Malaria Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (Human Disease Ontology, DOID_12365)
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Genes

106 genes associated with the Malaria phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACP1 acid phosphatase 1, soluble
ADA adenosine deaminase
ADCY9 adenylate cyclase 9
AIF1 allograft inflammatory factor 1
APOE apolipoprotein E
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CHIT1 chitinase 1 (chitotriosidase)
CISH cytokine inducible SH2-containing protein
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FLT1 fms-related tyrosine kinase 1
G6PD glucose-6-phosphate dehydrogenase
GNAS GNAS complex locus
GYPA glycophorin A (MNS blood group)
HBA1 hemoglobin, alpha 1
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IGH immunoglobulin heavy locus
IGKC immunoglobulin kappa constant
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4 interleukin 4
IRF1 interferon regulatory factor 1
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MBL2 mannose-binding lectin (protein C) 2, soluble
MICB MHC class I polypeptide-related sequence B
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCR3 natural cytotoxicity triggering receptor 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
PKLR pyruvate kinase, liver and RBC
PRRC2A proline-rich coiled-coil 2A
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD50 RAD50 homolog (S. cerevisiae)
RHCE Rh blood group, CcEe antigens
RTN3 reticulon 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC44A4 solute carrier family 44, member 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAS2R16 taste receptor, type 2, member 16
TGFB1 transforming growth factor, beta 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TP53 tumor protein p53
TPI1 triosephosphate isomerase 1
TRB T cell receptor beta locus
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7