MDA-MB-453 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
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218 genes mutated in the MDA-MB-453 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ADCK3 aarF domain containing kinase 3
AKAP8L A kinase (PRKA) anchor protein 8-like
ALG11 ALG11, alpha-1,2-mannosyltransferase
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANAPC5 anaphase promoting complex subunit 5
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
AR androgen receptor
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARFGEF3 ARFGEF family member 3
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASMTL acetylserotonin O-methyltransferase-like
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN7 ataxin 7
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRAP BRCA1 associated protein
BRD4 bromodomain containing 4
C12ORF73 chromosome 12 open reading frame 73
C5ORF28 chromosome 5 open reading frame 28
CAB39 calcium binding protein 39
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMTA2 calmodulin binding transcription activator 2
CANX calnexin
CCDC124 coiled-coil domain containing 124
CCDC132 coiled-coil domain containing 132
CCDC77 coiled-coil domain containing 77
CCSER1 coiled-coil serine-rich protein 1
CDC40 cell division cycle 40
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CES2 carboxylesterase 2
CHD8 chromodomain helicase DNA binding protein 8
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CINP cyclin-dependent kinase 2 interacting protein
CMTR1 cap methyltransferase 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CORO7 coronin 7
CORO7-PAM16 CORO7-PAM16 readthrough
CPNE1 copine I
CREB1 cAMP responsive element binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CUL9 cullin 9
DCAKD dephospho-CoA kinase domain containing
DIS3L DIS3 like exosome 3'-5' exoribonuclease
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DPYD dihydropyrimidine dehydrogenase
ELOVL1 ELOVL fatty acid elongase 1
ESRP2 epithelial splicing regulatory protein 2
ESYT1 extended synaptotagmin-like protein 1
EVPL envoplakin
EXOC2 exocyst complex component 2
FAM120C family with sequence similarity 120C
FAM193A family with sequence similarity 193, member A
FAM208B family with sequence similarity 208, member B
FAM83D family with sequence similarity 83, member D
FANCE Fanconi anemia, complementation group E
FBXL19 F-box and leucine-rich repeat protein 19
FGFR1OP FGFR1 oncogene partner
FGFR4 fibroblast growth factor receptor 4
FKBP8 FK506 binding protein 8, 38kDa
GBA2 glucosidase, beta (bile acid) 2
GTF2B general transcription factor IIB
GTPBP3 GTP binding protein 3 (mitochondrial)
HN1L hematological and neurological expressed 1-like
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HYAL3 hyaluronoglucosaminidase 3
IFT88 intraflagellar transport 88
IGF2R insulin-like growth factor 2 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT6B K(lysine) acetyltransferase 6B
KDM3B lysine (K)-specific demethylase 3B
KIAA0586 KIAA0586
KIAA1217 KIAA1217
KIF20B kinesin family member 20B
KLHDC2 kelch domain containing 2
L3MBTL2 l(3)mbt-like 2 (Drosophila)
LBR lamin B receptor
LNPEP leucyl/cystinyl aminopeptidase
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MACF1 microtubule-actin crosslinking factor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAST2 microtubule associated serine/threonine kinase 2
MBD6 methyl-CpG binding domain protein 6
MED21 mediator complex subunit 21
METTL13 methyltransferase like 13
METTL22 methyltransferase like 22
MFSD1 major facilitator superfamily domain containing 1
MGST3 microsomal glutathione S-transferase 3
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMS22L MMS22-like, DNA repair protein
MON1B MON1 secretory trafficking family member B
MRPS16 mitochondrial ribosomal protein S16
MSL2 male-specific lethal 2 homolog (Drosophila)
MYO19 myosin XIX
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAP1L4 nucleosome assembly protein 1-like 4
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAM2 neural cell adhesion molecule 2
NES nestin
NUP98 nucleoporin 98kDa
NUPR1 nuclear protein, transcriptional regulator, 1
ORC1 origin recognition complex, subunit 1
OSBPL11 oxysterol binding protein-like 11
OSBPL3 oxysterol binding protein-like 3
PCNX pecanex homolog (Drosophila)
PDIA3 protein disulfide isomerase family A, member 3
PDLIM5 PDZ and LIM domain 5
PHF3 PHD finger protein 3
PHKB phosphorylase kinase, beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKP3 plakophilin 3
PNPT1 polyribonucleotide nucleotidyltransferase 1
POLQ polymerase (DNA directed), theta
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPAN peter pan homolog (Drosophila)
PPAN-P2RY11 PPAN-P2RY11 readthrough
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP6R1 protein phosphatase 6, regulatory subunit 1
PROM2 prominin 2
PTDSS2 phosphatidylserine synthase 2
PUS3 pseudouridylate synthase 3
RB1CC1 RB1-inducible coiled-coil 1
RBM15 RNA binding motif protein 15
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSF1 remodeling and spacing factor 1
RUNX1 runt-related transcription factor 1
SART3 squamous cell carcinoma antigen recognized by T cells 3
SEC24C SEC24 family member C
SIK3 SIK family kinase 3
SIRT2 sirtuin 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
SLC38A6 solute carrier family 38, member 6
SMTN smoothelin
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNX2 sorting nexin 2
SPATA2 spermatogenesis associated 2
SPG11 spastic paraplegia 11 (autosomal recessive)
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SRCAP Snf2-related CREBBP activator protein
SRRM2 serine/arginine repetitive matrix 2
SSRP1 structure specific recognition protein 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAU2 staufen double-stranded RNA binding protein 2
STK4 serine/threonine kinase 4
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYMPK symplekin
SYNGAP1 synaptic Ras GTPase activating protein 1
SYNJ1 synaptojanin 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TATDN3 TatD DNase domain containing 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TEAD3 TEA domain family member 3
TECPR1 tectonin beta-propeller repeat containing 1
TEX2 testis expressed 2
THADA thyroid adenoma associated
THBS3 thrombospondin 3
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TLN1 talin 1
TMED8 transmembrane emp24 protein transport domain containing 8
TMEM187 transmembrane protein 187
TMEM8B transmembrane protein 8B
TNS2 tensin 2
TONSL tonsoku-like, DNA repair protein
TOP3B topoisomerase (DNA) III beta
TP53BP1 tumor protein p53 binding protein 1
TRAK2 trafficking protein, kinesin binding 2
TROAP trophinin associated protein
TSSK2 testis-specific serine kinase 2
TTC33 tetratricopeptide repeat domain 33
TTC39C tetratricopeptide repeat domain 39C
TTLL5 tubulin tyrosine ligase-like family member 5
UBE3A ubiquitin protein ligase E3A
UBE3B ubiquitin protein ligase E3B
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UBXN2B UBX domain protein 2B
UFSP2 UFM1-specific peptidase 2
UHMK1 U2AF homology motif (UHM) kinase 1
UNK unkempt family zinc finger
URGCP upregulator of cell proliferation
USP19 ubiquitin specific peptidase 19
USP33 ubiquitin specific peptidase 33
USP38 ubiquitin specific peptidase 38
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WWC1 WW and C2 domain containing 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XPR1 xenotropic and polytropic retrovirus receptor 1
YLPM1 YLP motif containing 1
YY1AP1 YY1 associated protein 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF10 zinc finger protein 10
ZNF121 zinc finger protein 121
ZNF213 zinc finger protein 213
ZNF22 zinc finger protein 22
ZNF274 zinc finger protein 274
ZNF318 zinc finger protein 318
ZNF346 zinc finger protein 346
ZNF711 zinc finger protein 711
ZNF846 zinc finger protein 846
ZSCAN32 zinc finger and SCAN domain containing 32