TTNPB-451 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the TTNPB-451 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF1 AF4/FMR2 family, member 1
AK2 adenylate kinase 2
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARFIP1 ADP-ribosylation factor interacting protein 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASCL1 achaete-scute family bHLH transcription factor 1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL7B B-cell CLL/lymphoma 7B
BCO1 beta-carotene oxygenase 1
BCR breakpoint cluster region
BMP7 bone morphogenetic protein 7
C6ORF47 chromosome 6 open reading frame 47
C7ORF26 chromosome 7 open reading frame 26
CBX6 chromobox homolog 6
CD209 CD209 molecule
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CD5 CD5 molecule
CDK17 cyclin-dependent kinase 17
CHMP5 charged multivesicular body protein 5
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CNOT2 CCR4-NOT transcription complex, subunit 2
CNTN1 contactin 1
CPOX coproporphyrinogen oxidase
CROT carnitine O-octanoyltransferase
DCP1A decapping mRNA 1A
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLG3 discs, large homolog 3 (Drosophila)
DST dystonin
EGFR epidermal growth factor receptor
EMC9 ER membrane protein complex subunit 9
EPS8L3 EPS8-like 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM162A family with sequence similarity 162, member A
FAM222B family with sequence similarity 222, member B
FAM89B family with sequence similarity 89, member B
FBXO38 F-box protein 38
FGD6 FYVE, RhoGEF and PH domain containing 6
FKBP8 FK506 binding protein 8, 38kDa
FOXA2 forkhead box A2
GADD45B growth arrest and DNA-damage-inducible, beta
GBAP1 glucosidase, beta, acid pseudogene 1
GDF10 growth differentiation factor 10
GLRA2 glycine receptor, alpha 2
GRK5 G protein-coupled receptor kinase 5
HP1BP3 heterochromatin protein 1, binding protein 3
HSPB11 heat shock protein family B (small), member 11
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IL11 interleukin 11
IL4R interleukin 4 receptor
ITGB5 integrin, beta 5
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL9 kelch-like family member 9
LAMP2 lysosomal-associated membrane protein 2
LPPR2 lipid phosphate phosphatase-related protein type 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCHR1 melanin-concentrating hormone receptor 1
MYCBP MYC binding protein
MYL10 myosin, light chain 10, regulatory
NIPAL3 NIPA-like domain containing 3
OGFRL1 opioid growth factor receptor-like 1
OVGP1 oviductal glycoprotein 1, 120kDa
PDCD2 programmed cell death 2
PISD phosphatidylserine decarboxylase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
RBKS ribokinase
RIPPLY3 ripply transcriptional repressor 3
RNF141 ring finger protein 141
RPS2 ribosomal protein S2
RUNDC3A RUN domain containing 3A
RUNX1 runt-related transcription factor 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNX1 sorting nexin 1
SNX19 sorting nexin 19
SPTBN1 spectrin, beta, non-erythrocytic 1
TADA3 transcriptional adaptor 3
THOC1 THO complex 1
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM176A transmembrane protein 176A
TMEM187 transmembrane protein 187
TNK1 tyrosine kinase, non-receptor, 1
TOB2 transducer of ERBB2, 2
TRD T cell receptor delta locus
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSKU tsukushi, small leucine rich proteoglycan
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WIZ widely interspaced zinc finger motifs
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZBTB40 zinc finger and BTB domain containing 40
ZC3H12A zinc finger CCCH-type containing 12A
ZNF536 zinc finger protein 536

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADAP2 ArfGAP with dual PH domains 2
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ATXN2 ataxin 2
AXIN1 axin 1
BCAS4 breast carcinoma amplified sequence 4
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA6 carbonic anhydrase VI
CCDC132 coiled-coil domain containing 132
CD70 CD70 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CRYBB2P1 crystallin, beta B2 pseudogene 1
CXORF56 chromosome X open reading frame 56
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCC DCC netrin 1 receptor
DGKD diacylglycerol kinase, delta 130kDa
DIO3 deiodinase, iodothyronine, type III
DLX4 distal-less homeobox 4
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNASE1L2 deoxyribonuclease I-like 2
DUSP8 dual specificity phosphatase 8
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPX eosinophil peroxidase
EVPL envoplakin
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FKBP6 FK506 binding protein 6, 36kDa
FLRT1 fibronectin leucine rich transmembrane protein 1
FOXJ1 forkhead box J1
GAB2 GRB2-associated binding protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAS8 growth arrest-specific 8
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GSTZ1 glutathione S-transferase zeta 1
GTPBP2 GTP binding protein 2
GUCA2A guanylate cyclase activator 2A (guanylin)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
IL10RA interleukin 10 receptor, alpha
KLHL25 kelch-like family member 25
LDHC lactate dehydrogenase C
LOC441601 septin 7 pseudogene
LRRK1 leucine-rich repeat kinase 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAL mal, T-cell differentiation protein
MAPKBP1 mitogen-activated protein kinase binding protein 1
MC5R melanocortin 5 receptor
MMP3 matrix metallopeptidase 3
MNT MAX network transcriptional repressor
MPPED1 metallophosphoesterase domain containing 1
MT1M metallothionein 1M
MTERF4 mitochondrial transcription termination factor 4
NDNF neuron-derived neurotrophic factor
NDRG4 NDRG family member 4
NPY neuropeptide Y
NSUN7 NOP2/Sun domain family, member 7
NTSR1 neurotensin receptor 1 (high affinity)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR4 progestin and adipoQ receptor family member IV
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHGB5 protocadherin gamma subfamily B, 5
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PENK proenkephalin
PFAS phosphoribosylformylglycinamidine synthase
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PNOC prepronociceptin
PRSS21 protease, serine, 21 (testisin)
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RGS17 regulator of G-protein signaling 17
SARAF store-operated calcium entry-associated regulatory factor
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC38A10 solute carrier family 38, member 10
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSTR4 somatostatin receptor 4
STX5 syntaxin 5
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
UNKL unkempt family zinc finger-like
VPS9D1 VPS9 domain containing 1
WT1-AS WT1 antisense RNA
ZNF267 zinc finger protein 267
ZNF665 zinc finger protein 665