Stroke Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description An artery disease that is characterized by dysfunction of the blood vessels supplying the brain. (Human Disease Ontology, DOID_6713)
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Genes

289 genes associated with the trait Stroke in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.995026
BAIAP3 BAI1-associated protein 3 0.714946
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 0.618436
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.527821
PCCA propionyl CoA carboxylase, alpha polypeptide 0.502289
TTC23 tetratricopeptide repeat domain 23 0.483211
OTOG otogelin 0.441437
RBMS3 RNA binding motif, single stranded interacting protein 3 0.422369
DSCAML1 Down syndrome cell adhesion molecule like 1 0.348188
AIM1 absent in melanoma 1 0.29992
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.298509
ASTN2 astrotactin 2 0.28128
BCAS3 breast carcinoma amplified sequence 3 0.276221
VAT1L vesicle amine transport 1-like 0.270841
CREB3L2 cAMP responsive element binding protein 3-like 2 0.270379
ANO10 anoctamin 10 0.265036
SHB Src homology 2 domain containing adaptor protein B 0.253221
ESR2 estrogen receptor 2 (ER beta) 0.252046
GRM5 glutamate receptor, metabotropic 5 0.227555
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.218085
VAMP3 vesicle-associated membrane protein 3 0.203058
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.193256
ZNF804B zinc finger protein 804B 0.178954
ADCY2 adenylate cyclase 2 (brain) 0.173552
BCAN brevican 0.169926
SNX10 sorting nexin 10 0.168877
SPATA13 spermatogenesis associated 13 0.163267
PCNXL2 pecanex-like 2 (Drosophila) 0.163174
CSMD1 CUB and Sushi multiple domains 1 0.160777
CUX1 cut-like homeobox 1 0.1587
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.146837
ACAN aggrecan 0.143737
NAV2 neuron navigator 2 0.136814
ZNF555 zinc finger protein 555 0.133874
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.132852
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.12168
CAMTA1 calmodulin binding transcription activator 1 0.120815
IGSF5 immunoglobulin superfamily, member 5 0.119769
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.118763
KCNK17 potassium channel, two pore domain subfamily K, member 17 0.11805
EGLN3 egl-9 family hypoxia-inducible factor 3 0.117241
C19ORF57 chromosome 19 open reading frame 57 0.098022
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 0.097037
SPTB spectrin, beta, erythrocytic 0.095492
KCNIP4 Kv channel interacting protein 4 0.09392
MSH2 mutS homolog 2 0.086513
TGM6 transglutaminase 6 0.084686
DTNBP1 dystrobrevin binding protein 1 0.084531
TNMD tenomodulin 0.083563
SEC24A SEC24 family member A 0.080823
ARSJ arylsulfatase family, member J 0.077372
ITGB6 integrin, beta 6 0.071252
LOC285423 uncharacterized LOC285423 0.069615
TBC1D20 TBC1 domain family, member 20 0.0684
ERI3 ERI1 exoribonuclease family member 3 0.06723
KRT82 keratin 82, type II 0.064373
LY6E lymphocyte antigen 6 complex, locus E 0.0629
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 0.060505
SNRPN small nuclear ribonucleoprotein polypeptide N 0.051034
MYO16 myosin XVI 0.050888
NUDCD1 NudC domain containing 1 0.050786
CD44 CD44 molecule (Indian blood group) 0.049152
CNTNAP2 contactin associated protein-like 2 0.046743
PSD3 pleckstrin and Sec7 domain containing 3 0.046204
RNF144A ring finger protein 144A 0.044651
OR6X1 olfactory receptor, family 6, subfamily X, member 1 0.044501
TRIM8 tripartite motif containing 8 0.043113
EHF ets homologous factor 0.040834
NLRP1 NLR family, pyrin domain containing 1 0.040808
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.040085
HDC histidine decarboxylase 0.03897
CASC4 cancer susceptibility candidate 4 0.036539
NOL4 nucleolar protein 4 0.035901
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.035834
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.035455
PLA2R1 phospholipase A2 receptor 1, 180kDa 0.034419
TMEM87A transmembrane protein 87A 0.034235
SCG2 secretogranin II 0.034206
ZNF23 zinc finger protein 23 0.034178
STARD9 StAR-related lipid transfer (START) domain containing 9 0.033445
ATXN1 ataxin 1 0.032422
ADSS adenylosuccinate synthase 0.031721
NRG1 neuregulin 1 0.031693
KRT83 keratin 83, type II 0.031056
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.030577
GCLC glutamate-cysteine ligase, catalytic subunit 0.03044
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.03042
CNTN5 contactin 5 0.030185
CDAN1 codanin 1 0.02834
SLIT2 slit homolog 2 (Drosophila) 0.027752
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.027041
DAAM1 dishevelled associated activator of morphogenesis 1 0.025392
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.025112
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.024254
PID1 phosphotyrosine interaction domain containing 1 0.024139
RYR3 ryanodine receptor 3 0.023873
RNASE4 ribonuclease, RNase A family, 4 0.023712
ANG angiogenin, ribonuclease, RNase A family, 5 0.023712
AGER advanced glycosylation end product-specific receptor 0.023601
JAG2 jagged 2 0.023416
ITGA6 integrin, alpha 6 0.023282
NFIB nuclear factor I/B 0.022496
PLCE1 phospholipase C, epsilon 1 0.022418
ZNF831 zinc finger protein 831 0.022251
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.022111
AK5 adenylate kinase 5 0.021963
GATA2 GATA binding protein 2 0.021947
METTL16 methyltransferase like 16 0.021784
TEAD3 TEA domain family member 3 0.021763
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.021746
TTLL8 tubulin tyrosine ligase-like family member 8 0.021644
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 0.021469
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.021101
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.020891
FAM63B family with sequence similarity 63, member B 0.020831
TMEM105 transmembrane protein 105 0.020221
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.019852
WDR72 WD repeat domain 72 0.019756
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 0.019684
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.019588
INTS7 integrator complex subunit 7 0.019463
HPSE2 heparanase 2 (inactive) 0.019448
SPHKAP SPHK1 interactor, AKAP domain containing 0.019104
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.019057
HMCN1 hemicentin 1 0.018956
NRG2 neuregulin 2 0.018814
PCSK2 proprotein convertase subtilisin/kexin type 2 0.018654
NTM neurotrimin 0.018555
EBF1 early B-cell factor 1 0.018348
ASIC2 acid sensing (proton gated) ion channel 2 0.018096
KRT85 keratin 85, type II 0.017982
KIAA1549 KIAA1549 0.017591
ABLIM1 actin binding LIM protein 1 0.017429
SSBP3 single stranded DNA binding protein 3 0.017271
TRABD2A TraB domain containing 2A 0.01723
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.017219
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.016989
GATA6 GATA binding protein 6 0.016902
SHF Src homology 2 domain containing F 0.016508
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.016496
APCDD1 adenomatosis polyposis coli down-regulated 1 0.016304
HLF hepatic leukemia factor 0.016297
PTH2R parathyroid hormone 2 receptor 0.01628
NME7 NME/NM23 family member 7 0.016144
DOCK1 dedicator of cytokinesis 1 0.015948
APC adenomatous polyposis coli 0.015924
PDZRN4 PDZ domain containing ring finger 4 0.015872
MBD5 methyl-CpG binding domain protein 5 0.015652
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.015507
PHF21A PHD finger protein 21A 0.015437
GPR156 G protein-coupled receptor 156 0.015256
PDE4B phosphodiesterase 4B, cAMP-specific 0.015013
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 0.014538
RPA1 replication protein A1, 70kDa 0.014423
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.014138
PALLD palladin, cytoskeletal associated protein 0.013878
CTTN cortactin 0.013813
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.013806
NBEA neurobeachin 0.013754
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.013705
PDS5A PDS5 cohesin associated factor A 0.013566
FRMD4A FERM domain containing 4A 0.013532
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.013495
ADGRG3 adhesion G protein-coupled receptor G3 0.013343
BLZF1 basic leucine zipper nuclear factor 1 0.013184
SRP19 signal recognition particle 19kDa 0.013012
REEP5 receptor accessory protein 5 0.013012
LHCGR luteinizing hormone/choriogonadotropin receptor 0.012646
STON1-GTF2A1L STON1-GTF2A1L readthrough 0.012646
PHACTR2 phosphatase and actin regulator 2 0.0125
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.012466
ATP8B4 ATPase, class I, type 8B, member 4 0.012395
FCRL4 Fc receptor-like 4 0.01233
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene 0.012251
RIN2 Ras and Rab interactor 2 0.01219
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.012085
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.012078
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.012062
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.01196
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.01186
PTPRD protein tyrosine phosphatase, receptor type, D 0.011451
RUNX1 runt-related transcription factor 1 0.011423
KIRREL3 kin of IRRE like 3 (Drosophila) 0.011283
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.011268
RALYL RALY RNA binding protein-like 0.011261
SPAG16 sperm associated antigen 16 0.010997
STAB2 stabilin 2 0.01096
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.010903
CAPN3 calpain 3, (p94) 0.010695
TEX101 testis expressed 101 0.010527
ELOVL7 ELOVL fatty acid elongase 7 0.010484
TMEM241 transmembrane protein 241 0.010328
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.010322
ZC2HC1B zinc finger, C2HC-type containing 1B 0.010267
ADGRL3 adhesion G protein-coupled receptor L3 0.010138
ANXA13 annexin A13 0.009866
FMO10P flavin containing monooxygenase 10, pseudogene 0.009742
STEAP1B STEAP family member 1B 0.009644
CRAMP1L Crm, cramped-like (Drosophila) 0.009511
ANKRD6 ankyrin repeat domain 6 0.009366
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.009185
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.008909
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.008755
PANK3 pantothenate kinase 3 0.008666
TAF9BP2 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa pseudogene 2 0.008658
DCDC2 doublecortin domain containing 2 0.008542
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.008456
TBC1D16 TBC1 domain family, member 16 0.008368
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.008273
ERN1 endoplasmic reticulum to nucleus signaling 1 0.008267
SOBP sine oculis binding protein homolog (Drosophila) 0.008173
FHIT fragile histidine triad 0.008058
PRKG1 protein kinase, cGMP-dependent, type I 0.007958
CADPS2 Ca++-dependent secretion activator 2 0.00787
CABLES1 Cdk5 and Abl enzyme substrate 1 0.007845
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.00784
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.007659
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.007634
CA10 carbonic anhydrase X 0.007613
HHLA2 HERV-H LTR-associating 2 0.007588
TESPA1 thymocyte expressed, positive selection associated 1 0.007548
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.007447
FAM71F1 family with sequence similarity 71, member F1 0.007368
ACAT1 acetyl-CoA acetyltransferase 1 0.007283
TENM4 teneurin transmembrane protein 4 0.007237
SDC2 syndecan 2 0.007141
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.007066
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.00693
FAM155A family with sequence similarity 155, member A 0.006796
DLG2 discs, large homolog 2 (Drosophila) 0.006695
RAP1GAP2 RAP1 GTPase activating protein 2 0.006613
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.006487
LHFPL3 lipoma HMGIC fusion partner-like 3 0.006481
SP4 Sp4 transcription factor 0.006327
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.006262
USP49 ubiquitin specific peptidase 49 0.006186
ZDHHC13 zinc finger, DHHC-type containing 13 0.00614
RBBP5 retinoblastoma binding protein 5 0.006073
SAMD12 sterile alpha motif domain containing 12 0.006033
UBASH3B ubiquitin associated and SH3 domain containing B 0.005957
BMP8A bone morphogenetic protein 8a 0.005944
DOCK2 dedicator of cytokinesis 2 0.005876
FAM196B family with sequence similarity 196, member B 0.005876
EXOSC3 exosome component 3 0.005874
CNTNAP5 contactin associated protein-like 5 0.005819
LTBP1 latent transforming growth factor beta binding protein 1 0.00581
TMEM245 transmembrane protein 245 0.005788
FRMPD1 FERM and PDZ domain containing 1 0.005667
SLC2A3P1 solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 0.005658
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.005588
FMN2 formin 2 0.005585
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.005575
CHN2 chimerin 2 0.005559
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.00555
CENPF centromere protein F, 350/400kDa 0.005389
ACSL1 acyl-CoA synthetase long-chain family member 1 0.005343
KIF26B kinesin family member 26B 0.005304
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.005292
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.005245
PEPD peptidase D 0.005149
SNX29 sorting nexin 29 0.005062
GPC5 glypican 5 0.005057
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.005036
ADD1 adducin 1 (alpha) 0.004949
FGD4 FYVE, RhoGEF and PH domain containing 4 0.004896
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.004878
NOM1 nucleolar protein with MIF4G domain 1 0.004816
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.004775
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.004698
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.004601
GLRA1 glycine receptor, alpha 1 0.004599
THSD7B thrombospondin, type I, domain containing 7B 0.004544
GRIK4 glutamate receptor, ionotropic, kainate 4 0.00453
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.004405
JAKMIP3 Janus kinase and microtubule interacting protein 3 0.004385
VIT vitrin 0.004356
ATP10A ATPase, class V, type 10A 0.00428
PROX1 prospero homeobox 1 0.004178
BAG3 BCL2-associated athanogene 3 0.004166
TEK TEK tyrosine kinase, endothelial 0.004146
EPHB1 EPH receptor B1 0.004118
DCLK1 doublecortin-like kinase 1 0.004096
C4ORF51 chromosome 4 open reading frame 51 0.004013
BIVM basic, immunoglobulin-like variable motif containing 0.003973
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1 0.003973
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.003879
LDB2 LIM domain binding 2 0.003873
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.003805
DNAH12 dynein, axonemal, heavy chain 12 0.003788