Reactive Oxygen Species Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. (Chemical Entities of Biological Interest Ontology, CHEBI_26523)
External Link http://ctdbase.org/detail.go?type=chem&acc=D017382
Similar Terms
Downloads & Tools

Genes

212 genes/proteins interacting with the chemical Reactive Oxygen Species from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACO2 aconitase 2, mitochondrial
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AGRN agrin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
AR androgen receptor
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP13A2 ATPase type 13A2
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
B2M beta-2-microglobulin
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BECN1 beclin 1, autophagy related
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD28 CD28 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
COL6A1 collagen, type VI, alpha 1
COX2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT3 DNA-damage-inducible transcript 3
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2A eukaryotic translation initiation factor 2A, 65kDa
ELANE elastase, neutrophil expressed
EPO erythropoietin
ESR2 estrogen receptor 2 (ER beta)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
GAS5 growth arrest-specific 5 (non-protein coding)
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFAP glial fibrillary acidic protein
GLUL glutamate-ammonia ligase
GPX1 glutathione peroxidase 1
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSBP1 heat shock factor binding protein 1
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL5 interleukin 5
IL6 interleukin 6
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KHK ketohexokinase (fructokinase)
LDHA lactate dehydrogenase A
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LHB luteinizing hormone beta polypeptide
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
MGST1 microsomal glutathione S-transferase 1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MT-ATP6 ATP synthase F0 subunit 6
MT2A metallothionein 2A
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NCF1 neutrophil cytosolic factor 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NGB neuroglobin
NGF nerve growth factor (beta polypeptide)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
ODC1 ornithine decarboxylase 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDX1 pancreatic and duodenal homeobox 1
PINK1 PTEN induced putative kinase 1
PKM pyruvate kinase, muscle
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PML promyelocytic leukemia
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDX6 peroxiredoxin 6
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKG1 protein kinase, cGMP-dependent, type I
PRNP prion protein
PRODH proline dehydrogenase (oxidase) 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTMA prothymosin, alpha
PTRF polymerase I and transcript release factor
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RNF7 ring finger protein 7
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100B S100 calcium binding protein B
SDC2 syndecan 2
SELK selenoprotein K
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC30A10 solute carrier family 30, member 10
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK17A serine/threonine kinase 17a
TGFB1 transforming growth factor, beta 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRAP1 TNF receptor-associated protein 1
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TXN thioredoxin
TXNIP thioredoxin interacting protein
TYR tyrosinase
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UROD uroporphyrinogen decarboxylase
XBP1 X-box binding protein 1
XDH xanthine dehydrogenase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF143 zinc finger protein 143