MDA-MB-453 cell Gene Set

Dataset ProteomicsDB Cell Type and Tissue Protein Expression Profiles
Category proteomics
Type cell type or tissue
Description Human breast carcinoma cell line; established from an effusion of a 48-year-old woman with breast carcinoma in 1976. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001908)
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Genes

268 proteins with high or low expression in MDA-MB-453 cell relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset.

high expression

Symbol Name Standardized Value
COPS5 COP9 signalosome subunit 5 2.51926
MAP2K1 mitogen-activated protein kinase kinase 1 2.21704
MMGT1 membrane magnesium transporter 1 2.18809
SDF2L1 stromal cell-derived factor 2-like 1 2.16164
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 2.03375
RAB1B RAB1B, member RAS oncogene family 1.99097
MRPL50 mitochondrial ribosomal protein L50 1.96953
C20ORF27 chromosome 20 open reading frame 27 1.95382
PCBP2 poly(rC) binding protein 2 1.89637
APOA1BP apolipoprotein A-I binding protein 1.79486
MRPS16 mitochondrial ribosomal protein S16 1.7367
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 1.66973
EXOC8 exocyst complex component 8 1.65025
PREB prolactin regulatory element binding 1.64025
PHB prohibitin 1.62939
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 1.60193
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 1.58031
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.57624
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 1.5548
TUBB tubulin, beta class I 1.52955
PTGES3 prostaglandin E synthase 3 (cytosolic) 1.51451
MPDU1 mannose-P-dolichol utilization defect 1 1.4937
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 1.45412
LMF2 lipase maturation factor 2 1.41983
SGPL1 sphingosine-1-phosphate lyase 1 1.41557
G6PD glucose-6-phosphate dehydrogenase 1.41149
COPS2 COP9 signalosome subunit 2 1.40234
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 1.40091
ATG5 autophagy related 5 1.38771
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.38712
CDK5 cyclin-dependent kinase 5 1.38595
KATNAL2 katanin p60 subunit A-like 2 1.3748
NME3 NME/NM23 nucleoside diphosphate kinase 3 1.35629
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 1.35464
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 1.34814
ERMP1 endoplasmic reticulum metallopeptidase 1 1.33694
OLA1 Obg-like ATPase 1 1.32561
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 1.32378
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 1.32016
CHID1 chitinase domain containing 1 1.31669
HN1L hematological and neurological expressed 1-like 1.31537
VKORC1 vitamin K epoxide reductase complex, subunit 1 1.30645
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.30375
GRB2 growth factor receptor-bound protein 2 1.30353
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 1.30301
TOLLIP toll interacting protein 1.2933
MTX2 metaxin 2 1.27508
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.25152
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 1.25103
PGP phosphoglycolate phosphatase 1.24208
GAK cyclin G associated kinase 1.23623
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 1.22709
TMED2 transmembrane emp24 domain trafficking protein 2 1.22071
ERP29 endoplasmic reticulum protein 29 1.21384
UBXN4 UBX domain protein 4 1.20393
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 1.20217
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.19639
APRT adenine phosphoribosyltransferase 1.19586
MAPK14 mitogen-activated protein kinase 14 1.19032
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 1.18554
GAPVD1 GTPase activating protein and VPS9 domains 1 1.18239
GOSR2 golgi SNAP receptor complex member 2 1.17559
RPLP1 ribosomal protein, large, P1 1.17298
PHB2 prohibitin 2 1.15154
COMT catechol-O-methyltransferase 1.15106
SAMM50 SAMM50 sorting and assembly machinery component 1.13896
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 1.13106
MVK mevalonate kinase 1.12931
EDC4 enhancer of mRNA decapping 4 1.12887
SORD sorbitol dehydrogenase 1.12873
CSE1L CSE1 chromosome segregation 1-like (yeast) 1.12636
IMMT inner membrane protein, mitochondrial 1.12189
SCYL1 SCY1-like 1 (S. cerevisiae) 1.12102
UQCRC2 ubiquinol-cytochrome c reductase core protein II 1.11853
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 1.11705
RALB v-ral simian leukemia viral oncogene homolog B 1.11236
MAP2K2 mitogen-activated protein kinase kinase 2 1.10947
PABPC1 poly(A) binding protein, cytoplasmic 1 1.1088
IDI1 isopentenyl-diphosphate delta isomerase 1 1.10624
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 1.10266
AP1B1 adaptor-related protein complex 1, beta 1 subunit 1.09638
FAM50A family with sequence similarity 50, member A 1.08964
ISOC1 isochorismatase domain containing 1 1.08805
DTYMK deoxythymidylate kinase (thymidylate kinase) 1.08667
RAB6A RAB6A, member RAS oncogene family 1.08032
COPS6 COP9 signalosome subunit 6 1.07959
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 1.07375
KRT1 keratin 1, type II 1.06912
GMPPB GDP-mannose pyrophosphorylase B 1.06114
PTK2 protein tyrosine kinase 2 1.05271
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 1.0482
DHRS7 dehydrogenase/reductase (SDR family) member 7 1.04217
CORO1B coronin, actin binding protein, 1B 1.04145
THEM6 thioesterase superfamily member 6 1.03761
PPIB peptidylprolyl isomerase B (cyclophilin B) 1.03468
MAPK15 mitogen-activated protein kinase 15 1.0301
PTRH2 peptidyl-tRNA hydrolase 2 1.02806
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 1.02429
HNRNPL heterogeneous nuclear ribonucleoprotein L 1.02099
MRPL19 mitochondrial ribosomal protein L19 1.01709
PTDSS1 phosphatidylserine synthase 1 1.01079
GPI glucose-6-phosphate isomerase 1.00386
DHCR7 7-dehydrocholesterol reductase 1.00112
CPNE3 copine III 0.99965
VDAC1 voltage-dependent anion channel 1 0.999246
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.996914
MRPL13 mitochondrial ribosomal protein L13 0.989509
RAB5B RAB5B, member RAS oncogene family 0.974036
CSNK2B casein kinase 2, beta polypeptide 0.972648
GSK3B glycogen synthase kinase 3 beta 0.968614
EIF3E eukaryotic translation initiation factor 3, subunit E 0.96765
GGCT gamma-glutamylcyclotransferase 0.963432
ADI1 acireductone dioxygenase 1 0.960179
SCFD1 sec1 family domain containing 1 0.950519
MRPL46 mitochondrial ribosomal protein L46 0.948378
CETN2 centrin, EF-hand protein, 2 0.944648
LMAN2 lectin, mannose-binding 2 0.943022
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.942538
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.939769
ARMC1 armadillo repeat containing 1 0.93841
COG5 component of oligomeric golgi complex 5 0.937548
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.935849
MRPL17 mitochondrial ribosomal protein L17 0.935386
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.930798
CDC23 cell division cycle 23 0.928616
C2CD5 C2 calcium-dependent domain containing 5 0.926698
SNX2 sorting nexin 2 0.92249
BLVRB biliverdin reductase B 0.921666
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.921457
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.920775
LACTB2 lactamase, beta 2 0.920644
PYCRL pyrroline-5-carboxylate reductase-like 0.919975
TUBB4A tubulin, beta 4A class IVa 0.916252
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.912855
ANKRD28 ankyrin repeat domain 28 0.909876
MAPK1 mitogen-activated protein kinase 1 0.90917
ACSL1 acyl-CoA synthetase long-chain family member 1 0.909069
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.906402
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.8998
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.897616
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.894722
CSK c-src tyrosine kinase 0.89392
TALDO1 transaldolase 1 0.89209
LYPLA1 lysophospholipase I 0.890674
GSK3A glycogen synthase kinase 3 alpha 0.8867
SCYL2 SCY1-like 2 (S. cerevisiae) 0.882511
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.882185
STAMBP STAM binding protein 0.880731
COMMD8 COMM domain containing 8 0.878724
TXN2 thioredoxin 2 0.877522
TOR1AIP2 torsin A interacting protein 2 0.874731
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.872938
DYNLRB1 dynein, light chain, roadblock-type 1 0.87292
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.869977
RPN2 ribophorin II 0.866027
ENOPH1 enolase-phosphatase 1 0.865754
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.863761
PSPC1 paraspeckle component 1 0.863102
COPS4 COP9 signalosome subunit 4 0.86267
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.861563
CDK2 cyclin-dependent kinase 2 0.856461
GLRX3 glutaredoxin 3 0.849149
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 0.848248
HSPA8 heat shock 70kDa protein 8 0.847595
STX5 syntaxin 5 0.845928
SRSF6 serine/arginine-rich splicing factor 6 0.843961
HEATR5B HEAT repeat containing 5B 0.842924
VAC14 Vac14 homolog (S. cerevisiae) 0.840846
NFS1 NFS1 cysteine desulfurase 0.840162
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.839495
TSTA3 tissue specific transplantation antigen P35B 0.837389
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.835151
NCSTN nicastrin 0.834886
SCAMP4 secretory carrier membrane protein 4 0.833869
PLXNB2 plexin B2 0.833701
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.828371

low expression

Symbol Name Standardized Value
COX20 COX20 cytochrome c oxidase assembly factor -2.53652
MGST3 microsomal glutathione S-transferase 3 -2.34827
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.31374
C9ORF78 chromosome 9 open reading frame 78 -2.22995
PEA15 phosphoprotein enriched in astrocytes 15 -2.1598
PDCD10 programmed cell death 10 -2.14631
MACF1 microtubule-actin crosslinking factor 1 -2.06105
ANXA1 annexin A1 -2.05356
NELFE negative elongation factor complex member E -1.95925
RCN2 reticulocalbin 2, EF-hand calcium binding domain -1.90591
ARPP19 cAMP-regulated phosphoprotein, 19kDa -1.88851
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -1.82154
WTAP Wilms tumor 1 associated protein -1.79298
NCK1 NCK adaptor protein 1 -1.71472
MTMR6 myotubularin related protein 6 -1.69933
ATAD1 ATPase family, AAA domain containing 1 -1.6118
AGPS alkylglycerone phosphate synthase -1.59418
CLTA clathrin, light chain A -1.5347
CNOT11 CCR4-NOT transcription complex, subunit 11 -1.51793
UROD uroporphyrinogen decarboxylase -1.49718
ZCCHC8 zinc finger, CCHC domain containing 8 -1.49484
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -1.4756
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -1.32993
NIPBL Nipped-B homolog (Drosophila) -1.31639
RIF1 replication timing regulatory factor 1 -1.31575
PDLIM1 PDZ and LIM domain 1 -1.29086
SRSF10 serine/arginine-rich splicing factor 10 -1.2774
POLR1B polymerase (RNA) I polypeptide B, 128kDa -1.27249
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -1.24529
ATXN2 ataxin 2 -1.24499
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -1.23566
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -1.21708
BABAM1 BRISC and BRCA1 A complex member 1 -1.21121
XPO4 exportin 4 -1.21055
RFC1 replication factor C (activator 1) 1, 145kDa -1.20571
WNK1 WNK lysine deficient protein kinase 1 -1.19584
KPNA1 karyopherin alpha 1 (importin alpha 5) -1.18963
PNO1 partner of NOB1 homolog (S. cerevisiae) -1.18314
WDR33 WD repeat domain 33 -1.17619
ADPRHL2 ADP-ribosylhydrolase like 2 -1.15022
HNRNPK heterogeneous nuclear ribonucleoprotein K -1.14925
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -1.12887
TMEM30A transmembrane protein 30A -1.10663
FAM134C family with sequence similarity 134, member C -1.10394
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -1.08834
MDN1 MDN1, midasin homolog (yeast) -1.07382
C1QBP complement component 1, q subcomponent binding protein -1.06915
EBNA1BP2 EBNA1 binding protein 2 -1.06213
DENR density-regulated protein -1.06193
LDHB lactate dehydrogenase B -1.05924
ACAA2 acetyl-CoA acyltransferase 2 -1.05757
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -1.04136
ADD1 adducin 1 (alpha) -1.03851
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -1.02785
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -1.02213
EDF1 endothelial differentiation-related factor 1 -1.0091
EIF5A eukaryotic translation initiation factor 5A -0.992113
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -0.983048
CLASP2 cytoplasmic linker associated protein 2 -0.979955
TAOK3 TAO kinase 3 -0.97527
GCC2 GRIP and coiled-coil domain containing 2 -0.974564
STIM1 stromal interaction molecule 1 -0.968702
PITPNA phosphatidylinositol transfer protein, alpha -0.965285
PHF6 PHD finger protein 6 -0.959905
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.954512
CTBP1 C-terminal binding protein 1 -0.952921
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.951529
RPL13 ribosomal protein L13 -0.938906
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 -0.937111
SMNDC1 survival motor neuron domain containing 1 -0.932296
MAP2K4 mitogen-activated protein kinase kinase 4 -0.926836
TPM4 tropomyosin 4 -0.924426
PRPF38B pre-mRNA processing factor 38B -0.909016
RPRD1B regulation of nuclear pre-mRNA domain containing 1B -0.896104
ALDOC aldolase C, fructose-bisphosphate -0.895306
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.89465
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.888314
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -0.878563
SCAF4 SR-related CTD-associated factor 4 -0.874239
FAM192A family with sequence similarity 192, member A -0.871535
STAG2 stromal antigen 2 -0.870289
EPN1 epsin 1 -0.863882
FSCN1 fascin actin-bundling protein 1 -0.856492
RBM26 RNA binding motif protein 26 -0.853629
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.849859
BAG2 BCL2-associated athanogene 2 -0.84529
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -0.844751
SAP30BP SAP30 binding protein -0.839155
EIF4B eukaryotic translation initiation factor 4B -0.838293
ARHGAP18 Rho GTPase activating protein 18 -0.833023
RBM8A RNA binding motif protein 8A -0.83241
NCL nucleolin -0.8271
Funding