-box 15 1.54834
DNM3 dynamin 3 1.31165
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.02102
ZNRF3 zinc and ring finger 3 0.982475
NISCH nischarin 0.897125
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.836775
FTO fat mass and obesity associated 0.711358
BTNL2 butyrophilin-like 2 0.567219
MACROD2 MACRO domain containing 2 0.516577
ANLN anillin, actin binding protein 0.502428
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.460974
EDDM3DP epididymal protein 3D, pseudogene 0.413263
VWDE von Willebrand factor D and EGF domains 0.389336
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.367808
PTPRR protein tyrosine phosphatase, receptor type, R 0.362047
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 0.353527
LY86-AS1 LY86 antisense RNA 1 0.340128
PAQR4 progestin and adipoQ receptor family member IV 0.33862
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.33862
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.33862
FRMD3 FERM domain containing 3 0.326988
NEB nebulin 0.289333
COL4A1 collagen, type IV, alpha 1 0.278777
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.272049
AADACL4 arylacetamide deacetylase-like 4 0.26831
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.262604
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.258075
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.257958
IL6 interleukin 6 0.248636
TOB1 transducer of ERBB2, 1 0.24847
PLA2R1 phospholipase A2 receptor 1, 180kDa 0.244227
BBX bobby sox homolog (Drosophila) 0.219245
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.217638
STXBP6 syntaxin binding protein 6 (amisyn) 0.216972
AKAP12 A kinase (PRKA) anchor protein 12 0.206545
IL12A interleukin 12A 0.203695
NRG2 neuregulin 2 0.198186
NT5DC4 5'-nucleotidase domain containing 4 0.197646
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.190112
PCNXL2 pecanex-like 2 (Drosophila) 0.188028
FYN FYN proto-oncogene, Src family tyrosine kinase 0.178881
GRID1 glutamate receptor, ionotropic, delta 1 0.178414
CSMD3 CUB and Sushi multiple domains 3 0.166618
DPY19L2 dpy-19-like 2 (C. elegans) 0.165054
PLB1 phospholipase B1 0.164559
PLA2G2E phospholipase A2, group IIE 0.160018
RPL23P9 ribosomal protein L23 pseudogene 9 0.159433
PACRG PARK2 co-regulated 0.158678
AOC1 amine oxidase, copper containing 1 0.15603
ALPI alkaline phosphatase, intestinal 0.155303
PITRM1 pitrilysin metallopeptidase 1 0.154637
IMPG1 interphotoreceptor matrix proteoglycan 1 0.154361
RNF13 ring finger protein 13 0.153703
MED20 mediator complex subunit 20 0.150293
KIAA0895 KIAA0895 0.147875
MTSS1 metastasis suppressor 1 0.146902
EVA1A eva-1 homolog A (C. elegans) 0.132229
GPC6 glypican 6 0.130034
GABPB1 GA binding protein transcription factor, beta subunit 1 0.123922
FAM13A family with sequence similarity 13, member A 0.122747
PAMR1 peptidase domain containing associated with muscle regeneration 1 0.119219
KIF5B kinesin family member 5B 0.118302
CNTNAP2 contactin associated protein-like 2 0.117869
SCFD2 sec1 family domain containing 2 0.117459
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.110752
KIF13B kinesin family member 13B 0.105326
GMDS GDP-mannose 4,6-dehydratase 0.104386
TCEA2 transcription elongation factor A (SII), 2 0.099633
CCND3 cyclin D3 0.09576
ZNF521 zinc finger protein 521 0.094696
ACOT13 acyl-CoA thioesterase 13 0.092596
MYO7B myosin VIIB 0.09017
VAV3 vav 3 guanine nucleotide exchange factor 0.082649
OR51I2 olfactory receptor, family 51, subfamily I, member 2 0.079473
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 0.078454
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.074915
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.07467
TMEM108 transmembrane protein 108 0.07389
PNPLA1 patatin-like phospholipase domain containing 1 0.073383
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.073154
OPCML opioid binding protein/cell adhesion molecule-like 0.069638
JAKMIP1 janus kinase and microtubule interacting protein 1 0.065513
LRP1B low density lipoprotein receptor-related protein 1B 0.064173
JAM3 junctional adhesion molecule 3 0.064138
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.061922
SIRPA signal-regulatory protein alpha 0.061705
PCDH7 protocadherin 7 0.06168
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.060858
SYN2 synapsin II 0.060619
NPTN neuroplastin 0.060111
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.058794
SIK3 SIK family kinase 3 0.057769