Prestwick-674-3716 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-674-3716 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ACRV1 acrosomal vesicle protein 1
ADGRG3 adhesion G protein-coupled receptor G3
ADM2 adrenomedullin 2
AIM2 absent in melanoma 2
AKAP13 A kinase (PRKA) anchor protein 13
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
ARC activity-regulated cytoskeleton-associated protein
ARTN artemin
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP9B ATPase, class II, type 9B
AVPR1B arginine vasopressin receptor 1B
BBC3 BCL2 binding component 3
BCAS1 breast carcinoma amplified sequence 1
BMP1 bone morphogenetic protein 1
BMP10 bone morphogenetic protein 10
CA12 carbonic anhydrase XII
CD300C CD300c molecule
CHI3L2 chitinase 3-like 2
CLTCL1 clathrin, heavy chain-like 1
CNGB3 cyclic nucleotide gated channel beta 3
CNTD2 cyclin N-terminal domain containing 2
CST4 cystatin S
CTNS cystinosin, lysosomal cystine transporter
DAPK3 death-associated protein kinase 3
DGKQ diacylglycerol kinase, theta 110kDa
DMC1 DNA meiotic recombinase 1
DMXL2 Dmx-like 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ENG endoglin
ESR1 estrogen receptor 1
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM212B family with sequence similarity 212, member B
FANCA Fanconi anemia, complementation group A
FBXO21 F-box protein 21
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP10 FK506 binding protein 10, 65 kDa
FYB FYN binding protein
GDF5 growth differentiation factor 5
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HDAC6 histone deacetylase 6
HESX1 HESX homeobox 1
HHAT hedgehog acyltransferase
HIST1H3I histone cluster 1, H3i
HOXB3 homeobox B3
HRH3 histamine receptor H3
IFT140 intraflagellar transport 140
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
LEFTY1 left-right determination factor 1
LIPE lipase, hormone-sensitive
LTBP4 latent transforming growth factor beta binding protein 4
MATN1 matrilin 1, cartilage matrix protein
MED25 mediator complex subunit 25
MEF2D myocyte enhancer factor 2D
METTL7A methyltransferase like 7A
MIER2 mesoderm induction early response 1, family member 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MT3 metallothionein 3
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NPTX1 neuronal pentraxin I
OXCT2 3-oxoacid CoA transferase 2
PDGFA platelet-derived growth factor alpha polypeptide
PEX26 peroxisomal biogenesis factor 26
PLXND1 plexin D1
PML promyelocytic leukemia
POMT2 protein-O-mannosyltransferase 2
POU2F2 POU class 2 homeobox 2
POU3F4 POU class 3 homeobox 4
PPARA peroxisome proliferator-activated receptor alpha
RAB40AL RAB40A, member RAS oncogene family-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RIMS3 regulating synaptic membrane exocytosis 3
RNF208 ring finger protein 208
SCN11A sodium channel, voltage gated, type XI alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SHOX2 short stature homeobox 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SULT4A1 sulfotransferase family 4A, member 1
SYT5 synaptotagmin V
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAOK2 TAO kinase 2
TECTA tectorin alpha
TET3 tet methylcytosine dioxygenase 3
TMX4 thioredoxin-related transmembrane protein 4
TNS4 tensin 4
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WIPI2 WD repeat domain, phosphoinositide interacting 2
WNT3 wingless-type MMTV integration site family, member 3
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AFF4 AF4/FMR2 family, member 4
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AK5 adenylate kinase 5
ALPP alkaline phosphatase, placental
AMT aminomethyltransferase
APH1B APH1B gamma secretase subunit
BDKRB1 bradykinin receptor B1
C16ORF59 chromosome 16 open reading frame 59
C22ORF29 chromosome 22 open reading frame 29
CADPS2 Ca++-dependent secretion activator 2
CAMKMT calmodulin-lysine N-methyltransferase
CBX8 chromobox homolog 8
CD79B CD79b molecule, immunoglobulin-associated beta
CD82 CD82 molecule
CDH19 cadherin 19, type 2
CHRDL1 chordin-like 1
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCA1 chloride channel accessory 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYB5R2 cytochrome b5 reductase 2
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DOK5 docking protein 5
ERF Ets2 repressor factor
EXO5 exonuclease 5
FAM118A family with sequence similarity 118, member A
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH2L G patch domain containing 2-like
GPR3 G protein-coupled receptor 3
GPR85 G protein-coupled receptor 85
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMB major histocompatibility complex, class II, DM beta
HOXA6 homeobox A6
HOXB2 homeobox B2
IFI44L interferon-induced protein 44-like
IL2 interleukin 2
JAK2 Janus kinase 2
KIAA0513 KIAA0513
KLF3 Kruppel-like factor 3 (basic)
LMBR1L limb development membrane protein 1-like
LMO7 LIM domain 7
LMTK2 lemur tyrosine kinase 2
LOC100127972 uncharacterized LOC100127972
LOC100287590 uncharacterized LOC100287590
MARK1 MAP/microtubule affinity-regulating kinase 1
MED9 mediator complex subunit 9
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
NPFFR1 neuropeptide FF receptor 1
OLFML2B olfactomedin-like 2B
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSMR oncostatin M receptor
PAQR6 progestin and adipoQ receptor family member VI
PCDHA9 protocadherin alpha 9
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMCH pro-melanin-concentrating hormone
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PRF1 perforin 1 (pore forming protein)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRS protein tyrosine phosphatase, receptor type, S
RNF122 ring finger protein 122
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAMD9 sterile alpha motif domain containing 9
SCD5 stearoyl-CoA desaturase 5
SETD1A SET domain containing 1A
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35F6 solute carrier family 35, member F6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SLN sarcolipin
SMO smoothened, frizzled class receptor
SPANXC SPANX family, member C
SUGCT succinyl-CoA:glutarate-CoA transferase
TEX15 testis expressed 15
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM180 transmembrane protein 180
TMEM19 transmembrane protein 19
TMEM209 transmembrane protein 209
TRAC T cell receptor alpha constant
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D4 TSC22 domain family, member 4
TUBA4B tubulin, alpha 4b
VGF VGF nerve growth factor inducible
ZFHX2 zinc finger homeobox 2
ZFHX3 zinc finger homeobox 3
ZNF286A zinc finger protein 286A
ZNF415 zinc finger protein 415
ZNF480 zinc finger protein 480
ZNF516 zinc finger protein 516
ZNF573 zinc finger protein 573
ZNF702P zinc finger protein 702, pseudogene
ZNF749 zinc finger protein 749