Osteoarthritis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An arthritis that has_material_basis_in worn out cartilage located_in joint. (Human Disease Ontology, DOID_8398)
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Genes

121 genes associated with the Osteoarthritis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABHD16A abhydrolase domain containing 16A
ACE angiotensin I converting enzyme
ADAM12 ADAM metallopeptidase domain 12
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIF1 allograft inflammatory factor 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APOM apolipoprotein M
ASPN asporin
B2M beta-2-microglobulin
BAG6 BCL2-associated athanogene 6
BMP5 bone morphogenetic protein 5
C5 complement component 5
C6ORF47 chromosome 6 open reading frame 47
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL11A1 collagen, type XI, alpha 1
COL11A2 collagen, type XI, alpha 2
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CRP C-reactive protein, pentraxin-related
CSNK1D casein kinase 1, delta
CSNK2B casein kinase 2, beta polypeptide
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DIO3 deiodinase, iodothyronine, type III
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FRA1H fragile site, 5-azacytidine type, common, fra(1)(q42)
FRZB frizzled-related protein
FTO fat mass and obesity associated
GC group-specific component (vitamin D binding protein)
GDF5 growth differentiation factor 5
GHR growth hormone receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPANK1 G patch domain and ankyrin repeats 1
GPX1 glutathione peroxidase 1
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IHH indian hedgehog
IL10 interleukin 10
IL13 interleukin 13
IL17A interleukin 17A
IL17F interleukin 17F
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
IL1RL2 interleukin 1 receptor-like 2
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KL klotho
LECT1 leukocyte cell derived chemotaxin 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LY6G5C lymphocyte antigen 6 complex, locus G5C
MATN1 matrilin 1, cartilage matrix protein
MATN3 matrilin 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MCF2L MCF.2 cell line derived transforming sequence-like
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NME8 NME/NM23 family member 8
OLIG3 oligodendrocyte transcription factor 3
PRRC2A proline-rich coiled-coil 2A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHOB ras homolog family member B
ROR2 receptor tyrosine kinase-like orphan receptor 2
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SOST sclerostin
STAT4 signal transducer and activator of transcription 4
TGFB1 transforming growth factor, beta 1
THRA thyroid hormone receptor, alpha
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP4 TIMP metallopeptidase inhibitor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRAF1 TNF receptor-associated factor 1
TXNRD2 thioredoxin reductase 2
USP33 ubiquitin specific peptidase 33
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIMP VCP-interacting membrane selenoprotein
WISP1 WNT1 inducible signaling pathway protein 1