PHA-00745360-4559 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the PHA-00745360-4559 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADPRH ADP-ribosylarginine hydrolase
ANGEL2 angel homolog 2 (Drosophila)
AQP4 aquaporin 4
ARID1A AT rich interactive domain 1A (SWI-like)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
B9D2 B9 protein domain 2
BCL2 B-cell CLL/lymphoma 2
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF1 chromosome 14 open reading frame 1
C17ORF53 chromosome 17 open reading frame 53
C1ORF116 chromosome 1 open reading frame 116
C8ORF44 chromosome 8 open reading frame 44
CBX8 chromobox homolog 8
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFAP45 cilia and flagella associated protein 45
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CLCN7 chloride channel, voltage-sensitive 7
CTNS cystinosin, lysosomal cystine transporter
DCX doublecortin
EPN1 epsin 1
FGF5 fibroblast growth factor 5
FH fumarate hydratase
FKBP5 FK506 binding protein 5
FLJ21369 uncharacterized protein FLJ21369
FLT1 fms-related tyrosine kinase 1
GFER growth factor, augmenter of liver regeneration
GLE1 GLE1 RNA export mediator
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRM8 glutamate receptor, metabotropic 8
GSTA1 glutathione S-transferase alpha 1
HEMK1 HemK methyltransferase family member 1
HGFAC HGF activator
HIST1H2AJ histone cluster 1, H2aj
HOXD1 homeobox D1
ICAM1 intercellular adhesion molecule 1
IQCK IQ motif containing K
IRF4 interferon regulatory factor 4
KCNIP2 Kv channel interacting protein 2
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1109 KIAA1109
KIF17 kinesin family member 17
KLK7 kallikrein-related peptidase 7
KMT2A lysine (K)-specific methyltransferase 2A
LDAH lipid droplet associated hydrolase
LY86 lymphocyte antigen 86
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K7CL MAP3K7 C-terminal like
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MDM4 MDM4, p53 regulator
METTL7A methyltransferase like 7A
MMP11 matrix metallopeptidase 11
MRAS muscle RAS oncogene homolog
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFASC neurofascin
NPR2 natriuretic peptide receptor 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP160 nucleoporin 160kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POU2F2 POU class 2 homeobox 2
PPP1R7 protein phosphatase 1, regulatory subunit 7
PTPRH protein tyrosine phosphatase, receptor type, H
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAD51 RAD51 recombinase
RASA3 RAS p21 protein activator 3
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RPL7 ribosomal protein L7
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RUNX1 runt-related transcription factor 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIRT4 sirtuin 4
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPATA1 spermatogenesis associated 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRSF1 serine/arginine-rich splicing factor 1
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STS steroid sulfatase (microsomal), isozyme S
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAPBPL TAP binding protein-like
TCEAL2 transcription elongation factor A (SII)-like 2
TDO2 tryptophan 2,3-dioxygenase
THOC5 THO complex 5
TMOD1 tropomodulin 1
TONSL tonsoku-like, DNA repair protein
TPD52L1 tumor protein D52-like 1
TUBA4B tubulin, alpha 4b
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1
ZNF280B zinc finger protein 280B

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAT1 adenosine deaminase, tRNA-specific 1
ALS2CL ALS2 C-terminal like
AMDHD2 amidohydrolase domain containing 2
ARL14 ADP-ribosylation factor-like 14
ARMC6 armadillo repeat containing 6
BAAT bile acid CoA:amino acid N-acyltransferase
BCAS3 breast carcinoma amplified sequence 3
BTBD2 BTB (POZ) domain containing 2
C5ORF45 chromosome 5 open reading frame 45
C8ORF60 chromosome 8 open reading frame 60
CAMKMT calmodulin-lysine N-methyltransferase
CENPT centromere protein T
CES3 carboxylesterase 3
CHD3 chromodomain helicase DNA binding protein 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTNAP3B contactin associated protein-like 3B
CPNE7 copine VII
CTC1 CTS telomere maintenance complex component 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAH7 dynein, axonemal, heavy chain 7
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNM3 dynamin 3
DTX2 deltex 2, E3 ubiquitin ligase
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELP6 elongator acetyltransferase complex subunit 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETNK2 ethanolamine kinase 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FOXC1 forkhead box C1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GJA8 gap junction protein, alpha 8, 50kDa
GLDC glycine dehydrogenase (decarboxylating)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HDAC5 histone deacetylase 5
HIST1H2AM histone cluster 1, H2am
HOXA7 homeobox A7
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM5C lysine (K)-specific demethylase 5C
KLF3 Kruppel-like factor 3 (basic)
KRT15 keratin 15, type I
KRT8P12 keratin 8 pseudogene 12
LAX1 lymphocyte transmembrane adaptor 1
LINC00597 long intergenic non-protein coding RNA 597
LMNB2 lamin B2
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRK1 leucine-rich repeat kinase 1
MANBA mannosidase, beta A, lysosomal
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK3 mitogen-activated protein kinase 3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MICALL2 MICAL-like 2
MLYCD malonyl-CoA decarboxylase
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTA2 metastasis associated 1 family, member 2
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOD1 nucleotide-binding oligomerization domain containing 1
NPFFR1 neuropeptide FF receptor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALM paralemmin
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
POLL polymerase (DNA directed), lambda
PRPH peripherin
PRR15L proline rich 15-like
RAB36 RAB36, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHOBTB2 Rho-related BTB domain containing 2
RNF122 ring finger protein 122
RPAP1 RNA polymerase II associated protein 1
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SHROOM2 shroom family member 2
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SPEG SPEG complex locus
ST5 suppression of tumorigenicity 5
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TENM1 teneurin transmembrane protein 1
TFEB transcription factor EB
TRIM66 tripartite motif containing 66
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D4 TSC22 domain family, member 4
UGT8 UDP glycosyltransferase 8
USP21 ubiquitin specific peptidase 21
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZNF37BP zinc finger protein 37B, pseudogene
ZNF768 zinc finger protein 768