Prestwick-559-1728 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the Prestwick-559-1728 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGGF1 angiogenic factor with G patch and FHA domains 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
AQP2 aquaporin 2 (collecting duct)
ARHGAP32 Rho GTPase activating protein 32
ATXN2 ataxin 2
BMP7 bone morphogenetic protein 7
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CALML3 calmodulin-like 3
CCDC176 coiled-coil domain containing 176
CCS copper chaperone for superoxide dismutase
CD70 CD70 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDCP1 CUB domain containing protein 1
CELA3A chymotrypsin-like elastase family, member 3A
CHPF2 chondroitin polymerizing factor 2
CIITA class II, major histocompatibility complex, transactivator
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNOT4 CCR4-NOT transcription complex, subunit 4
CRAT carnitine O-acetyltransferase
CRYAB crystallin, alpha B
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEAF1 DEAF1 transcription factor
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DENND6B DENN/MADD domain containing 6B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFCAB14 EF-hand calcium binding domain 14
EHD1 EH-domain containing 1
FBLN1 fibulin 1
FSCN3 fascin actin-bundling protein 3, testicular
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNAS GNAS complex locus
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSDMD gasdermin D
GYPB glycophorin B (MNS blood group)
HDAC5 histone deacetylase 5
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HK2 hexokinase 2
HNF1A HNF1 homeobox A
HOMER1 homer scaffolding protein 1
HSF1 heat shock transcription factor 1
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCTD13 potassium channel tetramerization domain containing 13
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1109 KIAA1109
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MB myoglobin
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
METTL13 methyltransferase like 13
NOL12 nucleolar protein 12
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUCB1 nucleobindin 1
OGFRL1 opioid growth factor receptor-like 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALM paralemmin
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLIN2 perilipin 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PSG6 pregnancy specific beta-1-glycoprotein 6
RAB11B RAB11B, member RAS oncogene family
RECQL5 RecQ protein-like 5
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOT2 ras homolog family member T2
RNF123 ring finger protein 123
SCARB2 scavenger receptor class B, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC31B SEC31 homolog B (S. cerevisiae)
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC15 sialic acid binding Ig-like lectin 15
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNTA1 syntrophin, alpha 1
SPANXC SPANX family, member C
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
STK25 serine/threonine kinase 25
TEAD4 TEA domain family member 4
THBS3 thrombospondin 3
TK2 thymidine kinase 2, mitochondrial
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMOD1 tropomodulin 1
TMSB4Y thymosin beta 4, Y-linked
TNNT1 troponin T type 1 (skeletal, slow)
TPCN1 two pore segment channel 1
TPSAB1 tryptase alpha/beta 1
TRAF1 TNF receptor-associated factor 1
TRAPPC12 trafficking protein particle complex 12
TSFM Ts translation elongation factor, mitochondrial
VILL villin-like
ZNF236 zinc finger protein 236
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACVR1 activin A receptor, type I
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALPK1 alpha-kinase 1
ARMC1 armadillo repeat containing 1
ARMC7 armadillo repeat containing 7
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AVEN apoptosis, caspase activation inhibitor
BRD9 bromodomain containing 9
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
C19ORF24 chromosome 19 open reading frame 24
CAPN1 calpain 1, (mu/I) large subunit
CARD9 caspase recruitment domain family, member 9
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBR1 carbonyl reductase 1
CD151 CD151 molecule (Raph blood group)
CEP55 centrosomal protein 55kDa
CFAP74 cilia and flagella associated protein 74
CLDND1 claudin domain containing 1
CMTR1 cap methyltransferase 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
CORO7 coronin 7
CRIP1 cysteine-rich protein 1 (intestinal)
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTDNEP1 CTD nuclear envelope phosphatase 1
CTNNBL1 catenin, beta like 1
DDT D-dopachrome tautomerase
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMC2 ER membrane protein complex subunit 2
EXOC5 exocyst complex component 5
EXOSC9 exosome component 9
FAM188A family with sequence similarity 188, member A
FBXL4 F-box and leucine-rich repeat protein 4
FBXW4 F-box and WD repeat domain containing 4
FPGS folylpolyglutamate synthase
FUBP3 far upstream element (FUSE) binding protein 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GPS1 G protein pathway suppressor 1
GSTA4 glutathione S-transferase alpha 4
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BF histone cluster 1, H2bf
HIST3H2A histone cluster 3, H2a
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IL18 interleukin 18
KCTD20 potassium channel tetramerization domain containing 20
KIFC1 kinesin family member C1
LIMD2 LIM domain containing 2
LMAN2L lectin, mannose-binding 2-like
MAD2L1BP MAD2L1 binding protein
MED17 mediator complex subunit 17
MFSD12 major facilitator superfamily domain containing 12
MORC3 MORC family CW-type zinc finger 3
MPV17 MpV17 mitochondrial inner membrane protein
MRGBP MRG/MORF4L binding protein
MYNN myoneurin
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUP93 nucleoporin 93kDa
NUPL1 nucleoporin like 1
PAK1IP1 PAK1 interacting protein 1
PARG poly (ADP-ribose) glycohydrolase
PCDHGB5 protocadherin gamma subfamily B, 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
POGLUT1 protein O-glucosyltransferase 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PRPF39 pre-mRNA processing factor 39
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
RAB8B RAB8B, member RAS oncogene family
RIN1 Ras and Rab interactor 1
RUVBL1 RuvB-like AAA ATPase 1
SAC3D1 SAC3 domain containing 1
SEC61B Sec61 beta subunit
SLC22A14 solute carrier family 22, member 14
SLC39A1 solute carrier family 39 (zinc transporter), member 1
STIP1 stress-induced phosphoprotein 1
STYXL1 serine/threonine/tyrosine interacting-like 1
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TBL3 transducin (beta)-like 3
TCTN2 tectonic family member 2
TGM5 transglutaminase 5
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM14A transmembrane protein 14A
TMEM30A transmembrane protein 30A
TMX2 thioredoxin-related transmembrane protein 2
TRAPPC2L trafficking protein particle complex 2-like
TRIM9 tripartite motif containing 9
TSPYL1 TSPY-like 1
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
USP8 ubiquitin specific peptidase 8
WDR41 WD repeat domain 41
WDR76 WD repeat domain 76
ZNF304 zinc finger protein 304
ZNF426 zinc finger protein 426