Parkinsonian Disorders Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D020734
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Genes

311 genes/proteins associated with the disease Parkinsonian Disorders from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
GSR glutathione reductase 2.88009
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.88009
PINK1 PTEN induced putative kinase 1 2.88009
PARK2 parkin RBR E3 ubiquitin protein ligase 2.88009
PRKCD protein kinase C, delta 2.88009
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.88009
LRRK2 leucine-rich repeat kinase 2 2.88009
MAPT microtubule-associated protein tau 2.88009
DCTN1 dynactin 1 2.88009
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.88009
NGF nerve growth factor (beta polypeptide) 2.88009
GDNF glial cell derived neurotrophic factor 2.88009
PRL prolactin 2.88009
NOS2 nitric oxide synthase 2, inducible 2.88009
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.88009
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.88009
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.88009
DRD2 dopamine receptor D2 2.88009
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 2.88009
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.88009
POLG polymerase (DNA directed), gamma 2.88009
PDYN prodynorphin 2.88009
PARP1 poly (ADP-ribose) polymerase 1 2.88009
TH tyrosine hydroxylase 2.88009
DRD1 dopamine receptor D1 2.42495
FOS FBJ murine osteosarcoma viral oncogene homolog 2.4216
CAT catalase 2.36941
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.29962
BCL2 B-cell CLL/lymphoma 2 2.27065
DRD3 dopamine receptor D3 2.26205
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.22114
CREB1 cAMP responsive element binding protein 1 2.20283
BAX BCL2-associated X protein 2.19026
TNF tumor necrosis factor 2.14469
SOD1 superoxide dismutase 1, soluble 2.09939
BDNF brain-derived neurotrophic factor 2.09024
MAPK1 mitogen-activated protein kinase 1 2.08104
MAPK3 mitogen-activated protein kinase 3 2.05845
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.05608
MAPK8 mitogen-activated protein kinase 8 2.01295
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.98424
GFAP glial fibrillary acidic protein 1.98224
MAOB monoamine oxidase B 1.96269
PENK proenkephalin 1.96269
COMT catechol-O-methyltransferase 1.96239
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.90076
EGR1 early growth response 1 1.88638
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.88142
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.88092
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.87344
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.8689
GSK3B glycogen synthase kinase 3 beta 1.85975
JUN jun proto-oncogene 1.85608
CCND1 cyclin D1 1.84959
SOD2 superoxide dismutase 2, mitochondrial 1.84305
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.83841
HMOX1 heme oxygenase 1 1.83183
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.80491
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.78778
NFE2L2 nuclear factor, erythroid 2-like 2 1.78264
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.77859
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.75915
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.73455
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.73353
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.7226
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.71789
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.70782
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.70574
INS insulin 1.68868
ADORA2A adenosine A2a receptor 1.67029
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.67029
DRD4 dopamine receptor D4 1.66857
MAPK9 mitogen-activated protein kinase 9 1.66533
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.66425
LEP leptin 1.66145
APP amyloid beta (A4) precursor protein 1.65314
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.64551
IFNG interferon, gamma 1.63653
NOS1 nitric oxide synthase 1 (neuronal) 1.6325
NUPR1 nuclear protein, transcriptional regulator, 1 1.61483
XBP1 X-box binding protein 1 1.60804
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.58398
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.57571
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.5721
TP53 tumor protein p53 1.56607
TXN thioredoxin 1.56263
NQO1 NAD(P)H dehydrogenase, quinone 1 1.56141
PPARG peroxisome proliferator-activated receptor gamma 1.56044
CRH corticotropin releasing hormone 1.56019
SREBF1 sterol regulatory element binding transcription factor 1 1.55946
ADIPOQ adiponectin, C1Q and collagen domain containing 1.54912
IL1B interleukin 1, beta 1.54718
NPY neuropeptide Y 1.54354
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.54111
IGF1 insulin-like growth factor 1 (somatomedin C) 1.53941
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.53603
CCL2 chemokine (C-C motif) ligand 2 1.53135
DDIT3 DNA-damage-inducible transcript 3 1.52938
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.51004
PCNA proliferating cell nuclear antigen 1.50751
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.50725
GSTP1 glutathione S-transferase pi 1 1.49558
IL6 interleukin 6 1.49278
UBB ubiquitin B 1.49071
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.48967
IL1A interleukin 1, alpha 1.48864
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.48531
TGFB1 transforming growth factor, beta 1 1.48479
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.47634
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.47193
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.47089
ELK1 ELK1, member of ETS oncogene family 1.45989
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.45247
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.43455
NOS3 nitric oxide synthase 3 (endothelial cell) 1.43401
ACHE acetylcholinesterase (Yt blood group) 1.42211
ATF4 activating transcription factor 4 1.41775
ERN1 endoplasmic reticulum to nucleus signaling 1 1.41721
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.41586
FAS Fas cell surface death receptor 1.41586
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.40568
RGS2 regulator of G-protein signaling 2 1.40316
HSF1 heat shock transcription factor 1 1.39086
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.3903
CYBB cytochrome b-245, beta polypeptide 1.38527
FNDC4 fibronectin type III domain containing 4 1.36933
VEGFA vascular endothelial growth factor A 1.36905
POMC proopiomelanocortin 1.36876
FASN fatty acid synthase 1.36247
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.36104
GSTM1 glutathione S-transferase mu 1 1.35934
LDLR low density lipoprotein receptor 1.35184
GCLC glutamate-cysteine ligase, catalytic subunit 1.34576
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.34576
TAGLN transgelin 1.34285
NTS neurotensin 1.3414
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.3414
ENO1 enolase 1, (alpha) 1.33081
JUNB jun B proto-oncogene 1.32369
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.32369
CD36 CD36 molecule (thrombospondin receptor) 1.32192
C10ORF10 chromosome 10 open reading frame 10 1.32132
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.31927
GADD45A growth arrest and DNA-damage-inducible, alpha 1.31867
INHBE inhibin, beta E 1.31297
MAPK14 mitogen-activated protein kinase 14 1.31
CHGA chromogranin A 1.29966
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.29936
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.29812
GLUL glutamate-ammonia ligase 1.29657
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.29133
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.29133
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.29011
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.2895
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.28889
PARK7 parkinson protein 7 1.28518
GPX1 glutathione peroxidase 1 1.28425
BCL2L1 BCL2-like 1 1.28364
ADCY5 adenylate cyclase 5 1.28119
RTN4 reticulon 4 1.28088
SREBF2 sterol regulatory element binding transcription factor 2 1.28088
DUSP1 dual specificity phosphatase 1 1.28088
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.27626
VGF VGF nerve growth factor inducible 1.27533
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.27409
FABP1 fatty acid binding protein 1, liver 1.27378
CDK4 cyclin-dependent kinase 4 1.2707
TAC1 tachykinin, precursor 1 1.26763
LPL lipoprotein lipase 1.26763
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.26638
EN2 engrailed homeobox 2 1.26483
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.26298
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.26144
SIRT1 sirtuin 1 1.2596
LHB luteinizing hormone beta polypeptide 1.25929
ICAM1 intercellular adhesion molecule 1 1.25713
EN1 engrailed homeobox 1 1.2509
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.24997
HPN hepsin 1.2475
MAOA monoamine oxidase A 1.24307
PGK1 phosphoglycerate kinase 1 1.24087
GCLM glutamate-cysteine ligase, modifier subunit 1.23074
EIF2A eukaryotic translation initiation factor 2A, 65kDa 1.23011
CASP12 caspase 12 (gene/pseudogene) 1.22948
TXNRD1 thioredoxin reductase 1 1.22916
RGS8 regulator of G-protein signaling 8 1.22758
GAL galanin/GMAP prepropeptide 1.22632
MPO myeloperoxidase 1.22404
TRIB3 tribbles pseudokinase 3 1.22274
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.21663
MMP9 matrix metallopeptidase 9 1.21599
ADORA1 adenosine A1 receptor 1.21567
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.21271
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.21271
TJP1 tight junction protein 1 1.21271
ALB albumin 1.21141
G6PC glucose-6-phosphatase, catalytic subunit 1.21011
ATF6 activating transcription factor 6 1.20848
NPPA natriuretic peptide A 1.20784
JUND jun D proto-oncogene 1.20493
DDIT4 DNA-damage-inducible transcript 4 1.20328
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.20097
TFRC transferrin receptor 1.20064
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.19146
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.19047
IL10 interleukin 10 1.18948
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.18849
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.18652
ODC1 ornithine decarboxylase 1 1.18521
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.18456
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.18456
CYCS cytochrome c, somatic 1.18456
CXCL8 chemokine (C-X-C motif) ligand 8 1.18126
RET ret proto-oncogene 1.17827
ANXA2 annexin A2 1.17629
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.17497
GSTA4 glutathione S-transferase alpha 4 1.17235
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.16866
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.16633
MT1A metallothionein 1A 1.16434
TIMP1 TIMP metallopeptidase inhibitor 1 1.15763
ACACB acetyl-CoA carboxylase beta 1.15391
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.15156
HBB hemoglobin, beta 1.14713
GSTM2 glutathione S-transferase mu 2 (muscle) 1.14507
CALCA calcitonin-related polypeptide alpha 1.14507
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.14268
HSPA1B heat shock 70kDa protein 1B 1.13793
BAK1 BCL2-antagonist/killer 1 1.13586
TTLL10 tubulin tyrosine ligase-like family member 10 1.13347
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.13041
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.12973
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.1294
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.1294
HSPA8 heat shock 70kDa protein 8 1.12838
GPX4 glutathione peroxidase 4 1.12668
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.12219
ATF3 activating transcription factor 3 1.12117
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.11945
BAD BCL2-associated agonist of cell death 1.11606
G6PD glucose-6-phosphate dehydrogenase 1.11606
CCNB1 cyclin B1 1.11536
TLR4 toll-like receptor 4 1.1122
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.10942
VIM vimentin 1.10527
RB1 retinoblastoma 1 1.10424
CDK5 cyclin-dependent kinase 5 1.10388
FLCN folliculin 1.10388
HIGD1A HIG1 hypoxia inducible domain family, member 1A 1.10388
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.10282
RSPRY1 ring finger and SPRY domain containing 1 1.10246
FASLG Fas ligand (TNF superfamily, member 6) 1.10175
WEE1 WEE1 G2 checkpoint kinase 1.09998
PCDH7 protocadherin 7 1.09892
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.09716
NBN nibrin 1.09366
ARC activity-regulated cytoskeleton-associated protein 1.09297
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.0894
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1.0894
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 1.08868
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.08407
CROT carnitine O-octanoyltransferase 1.07911
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.07911
RNF183 ring finger protein 183 1.07518
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.06987
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.06952
HSPB1 heat shock 27kDa protein 1 1.06661
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.06588
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.06588
NPVF neuropeptide VF precursor 1.06297
EPO erythropoietin 1.06297
CDC42 cell division cycle 42 1.06261
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.06261
IL2 interleukin 2 1.06044
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.05828
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.0561
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.05423
EDN1 endothelin 1 1.052
ACO2 aconitase 2, mitochondrial 1.04978
FTH1 ferritin, heavy polypeptide 1 1.04831
OPA1 optic atrophy 1 (autosomal dominant) 1.04647
PRDX1 peroxiredoxin 1 1.04574
KEAP1 kelch-like ECH-associated protein 1 1.04574
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.04276
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.04051
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.03939
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa 1.03864
ANGPTL4 angiopoietin-like 4 1.03864
LYPD6 LY6/PLAUR domain containing 6 1.03827
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.03715
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.03641
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.03419
HEXA hexosaminidase A (alpha polypeptide) 1.03345
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 1.03345
GSTA3 glutathione S-transferase alpha 3 1.03308
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.03122
TSHB thyroid stimulating hormone, beta 1.02821
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 1.02746
MAP2K1 mitogen-activated protein kinase kinase 1 1.02559
KLF4 Kruppel-like factor 4 (gut) 1.02522
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.0241
DRD5 dopamine receptor D5 1.02114
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.01966
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.01776
COL1A1 collagen, type I, alpha 1 1.01625
MAG myelin associated glycoprotein 1.01474
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.01474
VCAM1 vascular cell adhesion molecule 1 1.01399
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.01324
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.01324
NCF1 neutrophil cytosolic factor 1 1.01137