JAK/STAT signaling pathway Gene Set

Dataset PANTHER Pathways
Category structural or functional annotations
Type pathway
Description The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand triggered signaling through the various receptors. (Pathway Ontology, PW_0000209)
External Link http://www.pantherdb.org/pathway/pathDetail.do?clsAccession=P00038
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Genes

14 proteins participating in the JAK/STAT signaling pathway pathway from the PANTHER Pathways dataset.

Symbol Name
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PTPRC protein tyrosine phosphatase, receptor type, C
SOCS1 suppressor of cytokine signaling 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced