Mitotic Prometaphase Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. (Gene Ontology, GO_0000236)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-68877
Similar Terms
Downloads & Tools

Genes

108 proteins participating in the Mitotic Prometaphase pathway from the Reactome Pathways dataset.

Symbol Name
AHCTF1 AT hook containing transcription factor 1
APITD1 apoptosis-inducing, TAF9-like domain 1
AURKB aurora kinase B
B9D2 B9 protein domain 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CASC5 cancer susceptibility candidate 5
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDCA5 cell division cycle associated 5
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CENPI centromere protein I
CENPK centromere protein K
CENPL centromere protein L
CENPM centromere protein M
CENPN centromere protein N
CENPO centromere protein O
CENPP centromere protein P
CENPQ centromere protein Q
CENPT centromere protein T
CENPU centromere protein U
CKAP5 cytoskeleton associated protein 5
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLIP1 CAP-GLY domain containing linker protein 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DSN1 DSN1, MIS12 kinetochore complex component
ERCC6L excision repair cross-complementation group 6-like
HDAC8 histone deacetylase 8
INCENP inner centromere protein antigens 135/155kDa
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF18A kinesin family member 18A
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KNTC1 kinetochore associated 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MIS12 MIS12 kinetochore complex component
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NSL1 NSL1, MIS12 kinetochore complex component
NUDC nudC nuclear distribution protein
NUF2 NUF2, NDC80 kinetochore complex component
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RAD21 RAD21 homolog (S. pombe)
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RCC2 regulator of chromosome condensation 2
RPS27 ribosomal protein S27
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SGOL1 shugoshin-like 1 (S. pombe)
SGOL2 shugoshin-like 2 (S. pombe)
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SPC24 SPC24, NDC80 kinetochore complex component
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
STAG1 stromal antigen 1
STAG2 stromal antigen 2
TAOK1 TAO kinase 1
WAPAL wings apart-like homolog (Drosophila)
XPO1 exportin 1
ZW10 zw10 kinetochore protein
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein