Muscle Rigidity Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity. (Human Phenotype Ontology, HP_0002063)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009127
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Genes

143 genes/proteins associated with the disease Muscle Rigidity from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
GCH1 GTP cyclohydrolase 1 2.88009
PDE8B phosphodiesterase 8B 2.88009
NPY neuropeptide Y 2.88009
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.88009
NTS neurotensin 2.88009
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.42417
DRD2 dopamine receptor D2 2.39543
FOS FBJ murine osteosarcoma viral oncogene homolog 2.37053
PRL prolactin 2.35929
BDNF brain-derived neurotrophic factor 2.3435
PENK proenkephalin 2.23462
DRD1 dopamine receptor D1 2.16121
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.12368
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.10441
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.0587
MAPK1 mitogen-activated protein kinase 1 2.02931
MAPK3 mitogen-activated protein kinase 3 2.00274
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.99625
TNF tumor necrosis factor 1.98726
TH tyrosine hydroxylase 1.97983
CRH corticotropin releasing hormone 1.96891
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.967
EGR1 early growth response 1 1.92642
TAC1 tachykinin, precursor 1 1.92156
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.90853
PDYN prodynorphin 1.89343
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.8648
POMC proopiomelanocortin 1.85292
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.85256
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.78168
DRD3 dopamine receptor D3 1.77955
NOS2 nitric oxide synthase 2, inducible 1.76946
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.76559
BCL2 B-cell CLL/lymphoma 2 1.74984
OPRM1 opioid receptor, mu 1 1.74341
CAT catalase 1.72988
BAX BCL2-associated X protein 1.71586
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.71132
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.70409
ADORA2A adenosine A2a receptor 1.7014
DRD4 dopamine receptor D4 1.69555
GFAP glial fibrillary acidic protein 1.67847
ARC activity-regulated cytoskeleton-associated protein 1.67847
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.67311
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.67289
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.66835
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.66317
JUNB jun B proto-oncogene 1.62557
IL6 interleukin 6 1.61506
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.61413
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.59334
CHRM1 cholinergic receptor, muscarinic 1 1.58771
CREB1 cAMP responsive element binding protein 1 1.58184
COMT catechol-O-methyltransferase 1.57354
AVP arginine vasopressin 1.56288
JUN jun proto-oncogene 1.55946
NGF nerve growth factor (beta polypeptide) 1.55304
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.55133
MAOB monoamine oxidase B 1.52938
CHRM5 cholinergic receptor, muscarinic 5 1.51632
REN renin 1.5012
GRM1 glutamate receptor, metabotropic 1 1.48736
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.48273
GSK3B glycogen synthase kinase 3 beta 1.47864
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.47686
CNR1 cannabinoid receptor 1 (brain) 1.47322
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.46409
FAS Fas cell surface death receptor 1.46172
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.45962
IFNG interferon, gamma 1.4351
IL1B interleukin 1, beta 1.43455
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.43347
CHRM3 cholinergic receptor, muscarinic 3 1.42562
INS insulin 1.41802
MAOA monoamine oxidase A 1.38213
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.37532
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.35877
ADRA2A adrenoceptor alpha 2A 1.35763
GRM5 glutamate receptor, metabotropic 5 1.34053
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.33761
RGS2 regulator of G-protein signaling 2 1.33346
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1.33199
IL10 interleukin 10 1.32132
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.3039
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.28395
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.25525
CHRM4 cholinergic receptor, muscarinic 4 1.254
MAP2 microtubule-associated protein 2 1.25276
GRIK5 glutamate receptor, ionotropic, kainate 5 1.25183
SOD1 superoxide dismutase 1, soluble 1.24935
EGR2 early growth response 2 1.24874
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.24401
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.23899
ADRA1A adrenoceptor alpha 1A 1.23899
GRIK2 glutamate receptor, ionotropic, kainate 2 1.23743
TP53 tumor protein p53 1.2336
GDNF glial cell derived neurotrophic factor 1.23233
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.21663
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.21141
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.21043
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.20394
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.20328
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.19999
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.19477
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.19113
HOMER1 homer scaffolding protein 1 1.19047
OPRK1 opioid receptor, kappa 1 1.19047
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.19047
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.18456
SOD2 superoxide dismutase 2, mitochondrial 1.18093
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.142
BCHE butyrylcholinesterase 1.13862
ACHE acetylcholinesterase (Yt blood group) 1.13758
CDK5 cyclin-dependent kinase 5 1.13007
CCK cholecystokinin 1.11606
LEP leptin 1.11186
PVALB parvalbumin 1.11081
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.10803
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.10388
PRKCE protein kinase C, epsilon 1.10353
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.09998
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.08975
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.08407
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.08337
RGS9 regulator of G-protein signaling 9 1.07768
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.0766
TGFB1 transforming growth factor, beta 1 1.07553
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.07482
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.06844
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 1.06625
VIP vasoactive intestinal peptide 1.05793
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.05648
CHRM2 cholinergic receptor, muscarinic 2 1.04794
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.03641
TRH thyrotropin-releasing hormone 1.03419
APP amyloid beta (A4) precursor protein 1.03345
MAPK8 mitogen-activated protein kinase 8 1.03345
VEGFA vascular endothelial growth factor A 1.03084
CCND1 cyclin D1 1.02299
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.02262
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.02003
DUSP1 dual specificity phosphatase 1 1.01212
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.01212