Prestwick-1080-4532 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-1080-4532 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACRV1 acrosomal vesicle protein 1
ADTRP androgen-dependent TFPI-regulating protein
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
C17ORF53 chromosome 17 open reading frame 53
C21ORF2 chromosome 21 open reading frame 2
C2ORF27A chromosome 2 open reading frame 27A
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCDC170 coiled-coil domain containing 170
CCDC71 coiled-coil domain containing 71
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP162 centrosomal protein 162kDa
CHI3L2 chitinase 3-like 2
CLDN1 claudin 1
CORO7 coronin 7
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYTH4 cytohesin 4
DMP1 dentin matrix acidic phosphoprotein 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
ELSPBP1 epididymal sperm binding protein 1
FASTKD2 FAST kinase domains 2
FBXL18 F-box and leucine-rich repeat protein 18
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF5 fibroblast growth factor 5
FLT1 fms-related tyrosine kinase 1
FRS3 fibroblast growth factor receptor substrate 3
GMPR guanosine monophosphate reductase
GPR6 G protein-coupled receptor 6
GSK3A glycogen synthase kinase 3 alpha
HIST1H3I histone cluster 1, H3i
HNF4A hepatocyte nuclear factor 4, alpha
HPCAL4 hippocalcin like 4
IFNA14 interferon, alpha 14
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGKC immunoglobulin kappa constant
IL9R interleukin 9 receptor
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCK IQ motif containing K
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KERA keratocan
KIAA1467 KIAA1467
KIF5C kinesin family member 5C
KRT32 keratin 32, type I
LDB3 LIM domain binding 3
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MEF2D myocyte enhancer factor 2D
MRPL41 mitochondrial ribosomal protein L41
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NPFF neuropeptide FF-amide peptide precursor
PDCD2 programmed cell death 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PLCH1 phospholipase C, eta 1
PLK4 polo-like kinase 4
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121L2 POM121 transmembrane nucleoporin-like 2
POMT2 protein-O-mannosyltransferase 2
PRB4 proline-rich protein BstNI subfamily 4
PRO2964 uncharacterized protein PRO2964
PRUNE2 prune homolog 2 (Drosophila)
RCE1 Ras converting CAAX endopeptidase 1
RGS9 regulator of G-protein signaling 9
RHEB Ras homolog enriched in brain
RNF43 ring finger protein 43
RRAGD Ras-related GTP binding D
SARM1 sterile alpha and TIR motif containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC19A1 solute carrier family 19 (folate transporter), member 1
SNN stannin
STRN striatin, calmodulin binding protein
STS steroid sulfatase (microsomal), isozyme S
TAS2R1 taste receptor, type 2, member 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TLN2 talin 2
TM2D1 TM2 domain containing 1
TM4SF1 transmembrane 4 L six family member 1
TNIK TRAF2 and NCK interacting kinase
TRIM29 tripartite motif containing 29
TROVE2 TROVE domain family, member 2
TTC38 tetratricopeptide repeat domain 38
TUBA4B tubulin, alpha 4b
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR78 WD repeat domain 78
ZIC3 Zic family member 3
ZNF268 zinc finger protein 268
ZNF492 zinc finger protein 492
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADCY6 adenylate cyclase 6
AFAP1 actin filament associated protein 1
AHDC1 AT hook, DNA binding motif, containing 1
ANP32A-IT1 ANP32A intronic transcript 1
BCORL1 BCL6 corepressor-like 1
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C1ORF115 chromosome 1 open reading frame 115
C1QTNF1 C1q and tumor necrosis factor related protein 1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH7 cadherin 7, type 2
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CORO1A coronin, actin binding protein, 1A
CRELD1 cysteine-rich with EGF-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNAL4 dynein, axonemal, light chain 4
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EGR2 early growth response 2
EN2 engrailed homeobox 2
ERMP1 endoplasmic reticulum metallopeptidase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EVL Enah/Vasp-like
FAM186A family with sequence similarity 186, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
GPR39 G protein-coupled receptor 39
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC5 histone deacetylase 5
HELZ helicase with zinc finger
HIST1H2BO histone cluster 1, H2bo
HYAL3 hyaluronoglucosaminidase 3
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITPKA inositol-trisphosphate 3-kinase A
KLF3 Kruppel-like factor 3 (basic)
KRT6A keratin 6A, type II
LAMB2 laminin, beta 2 (laminin S)
LINC00341 long intergenic non-protein coding RNA 341
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MFSD12 major facilitator superfamily domain containing 12
MRPL28 mitochondrial ribosomal protein L28
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXD3 MAX dimerization protein 3
MYO1D myosin ID
NBEAL2 neurobeachin-like 2
NDRG4 NDRG family member 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NXPH4 neurexophilin 4
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PAQR6 progestin and adipoQ receptor family member VI
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PELP1 proline, glutamate and leucine rich protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLM polymerase (DNA directed), mu
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRB3 proline-rich protein BstNI subfamily 3
PRSS53 protease, serine, 53
RAD54L2 RAD54-like 2 (S. cerevisiae)
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERGEF secretion regulating guanine nucleotide exchange factor
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D2A SH2 domain containing 2A
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
ST5 suppression of tumorigenicity 5
TAGLN transgelin
TBC1D12 TBC1 domain family, member 12
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBXAS1 thromboxane A synthase 1 (platelet)
TEP1 telomerase-associated protein 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP19 ubiquitin specific peptidase 19
USP20 ubiquitin specific peptidase 20
ZNF276 zinc finger protein 276
ZNF442 zinc finger protein 442
ZNF510 zinc finger protein 510
ZNF768 zinc finger protein 768