Posterior Leukoencephalopathy Syndrome Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D054038
Similar Terms
Downloads & Tools

Genes

235 genes/proteins associated with the disease Posterior Leukoencephalopathy Syndrome from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.90125
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.88622
BCL2 B-cell CLL/lymphoma 2 1.87008
JUN jun proto-oncogene 1.83272
TP53 tumor protein p53 1.83042
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.74099
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.72988
BAX BCL2-associated X protein 1.72675
SOD2 superoxide dismutase 2, mitochondrial 1.62758
PARP1 poly (ADP-ribose) polymerase 1 1.62379
CP ceruloplasmin (ferroxidase) 1.61828
BCL2L1 BCL2-like 1 1.60151
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.58065
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.56263
FAS Fas cell surface death receptor 1.55822
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.55231
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.55035
IL6 interleukin 6 1.54159
DDIT3 DNA-damage-inducible transcript 3 1.53675
CAT catalase 1.52963
TNF tumor necrosis factor 1.50043
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.4889
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.48068
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.47556
CXCL8 chemokine (C-X-C motif) ligand 8 1.46488
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.46093
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.443
TRIM2 tripartite motif containing 2 1.43864
MAPK1 mitogen-activated protein kinase 1 1.43727
CTSL cathepsin L 1.43428
MCL1 myeloid cell leukemia 1 1.43266
BMP4 bone morphogenetic protein 4 1.43266
HMOX1 heme oxygenase 1 1.42129
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.41559
POR P450 (cytochrome) oxidoreductase 1.41174
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.41119
S100P S100 calcium binding protein P 1.39813
BIRC2 baculoviral IAP repeat containing 2 1.39394
RRM2 ribonucleotide reductase M2 1.38946
FN1 fibronectin 1 1.38669
MAPK8 mitogen-activated protein kinase 8 1.38641
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.37189
ERBB2 erb-b2 receptor tyrosine kinase 2 1.36562
PRC1 protein regulator of cytokinesis 1 1.36104
GSTP1 glutathione S-transferase pi 1 1.35242
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.34343
GADD45A growth arrest and DNA-damage-inducible, alpha 1.33966
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.33791
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.33731
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.33346
TYMS thymidylate synthetase 1.33257
MAPK3 mitogen-activated protein kinase 3 1.33169
BIRC3 baculoviral IAP repeat containing 3 1.3231
CYCS cytochrome c, somatic 1.31357
UNG uracil-DNA glycosylase 1.31059
NGF nerve growth factor (beta polypeptide) 1.31059
TGFB1 transforming growth factor, beta 1 1.30758
CTGF connective tissue growth factor 1.30604
MMP1 matrix metallopeptidase 1 1.30604
S100A4 S100 calcium binding protein A4 1.30451
H2AFX H2A histone family, member X 1.30056
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.29843
VIM vimentin 1.29287
CD274 CD274 molecule 1.29225
NRP1 neuropilin 1 1.29103
FASLG Fas ligand (TNF superfamily, member 6) 1.29072
NOS2 nitric oxide synthase 2, inducible 1.29072
IGF1 insulin-like growth factor 1 (somatomedin C) 1.28395
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.28364
VEGFA vascular endothelial growth factor A 1.2821
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.28058
FLT1 fms-related tyrosine kinase 1 1.27845
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.2772
IGFBP5 insulin-like growth factor binding protein 5 1.26638
SRGN serglycin 1.2596
PRL prolactin 1.25369
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.25183
IFNG interferon, gamma 1.24935
CDK2 cyclin-dependent kinase 2 1.2456
EPO erythropoietin 1.2456
THBS1 thrombospondin 1 1.24433
ATF3 activating transcription factor 3 1.24181
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.23962
CFLAR CASP8 and FADD-like apoptosis regulator 1.23233
FOS FBJ murine osteosarcoma viral oncogene homolog 1.23074
CCL2 chemokine (C-C motif) ligand 2 1.22501
CDK1 cyclin-dependent kinase 1 1.22469
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.22371
BRCA1 breast cancer 1, early onset 1.2208
PSAP prosaposin 1.21984
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.21759
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.21468
GSK3B glycogen synthase kinase 3 beta 1.21402
F3 coagulation factor III (thromboplastin, tissue factor) 1.20978
COL6A3 collagen, type VI, alpha 3 1.20622
MGMT O-6-methylguanine-DNA methyltransferase 1.20295
BTG2 BTG family, member 2 1.20295
IL15RA interleukin 15 receptor, alpha 1.20295
BIRC5 baculoviral IAP repeat containing 5 1.20196
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.199
VCAN versican 1.19574
CD44 CD44 molecule (Indian blood group) 1.19542
MMP3 matrix metallopeptidase 3 1.19146
OSBPL10 oxysterol binding protein-like 10 1.19047
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.19047
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.18849
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.18652
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.18359
TYMP thymidine phosphorylase 1.18359
CCNB1 cyclin B1 1.18226
COL1A1 collagen, type I, alpha 1 1.18093
VCAM1 vascular cell adhesion molecule 1 1.17926
RGS4 regulator of G-protein signaling 4 1.17893
F2 coagulation factor II (thrombin) 1.17662
RB1 retinoblastoma 1 1.17596
MYL9 myosin, light chain 9, regulatory 1.17464
TUBB3 tubulin, beta 3 class III 1.17431
MAP2 microtubule-associated protein 2 1.16967
IGFBP3 insulin-like growth factor binding protein 3 1.16866
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.16733
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.1617
CD68 CD68 molecule 1.16104
BUB3 BUB3 mitotic checkpoint protein 1.16104
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.15899
EGR1 early growth response 1 1.15763
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.15695
COL4A1 collagen, type IV, alpha 1 1.15492
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.15089
HSPA8 heat shock 70kDa protein 8 1.14954
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.14919
MARCKS myristoylated alanine-rich protein kinase C substrate 1.1485
CSF1 colony stimulating factor 1 (macrophage) 1.14816
CCND1 cyclin D1 1.14404
PLAT plasminogen activator, tissue 1.14302
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.14302
TOP2A topoisomerase (DNA) II alpha 170kDa 1.14302
BAD BCL2-associated agonist of cell death 1.142
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.1403
TLR4 toll-like receptor 4 1.13997
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 1.13621
CLU clusterin 1.13586
NPPA natriuretic peptide A 1.13586
CDKN3 cyclin-dependent kinase inhibitor 3 1.13415
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 1.11911
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.11809
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.11775
DPYD dihydropyrimidine dehydrogenase 1.11431
TJP3 tight junction protein 3 1.1136
CXCL10 chemokine (C-X-C motif) ligand 10 1.10942
CCNE1 cyclin E1 1.10562
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.10388
TAGLN transgelin 1.10353
BID BH3 interacting domain death agonist 1.10282
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.10211
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 1.1014
MYO6 myosin VI 1.1014
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.09716
DHFR dihydrofolate reductase 1.09541
CYLD cylindromatosis (turban tumor syndrome) 1.09436
S100A9 S100 calcium binding protein A9 1.09083
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.09083
G6PC glucose-6-phosphatase, catalytic subunit 1.09047
PKP2 plakophilin 2 1.09011
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.08619
MAPK14 mitogen-activated protein kinase 14 1.08513
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 1.08266
FANCG Fanconi anemia, complementation group G 1.07983
HDAC4 histone deacetylase 4 1.07983
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.07947
FNBP1 formin binding protein 1 1.07911
MUCL1 mucin-like 1 1.07589
CA12 carbonic anhydrase XII 1.07589
TGFBR3 transforming growth factor, beta receptor III 1.07553
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.07411
GPX2 glutathione peroxidase 2 1.07199
BBC3 BCL2 binding component 3 1.07057
ICAM1 intercellular adhesion molecule 1 1.06917
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.06771
CDA cytidine deaminase 1.06625
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.06442
NPPB natriuretic peptide B 1.0637
CCNG1 cyclin G1 1.06333
GADD45B growth arrest and DNA-damage-inducible, beta 1.06333
COL4A2 collagen, type IV, alpha 2 1.06225
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 1.05972
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.059
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.059
NFE2L2 nuclear factor, erythroid 2-like 2 1.05864
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.05793
CYR61 cysteine-rich, angiogenic inducer, 61 1.05721
SPON1 spondin 1, extracellular matrix protein 1.05685
PDCD1LG2 programmed cell death 1 ligand 2 1.0561
CCND3 cyclin D3 1.05498
ANXA1 annexin A1 1.05461
CCNB2 cyclin B2 1.05461
TIMP1 TIMP metallopeptidase inhibitor 1 1.05163
GFRA1 GDNF family receptor alpha 1 1.04941
IL1RN interleukin 1 receptor antagonist 1.04904
EDNRB endothelin receptor type B 1.04904
INSIG1 insulin induced gene 1 1.04904
TGFB2 transforming growth factor, beta 2 1.04757
HSPA1B heat shock 70kDa protein 1B 1.04757
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.04684
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.04501
CD24 CD24 molecule 1.04427
KIF15 kinesin family member 15 1.04389
SELE selectin E 1.04239
MELK maternal embryonic leucine zipper kinase 1.04088
AREG amphiregulin 1.04051
MTUS1 microtubule associated tumor suppressor 1 1.03752
PLK4 polo-like kinase 4 1.03752
ACKR3 atypical chemokine receptor 3 1.03752
GRB10 growth factor receptor-bound protein 10 1.03752
NQO1 NAD(P)H dehydrogenase, quinone 1 1.03678
PPARG peroxisome proliferator-activated receptor gamma 1.03641
NR2F1 nuclear receptor subfamily 2, group F, member 1 1.03567
TOB1 transducer of ERBB2, 1 1.03456
SNAI2 snail family zinc finger 2 1.03009
ATF4 activating transcription factor 4 1.02933
CALB1 calbindin 1, 28kDa 1.02933
MT1E metallothionein 1E 1.02933
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.02783
NCOA3 nuclear receptor coactivator 3 1.02634
C3 complement component 3 1.02522
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.02447
PLTP phospholipid transfer protein 1.0241
DDIT4 DNA-damage-inducible transcript 4 1.02151
GEM GTP binding protein overexpressed in skeletal muscle 1.0204
IL23A interleukin 23, alpha subunit p19 1.01928
GAMT guanidinoacetate N-methyltransferase 1.01814
GSTM1 glutathione S-transferase mu 1 1.01549
COL1A2 collagen, type I, alpha 2 1.01474
NCL nucleolin 1.01324
CXCL12 chemokine (C-X-C motif) ligand 12 1.01286
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 1.01062