PHA-00745360-4562 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PHA-00745360-4562 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
APOE apolipoprotein E
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARPIN actin-related protein 2/3 complex inhibitor
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF6B activating transcription factor 6 beta
BCCIP BRCA2 and CDKN1A interacting protein
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BEX1 brain expressed, X-linked 1
C1ORF116 chromosome 1 open reading frame 116
CA5B carbonic anhydrase VB, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CDC14A cell division cycle 14A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK12 cyclin-dependent kinase 12
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP295 centrosomal protein 295kDa
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CLTCL1 clathrin, heavy chain-like 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYTH1 cytohesin 1
DPF1 D4, zinc and double PHD fingers family 1
DST dystonin
EGFR epidermal growth factor receptor
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FAM204A family with sequence similarity 204, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXO31 F-box protein 31
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF5 fibroblast growth factor 5
FYB FYN binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GLP1R glucagon-like peptide 1 receptor
GLRA1 glycine receptor, alpha 1
GPNMB glycoprotein (transmembrane) nmb
GPR19 G protein-coupled receptor 19
GRAMD1C GRAM domain containing 1C
GREB1L growth regulation by estrogen in breast cancer-like
GSK3A glycogen synthase kinase 3 alpha
HIC2 hypermethylated in cancer 2
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
IFNA14 interferon, alpha 14
IL18R1 interleukin 18 receptor 1
IL20RA interleukin 20 receptor, alpha
ING4 inhibitor of growth family, member 4
LEPROT leptin receptor overlapping transcript
LOC100294391 uncharacterized LOC100294391
LRP4 low density lipoprotein receptor-related protein 4
LRRC40 leucine rich repeat containing 40
LY96 lymphocyte antigen 96
MUC7 mucin 7, secreted
NKTR natural killer cell triggering receptor
NLE1 notchless homolog 1 (Drosophila)
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP54 nucleoporin 54kDa
PCDHB3 protocadherin beta 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHEX phosphate regulating endopeptidase homolog, X-linked
PLCH1 phospholipase C, eta 1
POU2F2 POU class 2 homeobox 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCI protein kinase C, iota
PRPH peripherin
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB31 RAB31, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RECQL5 RecQ protein-like 5
RGS12 regulator of G-protein signaling 12
RND1 Rho family GTPase 1
RPL10L ribosomal protein L10-like
SCARB1 scavenger receptor class B, member 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH2D1A SH2 domain containing 1A
SIRT5 sirtuin 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SOD2 superoxide dismutase 2, mitochondrial
SRSF1 serine/arginine-rich splicing factor 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK24 serine/threonine kinase 24
TLN2 talin 2
TNIK TRAF2 and NCK interacting kinase
TPP1 tripeptidyl peptidase I
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTLL7 tubulin tyrosine ligase-like family member 7
UGCG UDP-glucose ceramide glucosyltransferase
WAPAL wings apart-like homolog (Drosophila)
WIZ widely interspaced zinc finger motifs
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFP64 ZFP64 zinc finger protein
ZHX3 zinc fingers and homeoboxes 3
ZNF280B zinc finger protein 280B
ZNF589 zinc finger protein 589
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADAM2 ADAM metallopeptidase domain 2
ATAT1 alpha tubulin acetyltransferase 1
BTF3P12 basic transcription factor 3 pseudogene 12
C9ORF9 chromosome 9 open reading frame 9
CAMKMT calmodulin-lysine N-methyltransferase
CCDC106 coiled-coil domain containing 106
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD101 CD101 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDKL3 cyclin-dependent kinase-like 3
CLDN11 claudin 11
CPED1 cadherin-like and PC-esterase domain containing 1
CPNE7 copine VII
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DBR1 debranching RNA lariats 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENO3 enolase 3 (beta, muscle)
FBRS fibrosin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLRT3 fibronectin leucine rich transmembrane protein 3
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDAP1 ganglioside induced differentiation associated protein 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR1 G protein-coupled receptor 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIST1H2AK histone cluster 1, H2ak
HIST1H4D histone cluster 1, H4d
HOXC4 homeobox C4
HPR haptoglobin-related protein
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFT140 intraflagellar transport 140
IL15RA interleukin 15 receptor, alpha
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD7 potassium channel tetramerization domain containing 7
KIFC3 kinesin family member C3
KLHL28 kelch-like family member 28
KRT31 keratin 31, type I
KRT86 keratin 86, type II
KRT8P12 keratin 8 pseudogene 12
LATS1 large tumor suppressor kinase 1
LAX1 lymphocyte transmembrane adaptor 1
LOC729164 hCG1732469
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAST3 microtubule associated serine/threonine kinase 3
MDFI MyoD family inhibitor
MT1M metallothionein 1M
MTA2 metastasis associated 1 family, member 2
MTMR11 myotubularin related protein 11
MXRA8 matrix-remodelling associated 8
MYO1F myosin IF
NAG18 NAG18 mRNA
NDRG4 NDRG family member 4
NT5DC3 5'-nucleotidase domain containing 3
PDE12 phosphodiesterase 12
PDE8B phosphodiesterase 8B
PGPEP1 pyroglutamyl-peptidase I
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAC8 placenta-specific 8
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRSS53 protease, serine, 53
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAPSN receptor-associated protein of the synapse
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RFPL1S RFPL1 antisense RNA 1
RGCC regulator of cell cycle
RNF122 ring finger protein 122
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SH3D21 SH3 domain containing 21
SLC12A9 solute carrier family 12, member 9
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMR3A submaxillary gland androgen regulated protein 3A
SOX12 SRY (sex determining region Y)-box 12
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAB2 stabilin 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TENM1 teneurin transmembrane protein 1
THRAP3 thyroid hormone receptor associated protein 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTLL1 tubulin tyrosine ligase-like family member 1
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR33 WD repeat domain 33
WNT10B wingless-type MMTV integration site family, member 10B
ZNF214 zinc finger protein 214
ZNF510 zinc finger protein 510
ZNF778 zinc finger protein 778