Psoriasis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales). (Human Phenotype Ontology, HP_0003765)
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Genes

238 genes associated with the Psoriasis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ADAM33 ADAM metallopeptidase domain 33
AFF3 AF4/FMR2 family, member 3
ANXA6 annexin A6
APOE apolipoprotein E
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BANK1 B-cell scaffold protein with ankyrin repeats 1
BSG basigin (Ok blood group)
C6ORF10 chromosome 6 open reading frame 10
CADM2 cell adhesion molecule 2
CADM3 cell adhesion molecule 3
CADM4 cell adhesion molecule 4
CARD14 caspase recruitment domain family, member 14
CARD8 caspase recruitment domain family, member 8
CARM1 coactivator-associated arginine methyltransferase 1
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CCR4 chemokine (C-C motif) receptor 4
CD14 CD14 molecule
CD226 CD226 molecule
CD300LF CD300 molecule-like family member f
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDSN corneodesmosin
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
COG6 component of oligomeric golgi complex 6
CRP C-reactive protein, pentraxin-related
CSMD1 CUB and Sushi multiple domains 1
CSNK1D casein kinase 1, delta
CSTA cystatin A (stefin A)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
EDN1 endothelin 1
ELMO1 engulfment and cell motility 1
ELOVL1 ELOVL fatty acid elongase 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FBXL19 F-box and leucine-rich repeat protein 19
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FLG filaggrin
FOXP3 forkhead box P3
FPGS folylpolyglutamate synthase
FRA1H fragile site, 5-azacytidine type, common, fra(1)(q42)
FUT2 fucosyltransferase 2 (secretor status included)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJB2 gap junction protein, beta 2, 26kDa
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAX1 HCLS1 associated protein X-1
HCG9 HLA complex group 9 (non-protein coding)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFIH1 interferon induced with helicase C domain 1
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IFNLR1 interferon, lambda receptor 1
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL15 interleukin 15
IL17F interleukin 17F
IL17RD interleukin 17 receptor D
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL20RA interleukin 20 receptor, alpha
IL20RB interleukin 20 receptor beta
IL21 interleukin 21
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL24 interleukin 24
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL36RN interleukin 36 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
ITLN1 intelectin 1 (galactofuranose binding)
JAK2 Janus kinase 2
JAM2 junctional adhesion molecule 2
KIF5A kinesin family member 5A
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DL5B killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DP1 killer cell immunoglobulin-like receptor, three domains, pseudogene 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KLRC2 killer cell lectin-like receptor subfamily C, member 2
LCE3B late cornified envelope 3B
LCE3C late cornified envelope 3C
LCE3D late cornified envelope 3D
LEP leptin
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LINC01185 long intergenic non-protein coding RNA 1185
LNPEP leucyl/cystinyl aminopeptidase
LRRC32 leucine rich repeat containing 32
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGST2 microsomal glutathione S-transferase 2
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP2 matrix metallopeptidase 2
MOK MOK protein kinase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NCOA5 nuclear receptor coactivator 5
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NOTCH4 notch 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PON1 paraoxonase 1
POU5F1 POU class 5 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRDX5 peroxiredoxin 5
PRKCQ protein kinase C, theta
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSORS10 psoriasis susceptibility 10
PSORS1C1 psoriasis susceptibility 1 candidate 1
PSORS4 psoriasis susceptibility 4
PSORS5 psoriasis susceptibility 5
PSORS6 psoriasis susceptibility 6
PSORS9 psoriasis susceptibility 9
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTTG1 pituitary tumor-transforming 1
RAD50 RAD50 homolog (S. cerevisiae)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFC1 replication factor C (activator 1) 1, 145kDa
RNF114 ring finger protein 114
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPTOR regulatory associated protein of MTOR, complex 1
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SLC12A8 solute carrier family 12, member 8
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
SUMO4 small ubiquitin-like modifier 4
TAGAP T-cell activation RhoGTPase activating protein
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF3IP2 TRAF3 interacting protein 2
TSC1 tuberous sclerosis 1
TYK2 tyrosine kinase 2
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
YDJC YdjC homolog (bacterial)
ZC3H12C zinc finger CCCH-type containing 12C
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF148 zinc finger protein 148
ZNF750 zinc finger protein 750
ZNF816 zinc finger protein 816