Pulmonary Embolism Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot. (Human Disease Ontology, DOID_9477)
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Genes

51 genes associated with the Pulmonary Embolism phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
APOA4 apolipoprotein A-IV
APOE apolipoprotein E
CALU calumenin
CD40 CD40 molecule, TNF receptor superfamily member 5
CRP C-reactive protein, pentraxin-related
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F11 coagulation factor XI
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
GDF15 growth differentiation factor 15
GGCX gamma-glutamyl carboxylase
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IL6 interleukin 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLKB1 kallikrein B, plasma (Fletcher factor) 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS7 regulator of G-protein signaling 7
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD1 SERTA domain containing 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
VKORC1 vitamin K epoxide reductase complex, subunit 1
ZP1 zona pellucida glycoprotein 1 (sperm receptor)