Prestwick-860-5679 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-860-5679 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACTN2 actinin, alpha 2
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ARG1 arginase 1
ATXN8OS ATXN8 opposite strand (non-protein coding)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BMP2 bone morphogenetic protein 2
C17ORF59 chromosome 17 open reading frame 59
C4BPA complement component 4 binding protein, alpha
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CLDN15 claudin 15
CLEC1A C-type lectin domain family 1, member A
COL10A1 collagen, type X, alpha 1
CSHL1 chorionic somatomammotropin hormone-like 1
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR4 chemokine (C-X-C motif) receptor 4
EFNB3 ephrin-B3
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF18 fibroblast growth factor 18
FGF6 fibroblast growth factor 6
FOXN2 forkhead box N2
GADD45G growth arrest and DNA-damage-inducible, gamma
GAS7 growth arrest-specific 7
GAST gastrin
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GLT8D2 glycosyltransferase 8 domain containing 2
GPR157 G protein-coupled receptor 157
GPR4 G protein-coupled receptor 4
GRM1 glutamate receptor, metabotropic 1
GSK3A glycogen synthase kinase 3 alpha
HHAT hedgehog acyltransferase
HIF3A hypoxia inducible factor 3, alpha subunit
HIST1H1T histone cluster 1, H1t
HIST1H3A histone cluster 1, H3a
HIST1H3J histone cluster 1, H3j
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HNF1B HNF1 homeobox B
HOXD9 homeobox D9
HP haptoglobin
ICOSLG inducible T-cell co-stimulator ligand
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1B interleukin 1, beta
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KLK7 kallikrein-related peptidase 7
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LEF1 lymphoid enhancer-binding factor 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MALL mal, T-cell differentiation protein-like
MED25 mediator complex subunit 25
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NECAB2 N-terminal EF-hand calcium binding protein 2
NPY4R neuropeptide Y receptor Y4
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRIP3 nuclear receptor interacting protein 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCM2 oncomodulin 2
OR1F1 olfactory receptor, family 1, subfamily F, member 1
OR7A10 olfactory receptor, family 7, subfamily A, member 10
ORM1 orosomucoid 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PAX2 paired box 2
PAX3 paired box 3
PCDHGA8 protocadherin gamma subfamily A, 8
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG10 paternally expressed 10
PNLIPRP1 pancreatic lipase-related protein 1
POU5F1B POU class 5 homeobox 1B
PRB3 proline-rich protein BstNI subfamily 3
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPL35A ribosomal protein L35a
SAFB scaffold attachment factor B
SAPCD1 suppressor APC domain containing 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH2D3C SH2 domain containing 3C
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC39A9 solute carrier family 39, member 9
SLC43A3 solute carrier family 43, member 3
SMAD6 SMAD family member 6
SMR3A submaxillary gland androgen regulated protein 3A
SNTA1 syntrophin, alpha 1
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
TCP10 t-complex 10
TNC tenascin C
TPP1 tripeptidyl peptidase I
TPSG1 tryptase gamma 1
TRIM22 tripartite motif containing 22
UBXN1 UBX domain protein 1
UPK3A uroplakin 3A
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZNF419 zinc finger protein 419
ZNF518A zinc finger protein 518A
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBC3 BCL2 binding component 3
BMP15 bone morphogenetic protein 15
CASD1 CAS1 domain containing 1
CCDC186 coiled-coil domain containing 186
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD302 CD302 molecule
CHKB choline kinase beta
CHMP6 charged multivesicular body protein 6
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CRELD1 cysteine-rich with EGF-like domains 1
CTC1 CTS telomere maintenance complex component 1
DGAT1 diacylglycerol O-acyltransferase 1
EFCAB2 EF-hand calcium binding domain 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPS8L2 EPS8-like 2
ERCC4 excision repair cross-complementation group 4
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL2 F-box and leucine-rich repeat protein 2
FBXO5 F-box protein 5
FLRT3 fibronectin leucine rich transmembrane protein 3
FURIN furin (paired basic amino acid cleaving enzyme)
GUSBP3 glucuronidase, beta pseudogene 3
GYS1 glycogen synthase 1 (muscle)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H2BJ histone cluster 1, H2bj
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KREMEN2 kringle containing transmembrane protein 2
LRRC37A3 leucine rich repeat containing 37, member A3
LTBP2 latent transforming growth factor beta binding protein 2
LYRM9 LYR motif containing 9
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP7D1 MAP7 domain containing 1
MATK megakaryocyte-associated tyrosine kinase
MDM4 MDM4, p53 regulator
MKNK2 MAP kinase interacting serine/threonine kinase 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OLFML2A olfactomedin-like 2A
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G15 phospholipase A2, group XV
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POM121 POM121 transmembrane nucleoporin
PRPH peripherin
PRSS16 protease, serine, 16 (thymus)
PYCRL pyrroline-5-carboxylate reductase-like
RAB33B RAB33B, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RGS19 regulator of G-protein signaling 19
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCAI suppressor of cancer cell invasion
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC46A3 solute carrier family 46, member 3
SLMO1 slowmo homolog 1 (Drosophila)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STX5 syntaxin 5
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMEM2 transmembrane protein 2
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRABD TraB domain containing
TRAIP TRAF interacting protein
TRAPPC6A trafficking protein particle complex 6A
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
VWA1 von Willebrand factor A domain containing 1
WDR19 WD repeat domain 19
WDR76 WD repeat domain 76
WLS wntless Wnt ligand secretion mediator
ZBTB6 zinc finger and BTB domain containing 6
ZNF10 zinc finger protein 10
ZNF286A zinc finger protein 286A
ZNF571 zinc finger protein 571
ZNF606 zinc finger protein 606
ZNF652 zinc finger protein 652
ZNF804A zinc finger protein 804A