LY-294002-2676 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the LY-294002-2676 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACBD4 acyl-CoA binding domain containing 4
AMDHD2 amidohydrolase domain containing 2
ARL4C ADP-ribosylation factor-like 4C
ATN1 atrophin 1
AURKA aurora kinase A
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BCORL1 BCL6 corepressor-like 1
BLZF1 basic leucine zipper nuclear factor 1
BTF3P11 basic transcription factor 3 pseudogene 11
CALD1 caldesmon 1
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CATSPERB catsper channel auxiliary subunit beta
CCDC57 coiled-coil domain containing 57
CCL13 chemokine (C-C motif) ligand 13
CDHR1 cadherin-related family member 1
CEP295 centrosomal protein 295kDa
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLIC2 chloride intracellular channel 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF17 DDB1 and CUL4 associated factor 17
DDAH2 dimethylarginine dimethylaminohydrolase 2
DGCR8 DGCR8 microprocessor complex subunit
EFNB2 ephrin-B2
EGR4 early growth response 4
EMP1 epithelial membrane protein 1
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FCMR Fc fragment of IgM receptor
FDXR ferredoxin reductase
FOXO4 forkhead box O4
GK3P glycerol kinase 3 pseudogene
GOLGA8A golgin A8 family, member A
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIPK3 homeodomain interacting protein kinase 3
HNF4A hepatocyte nuclear factor 4, alpha
HOXA1 homeobox A1
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXC4 homeobox C4
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFI6 interferon, alpha-inducible protein 6
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KCTD20 potassium channel tetramerization domain containing 20
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMF1 lipase maturation factor 1
LPP LIM domain containing preferred translocation partner in lipoma
LRP2 low density lipoprotein receptor-related protein 2
MKL2 MKL/myocardin-like 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYO7A myosin VIIA
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXN nucleoredoxin
PHACTR1 phosphatase and actin regulator 1
PHF8 PHD finger protein 8
PHTF2 putative homeodomain transcription factor 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCD1 phospholipase C, delta 1
PLCE1 phospholipase C, epsilon 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKCQ protein kinase C, theta
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PURG purine-rich element binding protein G
QKI QKI, KH domain containing, RNA binding
RBM42 RNA binding motif protein 42
RDX radixin
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS5 regulator of G-protein signaling 5
RHBDD3 rhomboid domain containing 3
RHOB ras homolog family member B
RPGRIP1L RPGRIP1-like
RTEL1 regulator of telomere elongation helicase 1
SAFB scaffold attachment factor B
SCN4A sodium channel, voltage gated, type IV alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SGK2 serum/glucocorticoid regulated kinase 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMAD5 SMAD family member 5
ST7L suppression of tumorigenicity 7 like
STAP1 signal transducing adaptor family member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNPO synaptopodin
TMEM63A transmembrane protein 63A
TRAFD1 TRAF-type zinc finger domain containing 1
TRD T cell receptor delta locus
UBE2I ubiquitin-conjugating enzyme E2I
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF34 zinc finger protein 34
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ADAM2 ADAM metallopeptidase domain 2
ADGB androglobin
APOC4 apolipoprotein C-IV
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ASGR2 asialoglycoprotein receptor 2
BCAR3 breast cancer anti-estrogen resistance 3
BTF3P12 basic transcription factor 3 pseudogene 12
C1RL complement component 1, r subcomponent-like
C22ORF46 chromosome 22 open reading frame 46
C7ORF69 chromosome 7 open reading frame 69
C8A complement component 8, alpha polypeptide
CA11 carbonic anhydrase XI
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CCL27 chemokine (C-C motif) ligand 27
CD82 CD82 molecule
CDON cell adhesion associated, oncogene regulated
CGA glycoprotein hormones, alpha polypeptide
CLCN2 chloride channel, voltage-sensitive 2
CLDN3 claudin 3
CNN1 calponin 1, basic, smooth muscle
CPNE7 copine VII
CPTP ceramide-1-phosphate transfer protein
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEFB1 defensin, beta 1
DTX2 deltex 2, E3 ubiquitin ligase
ELMO3 engulfment and cell motility 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM127B family with sequence similarity 127, member B
FBXL2 F-box and leucine-rich repeat protein 2
FGF23 fibroblast growth factor 23
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
FRMPD1 FERM and PDZ domain containing 1
FZD4 frizzled class receptor 4
GIF gastric intrinsic factor (vitamin B synthesis)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GPR68 G protein-coupled receptor 68
HIST1H3G histone cluster 1, H3g
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HPR haptoglobin-related protein
HYAL2 hyaluronoglucosaminidase 2
IDI2-AS1 IDI2 antisense RNA 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITGA10 integrin, alpha 10
KDM8 lysine (K)-specific demethylase 8
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KLF1 Kruppel-like factor 1 (erythroid)
KLF13 Kruppel-like factor 13
LIME1 Lck interacting transmembrane adaptor 1
LY6D lymphocyte antigen 6 complex, locus D
MNX1 motor neuron and pancreas homeobox 1
MRAS muscle RAS oncogene homolog
MRPS18C mitochondrial ribosomal protein S18C
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTSS1L metastasis suppressor 1-like
NAG18 NAG18 mRNA
NLGN1 neuroligin 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PKD2L2 polycystic kidney disease 2-like 2
PLA2G1B phospholipase A2, group IB (pancreas)
PLAT plasminogen activator, tissue
PRF1 perforin 1 (pore forming protein)
PRSS53 protease, serine, 53
RAB13 RAB13, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCD5 stearoyl-CoA desaturase 5
SETD1A SET domain containing 1A
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMR3A submaxillary gland androgen regulated protein 3A
SPATA1 spermatogenesis associated 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SV2A synaptic vesicle glycoprotein 2A
SYTL2 synaptotagmin-like 2
TAGLN transgelin
TCTN1 tectonic family member 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TIGD6 tigger transposable element derived 6
TMEM184B transmembrane protein 184B
TMEM212 transmembrane protein 212
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS2 tensin 2
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UPB1 ureidopropionase, beta
ZBTB25 zinc finger and BTB domain containing 25
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF219 zinc finger protein 219
ZNF408 zinc finger protein 408
ZNF623 zinc finger protein 623