Osteoarthritis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An arthritis that has_material_basis_in worn out cartilage located_in joint. (Human Disease Ontology, DOID_8398)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D010003
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Genes

141 genes/proteins associated with the disease Osteoarthritis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TGM2 transglutaminase 2 2.88009
CXCL6 chemokine (C-X-C motif) ligand 6 2.88009
SDCBP syndecan binding protein (syntenin) 2.88009
ASPN asporin 2.88009
AKR1C1 aldo-keto reductase family 1, member C1 2.88009
TFPI2 tissue factor pathway inhibitor 2 2.88009
MSN moesin 2.88009
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.88009
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 2.88009
SEC23A Sec23 homolog A (S. cerevisiae) 2.88009
AKR1C2 aldo-keto reductase family 1, member C2 2.88009
CXCL2 chemokine (C-X-C motif) ligand 2 2.88009
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.88009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.88009
PLS3 plastin 3 2.88009
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.88009
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.88009
ESD esterase D 2.88009
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.88009
COL2A1 collagen, type II, alpha 1 2.88009
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.88009
DPYSL2 dihydropyrimidinase-like 2 2.88009
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.88009
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.88009
PPARG peroxisome proliferator-activated receptor gamma 2.88009
CLU clusterin 2.88009
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.88009
GLS glutaminase 2.88009
MYH13 myosin, heavy chain 13, skeletal muscle 2.88009
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.88009
GSTK1 glutathione S-transferase kappa 1 2.88009
GDF5 growth differentiation factor 5 2.88009
TXNRD1 thioredoxin reductase 1 2.88009
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 2.88009
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.88009
PDCD6IP programmed cell death 6 interacting protein 2.88009
VDAC2 voltage-dependent anion channel 2 2.88009
CALCA calcitonin-related polypeptide alpha 2.88009
VIM vimentin 2.88009
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.88009
IMMT inner membrane protein, mitochondrial 2.88009
MVP major vault protein 2.88009
P3H3 prolyl 3-hydroxylase 3 2.88009
TRAP1 TNF receptor-associated protein 1 2.88009
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.88009
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.88009
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.88009
EEF2 eukaryotic translation elongation factor 2 2.88009
LTBP3 latent transforming growth factor beta binding protein 3 2.88009
ISOC2 isochorismatase domain containing 2 2.88009
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.88009
ACO1 aconitase 1, soluble 2.88009
AK4 adenylate kinase 4 2.88009
RAN RAN, member RAS oncogene family 2.88009
COL1A2 collagen, type I, alpha 2 2.88009
COL6A2 collagen, type VI, alpha 2 2.88009
ACAA2 acetyl-CoA acyltransferase 2 2.88009
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.88009
COMP cartilage oligomeric matrix protein 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
FRZB frizzled-related protein 2.88009
MATN3 matrilin 3 2.88009
CLIC1 chloride intracellular channel 1 2.88009
CLIC4 chloride intracellular channel 4 2.88009
SMAD3 SMAD family member 3 2.88009
OS4 Osteoarthritis, generalized, without dysplasia, susceptibility to 2.88009
OS6 Osteoarthritis susceptibility 6 2.88009
SCRN1 secernin 1 2.88009
POU3F3 POU class 3 homeobox 3 2.88009
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 2.88009
CTSD cathepsin D 2.88009
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.88009
OPA1 optic atrophy 1 (autosomal dominant) 2.88009
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.88009
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.88009
ENO1 enolase 1, (alpha) 2.88009
EZR ezrin 2.88009
TRIM2 tripartite motif containing 2 2.88009
EDIL3 EGF-like repeats and discoidin I-like domains 3 2.88009
FTL ferritin, light polypeptide 2.88009
ACTB actin, beta 2.88009
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.88009
PLCD1 phospholipase C, delta 1 2.88009
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.917
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.7681
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.74601
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.73838
SELL selectin L 1.65731
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.58607
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.54086
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.53061
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.52693
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.48479
ALB albumin 1.4351
IL1B interleukin 1, beta 1.42347
TNF tumor necrosis factor 1.41667
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.41313
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.39702
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.34082
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.32339
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.31506
IL6 interleukin 6 1.30543
MPO myeloperoxidase 1.26514
CHUK conserved helix-loop-helix ubiquitous kinase 1.26483
DDIT3 DNA-damage-inducible transcript 3 1.25338
GCLC glutamate-cysteine ligase, catalytic subunit 1.20622
CCND1 cyclin D1 1.20394
IL1A interleukin 1, alpha 1.19179
MMP3 matrix metallopeptidase 3 1.1908
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.18718
PPARD peroxisome proliferator-activated receptor delta 1.18059
BIRC5 baculoviral IAP repeat containing 5 1.17268
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.16866
BID BH3 interacting domain death agonist 1.1607
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.15797
CCL3 chemokine (C-C motif) ligand 3 1.15458
ICAM1 intercellular adhesion molecule 1 1.14336
PTGES prostaglandin E synthase 1.13862
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.12771
VEGFA vascular endothelial growth factor A 1.12668
HSF1 heat shock transcription factor 1 1.12391
MMP1 matrix metallopeptidase 1 1.12391
BAK1 BCL2-antagonist/killer 1 1.11707
MMP9 matrix metallopeptidase 9 1.10596
NOS2 nitric oxide synthase 2, inducible 1.09332
GSK3B glycogen synthase kinase 3 beta 1.0894
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.08797
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.08161
IL10 interleukin 10 1.06406
LTA lymphotoxin alpha 1.06044
PDGFA platelet-derived growth factor alpha polypeptide 1.06044
JUND jun D proto-oncogene 1.05573
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.05573
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.05015
NGFR nerve growth factor receptor 1.04014
FOS FBJ murine osteosarcoma viral oncogene homolog 1.03976
GCLM glutamate-cysteine ligase, modifier subunit 1.03604
MAPK14 mitogen-activated protein kinase 14 1.02373
NGF nerve growth factor (beta polypeptide) 1.01512
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.01361
CFLAR CASP8 and FADD-like apoptosis regulator 1.01174