TGFBR2 Kinase Domain Mutants in Cancer Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-3645790
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Genes

70 proteins participating in the TGFBR2 Kinase Domain Mutants in Cancer pathway from the Reactome Pathways dataset.

Symbol Name
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
BAMBI BMP and activin membrane-bound inhibitor
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNC cyclin C
CCNT1 cyclin T1
CCNT2 cyclin T2
CDK8 cyclin-dependent kinase 8
CDK9 cyclin-dependent kinase 9
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CGN cingulin
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
F11R F11 receptor
FKBP1A FK506 binding protein 1A, 12kDa
FURIN furin (paired basic amino acid cleaving enzyme)
HDAC1 histone deacetylase 1
JUNB jun B proto-oncogene
MEN1 multiple endocrine neoplasia I
MTMR4 myotubularin related protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARP1 poly (ADP-ribose) polymerase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCZ protein kinase C, zeta
RBL1 retinoblastoma-like 1
RHOA ras homolog family member A
RNF111 ring finger protein 111
RPS27A ribosomal protein S27a
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SP1 Sp1 transcription factor
STRAP serine/threonine kinase receptor associated protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TGIF2 TGFB-induced factor homeobox 2
TRIM33 tripartite motif containing 33
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2M ubiquitin-conjugating enzyme E2M
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP15 ubiquitin specific peptidase 15
USP9X ubiquitin specific peptidase 9, X-linked
WWTR1 WW domain containing transcription regulator 1
XPO1 exportin 1
ZFYVE9 zinc finger, FYVE domain containing 9