LDL cholesterol Gene Set

Dataset GWAS Catalog SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol. (Experimental Factor Ontology, EFO_0004195)
External Link https://www.ebi.ac.uk/gwas/search?query=LDL cholesterol
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Genes

52 genes associated with the LDL cholesterol phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
LDLR low density lipoprotein receptor 2.63819
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.51062
APOB apolipoprotein B 2.27625
APOC1 apolipoprotein C-I 2.24106
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.76973
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 1.71909
SUGP1 SURP and G patch domain containing 1 1.58902
LDAH lipid droplet associated hydrolase 1.56715
PCSK9 proprotein convertase subtilisin/kexin type 9 1.54158
FADS1 fatty acid desaturase 1 1.41169
PSRC1 proline/serine-rich coiled-coil 1 1.33006
DOCK7 dedicator of cytokinesis 7 1.31363
TIMD4 T-cell immunoglobulin and mucin domain containing 4 1.29929
ZPR1 ZPR1 zinc finger 1.21361
LOC157273 uncharacterized LOC157273 1.14658
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 1.08247
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.07711
HNF1A HNF1 homeobox A 1.06753
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 1.0654
TOP1 topoisomerase (DNA) I 1.00661
MYLIP myosin regulatory light chain interacting protein 0.939467
USP24 ubiquitin specific peptidase 24 0.939467
HLA-DRA major histocompatibility complex, class II, DR alpha 0.932983
NPC1L1 NPC1-like 1 0.870394
NYNRIN NYN domain and retroviral integrase containing 0.841354
TMEM57 transmembrane protein 57 0.802698
DNAH11 dynein, axonemal, heavy chain 11 0.781677
HFE hemochromatosis 0.770629
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.765464
FADS2 fatty acid desaturase 2 0.734471
PLEC plectin 0.734471
CSNK1G3 casein kinase 1, gamma 3 0.679413
LINC01132 long intergenic non-protein coding RNA 1132 0.658916
APOH apolipoprotein H (beta-2-glycoprotein I) 0.656287
BRCA2 breast cancer 2, early onset 0.637972
MARC1 mitochondrial amidoxime reducing component 1 0.612268
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.499091
APOE apolipoprotein E 0.499091
VLDLR very low density lipoprotein receptor 0.499091
FRK fyn-related Src family tyrosine kinase 0.483518
LOC102724968 uncharacterized LOC102724968 0.472799
EFCAB13 EF-hand calcium binding domain 13 0.472799
ANXA9 annexin A9 0.463473
EHBP1 EH domain binding protein 1 0.455873
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 0.434785
MTMR3 myotubularin related protein 3 0.434785
DOK7 docking protein 7 0.405958
COL11A2 collagen, type XI, alpha 2 0.369252
CR1L complement component (3b/4b) receptor 1-like 0.314454
AR androgen receptor 0.314454
GCKR glucokinase (hexokinase 4) regulator 0.266721
ZNF101 zinc finger protein 101 0.129504