Osteoarthritis, Knee Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

108 genes associated with the Osteoarthritis, Knee phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADAM12 ADAM metallopeptidase domain 12
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
AGER advanced glycosylation end product-specific receptor
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AR androgen receptor
ASPN asporin
BAG6 BCL2-associated athanogene 6
BCAP29 B-cell receptor-associated protein 29
BCL9 B-cell CLL/lymphoma 9
BDKRB2 bradykinin receptor B2
BMP2 bone morphogenetic protein 2
BTNL2 butyrophilin-like 2
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CD36 CD36 molecule (thrombospondin receptor)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC3B C-type lectin domain family 3, member B
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL2A1 collagen, type II, alpha 1
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CYBA cytochrome b-245, alpha polypeptide
DIO2 deiodinase, iodothyronine, type II
DIO3 deiodinase, iodothyronine, type III
DUS4L dihydrouridine synthase 4-like (S. cerevisiae)
DVL2 dishevelled segment polarity protein 2
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FRZB frizzled-related protein
FTO fat mass and obesity associated
FZD5 frizzled class receptor 5
GDF5 growth differentiation factor 5
GHRHR growth hormone releasing hormone receptor
GPR22 G protein-coupled receptor 22
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPBP phosphate binding apolipoprotein
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
KL klotho
LEP leptin
LEPR leptin receptor
LIN7C lin-7 homolog C (C. elegans)
LPAR1 lysophosphatidic acid receptor 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MCF2L MCF.2 cell line derived transforming sequence-like
MEFV Mediterranean fever
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
NCOR2 nuclear receptor corepressor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME8 NME/NM23 family member 8
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PITX1 paired-like homeodomain 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHOB ras homolog family member B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD3 SMAD family member 3
SOST sclerostin
SP7 Sp7 transcription factor
SREBF2 sterol regulatory element binding transcription factor 2
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRPV1 transient receptor potential cation channel, subfamily V, member 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT16 wingless-type MMTV integration site family, member 16