Prestwick-1103-7317 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the Prestwick-1103-7317 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
AMBRA1 autophagy/beclin-1 regulator 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATF6B activating transcription factor 6 beta
ATP9A ATPase, class II, type 9A
BIRC3 baculoviral IAP repeat containing 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD3D CD3d molecule, delta (CD3-TCR complex)
CDADC1 cytidine and dCMP deaminase domain containing 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHM choroideremia (Rab escort protein 1)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
COL1A1 collagen, type I, alpha 1
COL7A1 collagen, type VII, alpha 1
DRP2 dystrophin related protein 2
FAM174B family with sequence similarity 174, member B
FAS Fas cell surface death receptor
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPSM3 G-protein signaling modulator 3
GRM8 glutamate receptor, metabotropic 8
GTF2I general transcription factor IIi
HAMP hepcidin antimicrobial peptide
HAUS5 HAUS augmin-like complex, subunit 5
HOXD10 homeobox D10
IFIH1 interferon induced with helicase C domain 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INADL InaD-like (Drosophila)
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGB5 integrin, beta 5
KCTD13 potassium channel tetramerization domain containing 13
KLF12 Kruppel-like factor 12
KRAS Kirsten rat sarcoma viral oncogene homolog
KYNU kynureninase
LDB1 LIM domain binding 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LMO7 LIM domain 7
LOC100287590 uncharacterized LOC100287590
MAP7 microtubule-associated protein 7
MAPK14 mitogen-activated protein kinase 14
MARS methionyl-tRNA synthetase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MED25 mediator complex subunit 25
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTRF1L mitochondrial translational release factor 1-like
MYO1F myosin IF
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NINJ1 ninjurin 1
NMT2 N-myristoyltransferase 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OSBP2 oxysterol binding protein 2
PEX5 peroxisomal biogenesis factor 5
PEX7 peroxisomal biogenesis factor 7
PHF3 PHD finger protein 3
PKP3 plakophilin 3
PRF1 perforin 1 (pore forming protein)
PRSS8 protease, serine, 8
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RANBP1 RAN binding protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARG retinoic acid receptor, gamma
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RPL7 ribosomal protein L7
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SARM1 sterile alpha and TIR motif containing 1
SETD8 SET domain containing (lysine methyltransferase) 8
SIX3 SIX homeobox 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP100 SP100 nuclear antigen
SRRT serrate, RNA effector molecule
SYNE1 spectrin repeat containing, nuclear envelope 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TK2 thymidine kinase 2, mitochondrial
TPM2 tropomyosin 2 (beta)
TRIM3 tripartite motif containing 3
TUSC3 tumor suppressor candidate 3
WDR18 WD repeat domain 18
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB7A zinc finger and BTB domain containing 7A
ZNF253 zinc finger protein 253
ZNF280D zinc finger protein 280D
ZNF85 zinc finger protein 85

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALS2CL ALS2 C-terminal like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASB7 ankyrin repeat and SOCS box containing 7
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BEX1 brain expressed, X-linked 1
BOLA1 bolA family member 1
BTF3P12 basic transcription factor 3 pseudogene 12
C5ORF45 chromosome 5 open reading frame 45
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCNJL cyclin J-like
CCP110 centriolar coiled coil protein 110kDa
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDON cell adhesion associated, oncogene regulated
CEP72 centrosomal protein 72kDa
CHMP6 charged multivesicular body protein 6
CLDN14 claudin 14
CORO1A coronin, actin binding protein, 1A
CORT cortistatin
CST4 cystatin S
CTSF cathepsin F
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DLK1 delta-like 1 homolog (Drosophila)
DNAL4 dynein, axonemal, light chain 4
EAF2 ELL associated factor 2
EDAR ectodysplasin A receptor
EPN3 epsin 3
F3 coagulation factor III (thromboplastin, tissue factor)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGD6 FYVE, RhoGEF and PH domain containing 6
FHOD1 formin homology 2 domain containing 1
FUZ fuzzy planar cell polarity protein
GAREM GRB2 associated, regulator of MAPK1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH3 G patch domain containing 3
GPR3 G protein-coupled receptor 3
GSTCD glutathione S-transferase, C-terminal domain containing
H1F0 H1 histone family, member 0
HIRA histone cell cycle regulator
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPB8 heat shock 22kDa protein 8
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL15RA interleukin 15 receptor, alpha
IQCG IQ motif containing G
JAK2 Janus kinase 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIFC3 kinesin family member C3
KPTN kaptin (actin binding protein)
LPAR2 lysophosphatidic acid receptor 2
MAGEF1 melanoma antigen family F1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MYH15 myosin, heavy chain 15
NARFL nuclear prelamin A recognition factor-like
NCS1 neuronal calcium sensor 1
NECAB3 N-terminal EF-hand calcium binding protein 3
PAIP2B poly(A) binding protein interacting protein 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR14L proline rich 14-like
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPP25 ribonuclease P/MRP 25kDa subunit
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RWDD2A RWD domain containing 2A
SCD5 stearoyl-CoA desaturase 5
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERTAD3 SERTA domain containing 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAR steroidogenic acute regulatory protein
STARD3 StAR-related lipid transfer (START) domain containing 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAGLN transgelin
TENM1 teneurin transmembrane protein 1
TMEM132A transmembrane protein 132A
TMEM183A transmembrane protein 183A
TMEM242 transmembrane protein 242
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
USP27X ubiquitin specific peptidase 27, X-linked
WDR37 WD repeat domain 37
XPA xeroderma pigmentosum, complementation group A
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB39 zinc finger and BTB domain containing 39
ZNF197 zinc finger protein 197
ZNF552 zinc finger protein 552