Marijuana Abuse Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A substance abuse that involves the recurring use of cannabis despite negative consequences. (Human Disease Ontology, DOID_9505)
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Genes

65 genes associated with the Marijuana Abuse phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADRA2C adrenoceptor alpha 2C
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1
ANKK1 ankyrin repeat and kinase domain containing 1
BDNF brain-derived neurotrophic factor
BPTF bromodomain PHD finger transcription factor
C17ORF58 chromosome 17 open reading frame 58
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CHRM3 cholinergic receptor, muscarinic 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
DAOA D-amino acid oxidase activator
DISC1 disrupted in schizophrenia 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DTNBP1 dystrobrevin binding protein 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
FAAH fatty acid amide hydrolase
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FKBP5 FK506 binding protein 5
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GPM6A glycoprotein M6A
GRM3 glutamate receptor, metabotropic 3
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
LRRTM1 leucine rich repeat transmembrane neuronal 1
MAPK14 mitogen-activated protein kinase 14
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NRG1 neuregulin 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PENK proenkephalin
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
POMC proopiomelanocortin
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRDM2 PR domain containing 2, with ZNF domain
PRODH proline dehydrogenase (oxidase) 1
RGS17 regulator of G-protein signaling 17
RGS2 regulator of G-protein signaling 2
RGS20 regulator of G-protein signaling 20
RGS4 regulator of G-protein signaling 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TBX1 T-box 1