MG-262-7079 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the MG-262-7079 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
ALOXE3 arachidonate lipoxygenase 3
ANKLE2 ankyrin repeat and LEM domain containing 2
ARG2 arginase 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
CARS cysteinyl-tRNA synthetase
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLK1 CDC-like kinase 1
CLU clusterin
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNB31 deafness, autosomal recessive 31
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGF epidermal growth factor
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FKBP4 FK506 binding protein 4, 59kDa
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45B growth arrest and DNA-damage-inducible, beta
GPN1 GPN-loop GTPase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL11 interleukin 11
IL17RB interleukin 17 receptor B
IL1RL1 interleukin 1 receptor-like 1
IL7R interleukin 7 receptor
JUN jun proto-oncogene
KLHL25 kelch-like family member 25
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MBOAT7 membrane bound O-acyltransferase domain containing 7
MERTK MER proto-oncogene, tyrosine kinase
MRPL18 mitochondrial ribosomal protein L18
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKRF NFKB repressing factor
OASL 2'-5'-oligoadenylate synthetase-like
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PGF placental growth factor
PLAUR plasminogen activator, urokinase receptor
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKD1 protein kinase D1
RFPL2 ret finger protein-like 2
RND1 Rho family GTPase 1
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC4 structural maintenance of chromosomes 4
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SUGP1 SURP and G patch domain containing 1
TMEM2 transmembrane protein 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM26 tripartite motif containing 26
TSPYL2 TSPY-like 2
UBB ubiquitin B
UBE2D1 ubiquitin-conjugating enzyme E2D 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP36 ZFP36 ring finger protein
ZNF473 zinc finger protein 473
ZNF804A zinc finger protein 804A

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARL4A ADP-ribosylation factor-like 4A
B3GNT1
BBS10 Bardet-Biedl syndrome 10
BCAR3 breast cancer anti-estrogen resistance 3
BHLHE41 basic helix-loop-helix family, member e41
BOLA1 bolA family member 1
C11ORF68 chromosome 11 open reading frame 68
CAPN5 calpain 5
CBR4 carbonyl reductase 4
CEMIP cell migration inducing protein, hyaluronan binding
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTAGE9 CTAGE family, member 9
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
DEPDC1 DEP domain containing 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
ERF Ets2 repressor factor
FADD Fas (TNFRSF6)-associated via death domain
FJX1 four jointed box 1 (Drosophila)
FZD2 frizzled class receptor 2
FZD8 frizzled class receptor 8
GLI3 GLI family zinc finger 3
GRHL2 grainyhead-like 2 (Drosophila)
GRPR gastrin-releasing peptide receptor
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HAS2 hyaluronan synthase 2
HDAC7 histone deacetylase 7
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIST1H2AC histone cluster 1, H2ac
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
HYAL2 hyaluronoglucosaminidase 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL33 interleukin 33
INHBB inhibin, beta B
KIFC1 kinesin family member C1
KLF10 Kruppel-like factor 10
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LPAR6 lysophosphatidic acid receptor 6
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MCM3AP-AS1 MCM3AP antisense RNA 1
MNT MAX network transcriptional repressor
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NPR3 natriuretic peptide receptor 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PEX11B peroxisomal biogenesis factor 11 beta
PHC2 polyhomeotic homolog 2 (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIAS3 protein inhibitor of activated STAT, 3
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSRC1 proline/serine-rich coiled-coil 1
PTGFR prostaglandin F receptor (FP)
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
RAB20 RAB20, member RAS oncogene family
RANBP6 RAN binding protein 6
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RIN2 Ras and Rab interactor 2
RSAD1 radical S-adenosyl methionine domain containing 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SETD6 SET domain containing 6
SHROOM2 shroom family member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPATA7 spermatogenesis associated 7
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST5 suppression of tumorigenicity 5
STX1A syntaxin 1A (brain)
TENM4 teneurin transmembrane protein 4
TMEM177 transmembrane protein 177
TMEM187 transmembrane protein 187
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN15 tetraspanin 15
VASP vasodilator-stimulated phosphoprotein
WDR5B WD repeat domain 5B
ZBED8 zinc finger, BED-type containing 8
ZHX2 zinc fingers and homeoboxes 2
ZNF248 zinc finger protein 248
ZNF33B zinc finger protein 33B