Multiple Organ Failure Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009102
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Genes

166 genes/proteins associated with the disease Multiple Organ Failure from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
IL10 interleukin 10 2.88009
SST somatostatin 2.88009
TNF tumor necrosis factor 2.88009
MMP9 matrix metallopeptidase 9 2.88009
ALOX5 arachidonate 5-lipoxygenase 2.88009
LBP lipopolysaccharide binding protein 2.88009
BAX BCL2-associated X protein 1.75301
BCL2 B-cell CLL/lymphoma 2 1.62268
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.59451
BCL2L1 BCL2-like 1 1.58467
CAT catalase 1.58303
CYCS cytochrome c, somatic 1.57186
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.55402
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.52865
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.50498
JUN jun proto-oncogene 1.50069
PARP1 poly (ADP-ribose) polymerase 1 1.48761
IL6 interleukin 6 1.47838
GSTP1 glutathione S-transferase pi 1 1.46935
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.45115
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.44626
FOS FBJ murine osteosarcoma viral oncogene homolog 1.44517
FAS Fas cell surface death receptor 1.44382
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.41911
ATXN1 ataxin 1 1.41884
E2F1 E2F transcription factor 1 1.41775
ATF4 activating transcription factor 4 1.41202
IL1B interleukin 1, beta 1.41091
CD44 CD44 molecule (Indian blood group) 1.40513
HMOX1 heme oxygenase 1 1.38612
GADD45A growth arrest and DNA-damage-inducible, alpha 1.36418
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.35242
IER5 immediate early response 5 1.34869
VCAM1 vascular cell adhesion molecule 1 1.34723
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.34401
TRAF2 TNF receptor-associated factor 2 1.34198
GCLC glutamate-cysteine ligase, catalytic subunit 1.32846
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.32607
DUSP1 dual specificity phosphatase 1 1.32399
EGR1 early growth response 1 1.3231
APAF1 apoptotic peptidase activating factor 1 1.31716
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.31387
MPO myeloperoxidase 1.30543
CFLAR CASP8 and FADD-like apoptosis regulator 1.30238
LPIN1 lipin 1 1.29688
BAK1 BCL2-antagonist/killer 1 1.28827
FBL fibrillarin 1.28518
MAPK14 mitogen-activated protein kinase 14 1.28303
MGMT O-6-methylguanine-DNA methyltransferase 1.2707
SOD2 superoxide dismutase 2, mitochondrial 1.26825
PRKCZ protein kinase C, zeta 1.26825
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.267
DDIT4 DNA-damage-inducible transcript 4 1.26083
ZNF200 zinc finger protein 200 1.25682
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.25338
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.25152
MAP7 microtubule-associated protein 7 1.24997
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.23106
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.2279
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.22566
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.22339
CCL2 chemokine (C-C motif) ligand 2 1.21468
CXCL8 chemokine (C-X-C motif) ligand 8 1.21011
H2AFX H2A histone family, member X 1.20558
STAT1 signal transducer and activator of transcription 1, 91kDa 1.19966
FGF2 fibroblast growth factor 2 (basic) 1.19639
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.19445
NQO1 NAD(P)H dehydrogenase, quinone 1 1.18882
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.18751
IL1A interleukin 1, alpha 1.18751
MAPK3 mitogen-activated protein kinase 3 1.17728
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.17497
TUBA4A tubulin, alpha 4a 1.16933
MAPK1 mitogen-activated protein kinase 1 1.169
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.16302
TP53 tumor protein p53 1.16269
BID BH3 interacting domain death agonist 1.16137
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 1.16001
PTK2 protein tyrosine kinase 2 1.15967
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 1.15933
EGF epidermal growth factor 1.15831
VEGFA vascular endothelial growth factor A 1.15593
CCDC51 coiled-coil domain containing 51 1.15156
CCND1 cyclin D1 1.15089
MAP2K2 mitogen-activated protein kinase kinase 2 1.15022
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.14989
TXNRD1 thioredoxin reductase 1 1.14954
NOS2 nitric oxide synthase 2, inducible 1.14919
TFPI2 tissue factor pathway inhibitor 2 1.14507
ARNTL aryl hydrocarbon receptor nuclear translocator-like 1.14473
SRXN1 sulfiredoxin 1 1.1437
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1.142
TXN2 thioredoxin 2 1.13621
BDNF brain-derived neurotrophic factor 1.13245
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.13075
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.1253
TRIM38 tripartite motif containing 38 1.12426
F3 coagulation factor III (thromboplastin, tissue factor) 1.12323
BTG2 BTG family, member 2 1.11606
CHEK1 checkpoint kinase 1 1.11606
GSK3B glycogen synthase kinase 3 beta 1.1129
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.1122
PUS3 pseudouridylate synthase 3 1.1122
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.11116
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.10977
SOD1 superoxide dismutase 1, soluble 1.10872
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 1.10562
MSH6 mutS homolog 6 1.10493
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 1.10246
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.10033
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.09857
ICAM1 intercellular adhesion molecule 1 1.09506
PRKCD protein kinase C, delta 1.09471
FYN FYN proto-oncogene, Src family tyrosine kinase 1.09047
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 1.08975
TMEM19 transmembrane protein 19 1.0894
AHCYL1 adenosylhomocysteinase-like 1 1.07875
TSPAN4 tetraspanin 4 1.07875
BIRC3 baculoviral IAP repeat containing 3 1.07589
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.07518
PLXNB2 plexin B2 1.06917
ALB albumin 1.06808
LHX2 LIM homeobox 2 1.06479
NGF nerve growth factor (beta polypeptide) 1.06261
PCNA proliferating cell nuclear antigen 1.06008
PELO pelota homolog (Drosophila) 1.06008
MATN2 matrilin 2 1.05972
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.05936
RTKN rhotekin 1.05573
TGFB1 transforming growth factor, beta 1 1.05423
GDF15 growth differentiation factor 15 1.05237
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.052
LIMCH1 LIM and calponin homology domains 1 1.05052
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.05015
CREM cAMP responsive element modulator 1.04794
POLQ polymerase (DNA directed), theta 1.04647
FOXO1 forkhead box O1 1.04574
XDH xanthine dehydrogenase 1.04465
CDC6 cell division cycle 6 1.04427
GALM galactose mutarotase (aldose 1-epimerase) 1.04276
ZNF202 zinc finger protein 202 1.04088
EDN1 endothelin 1 1.04014
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.04014
TIPIN TIMELESS interacting protein 1.03827
PFN1 profilin 1 1.03752
THRA thyroid hormone receptor, alpha 1.03419
FZD5 frizzled class receptor 5 1.03345
RHOB ras homolog family member B 1.02858
ZNF544 zinc finger protein 544 1.02783
DDIT3 DNA-damage-inducible transcript 3 1.02783
FGFR1 fibroblast growth factor receptor 1 1.02671
RRAS related RAS viral (r-ras) oncogene homolog 1.02596
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.02559
CCNE2 cyclin E2 1.02522
HMG20B high mobility group 20B 1.02485
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.02485
ATF7 activating transcription factor 7 1.02299
HSPA1A heat shock 70kDa protein 1A 1.02114
DPYSL4 dihydropyrimidinase-like 4 1.01814
HPCAL1 hippocalcin-like 1 1.01739
EMP2 epithelial membrane protein 2 1.01437
EGR2 early growth response 2 1.01437
DDR1 discoidin domain receptor tyrosine kinase 1 1.01437
CLIC1 chloride intracellular channel 1 1.01399
KLF6 Kruppel-like factor 6 1.01286
EIF3A eukaryotic translation initiation factor 3, subunit A 1.01025