LY-294002-2699 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the LY-294002-2699 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ADGRF5 adhesion G protein-coupled receptor F5
AFF2 AF4/FMR2 family, member 2
ATF7 activating transcription factor 7
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BHMT2 betaine--homocysteine S-methyltransferase 2
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CALD1 caldesmon 1
CASR calcium-sensing receptor
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CHGA chromogranin A
COL9A3 collagen, type IX, alpha 3
CPT1A carnitine palmitoyltransferase 1A (liver)
CREM cAMP responsive element modulator
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DCAF15 DDB1 and CUL4 associated factor 15
DDR1 discoidin domain receptor tyrosine kinase 1
DGKE diacylglycerol kinase, epsilon 64kDa
EGR1 early growth response 1
EGR3 early growth response 3
ERICH1 glutamate-rich 1
FAM49A family with sequence similarity 49, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXO40 F-box protein 40
FOXO4 forkhead box O4
FZD1 frizzled class receptor 1
GAST gastrin
GH1 growth hormone 1
GLP1R glucagon-like peptide 1 receptor
GLRA2 glycine receptor, alpha 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GSTA1 glutathione S-transferase alpha 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2AM histone cluster 1, H2am
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNF1B HNF1 homeobox B
HOXA1 homeobox A1
HOXC13 homeobox C13
HOXD13 homeobox D13
ICOSLG inducible T-cell co-stimulator ligand
KIF3C kinesin family member 3C
KMT2A lysine (K)-specific methyltransferase 2A
KRT23 keratin 23, type I
LEPR leptin receptor
LIMK2 LIM domain kinase 2
MAB21L1 mab-21-like 1 (C. elegans)
MAU2 MAU2 sister chromatid cohesion factor
MEP1B meprin A, beta
MOBP myelin-associated oligodendrocyte basic protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MUC6 mucin 6, oligomeric mucus/gel-forming
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NPR1 natriuretic peptide receptor 1
NPR3 natriuretic peptide receptor 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
PAIP2B poly(A) binding protein interacting protein 2B
PCDH11Y protocadherin 11 Y-linked
PDE4DIP phosphodiesterase 4D interacting protein
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHF20L1 PHD finger protein 20-like 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
POU2F2 POU class 2 homeobox 2
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PSG3 pregnancy specific beta-1-glycoprotein 3
RAB27B RAB27B, member RAS oncogene family
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RFC1 replication factor C (activator 1) 1, 145kDa
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHO rhodopsin
SIPA1L1 signal-induced proliferation-associated 1 like 1
SMR3B submaxillary gland androgen regulated protein 3B
SPRR2B small proline-rich protein 2B
SSX3 synovial sarcoma, X breakpoint 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TCAF1 TRPM8 channel-associated factor 1
TESK1 testis-specific kinase 1
TNP2 transition protein 2 (during histone to protamine replacement)
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM25 tripartite motif containing 25
TRIM36 tripartite motif containing 36
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPS1 trichorhinophalangeal syndrome I
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
ZER1 zyg-11 related, cell cycle regulator
ZNF154 zinc finger protein 154
ZNF225 zinc finger protein 225
ZNF385D zinc finger protein 385D

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AMT aminomethyltransferase
ANKRD55 ankyrin repeat domain 55
ATF5 activating transcription factor 5
BAHCC1 BAH domain and coiled-coil containing 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
C11ORF30 chromosome 11 open reading frame 30
C22ORF29 chromosome 22 open reading frame 29
C5AR1 complement component 5a receptor 1
C8ORF44 chromosome 8 open reading frame 44
C9ORF91 chromosome 9 open reading frame 91
CABP2 calcium binding protein 2
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CEP131 centrosomal protein 131kDa
CFP complement factor properdin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
COL15A1 collagen, type XV, alpha 1
CRELD1 cysteine-rich with EGF-like domains 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSG cathepsin G
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
DDN dendrin
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEFB1 defensin, beta 1
DEPDC5 DEP domain containing 5
DHRS11 dehydrogenase/reductase (SDR family) member 11
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
FAM184A family with sequence similarity 184, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FOXN2 forkhead box N2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRS3 fibroblast growth factor receptor substrate 3
FZD4 frizzled class receptor 4
GIF gastric intrinsic factor (vitamin B synthesis)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HSPA1L heat shock 70kDa protein 1-like
IDI2-AS1 IDI2 antisense RNA 1
INHBE inhibin, beta E
JAM3 junctional adhesion molecule 3
KIAA1024 KIAA1024
KLF3 Kruppel-like factor 3 (basic)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMD2 LIM domain containing 2
MARC1 mitochondrial amidoxime reducing component 1
METTL1 methyltransferase like 1
MOCOS molybdenum cofactor sulfurase
MOCS3 molybdenum cofactor synthesis 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
OCLN occludin
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
ORM1 orosomucoid 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PADI2 peptidyl arginine deiminase, type II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDGFD platelet derived growth factor D
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRDM12 PR domain containing 12
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSAT1 phosphoserine aminotransferase 1
PUS1 pseudouridylate synthase 1
PYGB phosphorylase, glycogen; brain
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF122 ring finger protein 122
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SERINC5 serine incorporator 5
SH2D4A SH2 domain containing 4A
SH3PXD2A SH3 and PX domains 2A
SLC12A8 solute carrier family 12, member 8
SLC22A14 solute carrier family 22, member 14
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPATA2L spermatogenesis associated 2-like
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUOX sulfite oxidase
TBXAS1 thromboxane A synthase 1 (platelet)
TCTA T-cell leukemia translocation altered
TEC tec protein tyrosine kinase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM53 transmembrane protein 53
TRIB3 tribbles pseudokinase 3
WDR62 WD repeat domain 62
WT1-AS WT1 antisense RNA
ZNF276 zinc finger protein 276
ZNF74 zinc finger protein 74
ZNF749 zinc finger protein 749
ZNF768 zinc finger protein 768