Iron Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description disease cluster belonging to disease group metabolic (Genetic Association Database)
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Genes

154 genes associated with the trait Iron in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
TF transferrin 1.88798
TMPRSS6 transmembrane protease, serine 6 0.973188
HFE hemochromatosis 0.973188
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.796965
TFR2 transferrin receptor 2 0.667558
TTC7B tetratricopeptide repeat domain 7B 0.468051
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.383346
LRRC16A leucine rich repeat containing 16A 0.356676
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.271201
STOM stomatin 0.262417
GRM7 glutamate receptor, metabotropic 7 0.23769
SLC44A3 solute carrier family 44, member 3 0.232399
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.130512
PTPRM protein tyrosine phosphatase, receptor type, M 0.123388
LINC00189 long intergenic non-protein coding RNA 189 0.117717
CAPN13 calpain 13 0.117136
TGFBI transforming growth factor, beta-induced, 68kDa 0.109598
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.10877
LPL lipoprotein lipase 0.076992
CTIF CBP80/20-dependent translation initiation factor 0.068655
CD109 CD109 molecule 0.063827
NELL1 NEL-like 1 (chicken) 0.06252
ZNF592 zinc finger protein 592 0.053897
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.046651
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.041244
MRFAP1L1 Morf4 family associated protein 1-like 1 0.036043
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.034773
CTTNBP2 cortactin binding protein 2 0.033206
IST1 increased sodium tolerance 1 homolog (yeast) 0.031355
LIPC lipase, hepatic 0.028196
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.027709
FAM13A family with sequence similarity 13, member A 0.02463
GRM1 glutamate receptor, metabotropic 1 0.024378
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.024179
TSHZ3 teashirt zinc finger homeobox 3 0.023242
NCS1 neuronal calcium sensor 1 0.022794
F13A1 coagulation factor XIII, A1 polypeptide 0.022202
MOB3B MOB kinase activator 3B 0.022024
MYO10 myosin X 0.021854
SIRPB2 signal-regulatory protein beta 2 0.021668
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.02135
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.021099
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.020934
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.020672
LRTM2 leucine-rich repeats and transmembrane domains 2 0.020672
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 0.019987
CHSY3 chondroitin sulfate synthase 3 0.019812
ATXN7L1 ataxin 7-like 1 0.019666
ALMS1 Alstrom syndrome protein 1 0.019506
WRN Werner syndrome, RecQ helicase-like 0.019041
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.018408
PLXNC1 plexin C1 0.018404
ESD esterase D 0.018382
SHISA6 shisa family member 6 0.017516
CCDC162P coiled-coil domain containing 162, pseudogene 0.017407
TREM1 triggering receptor expressed on myeloid cells 1 0.017391
KCTD17 potassium channel tetramerization domain containing 17 0.017249
LPAR5 lysophosphatidic acid receptor 5 0.017174
THSD7A thrombospondin, type I, domain containing 7A 0.016999
FABP3 fatty acid binding protein 3, muscle and heart 0.016991
EDAR ectodysplasin A receptor 0.016849
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.016358
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.016281
MMRN1 multimerin 1 0.016205
NFASC neurofascin 0.016093
ALPK3 alpha-kinase 3 0.015787
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.01537
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.014575
ELMOD2 ELMO/CED-12 domain containing 2 0.014534
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.014341
NUMB numb homolog (Drosophila) 0.014185
KIF5C kinesin family member 5C 0.014176
SH3GL2 SH3-domain GRB2-like 2 0.014142
MRPL3 mitochondrial ribosomal protein L3 0.014025
PTPRD protein tyrosine phosphatase, receptor type, D 0.014001
PARK2 parkin RBR E3 ubiquitin protein ligase 0.013924
SOGA1 suppressor of glucose, autophagy associated 1 0.013924
SIM2 single-minded family bHLH transcription factor 2 0.0139
ADGB androglobin 0.013542
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.013372
GCM1 glial cells missing homolog 1 (Drosophila) 0.013277
TSPEAR thrombospondin-type laminin G domain and EAR repeats 0.012972
KRTAP10-4 keratin associated protein 10-4 0.012972
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.01286
NALCN sodium leak channel, non selective 0.012703
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 0.01262
CNTNAP5 contactin associated protein-like 5 0.012409
CHSY1 chondroitin sulfate synthase 1 0.012127
MEGF11 multiple EGF-like-domains 11 0.012114
KLHL14 kelch-like family member 14 0.012095
CFAP54 cilia and flagella associated 54 0.012095
OLFM1 olfactomedin 1 0.011875
EIF6 eukaryotic translation initiation factor 6 0.011321
SUGP1 SURP and G patch domain containing 1 0.010979
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.010953
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.010718
KDM4B lysine (K)-specific demethylase 4B 0.010037
PALLD palladin, cytoskeletal associated protein 0.010035
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 0.010013
CSMD1 CUB and Sushi multiple domains 1 0.009757
TBC1D27 TBC1 domain family, member 27 0.009458
C1ORF100 chromosome 1 open reading frame 100 0.009372
TENM3 teneurin transmembrane protein 3 0.009285
DLC1 DLC1 Rho GTPase activating protein 0.009199
FBXL13 F-box and leucine-rich repeat protein 13 0.00908
IGF1R insulin-like growth factor 1 receptor 0.008933
CLIC5 chloride intracellular channel 5 0.008833
FMN1 formin 1 0.008798
INADL InaD-like (Drosophila) 0.008787
FAM71B family with sequence similarity 71, member B 0.008498
GRIK2 glutamate receptor, ionotropic, kainate 2 0.008492
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.008444
TTC17 tetratricopeptide repeat domain 17 0.008439
ELF2P2 E74-like factor 2 pseudogene 2 0.008433
ZIC5 Zic family member 5 0.008422
ETV1 ets variant 1 0.008328
SGCZ sarcoglycan, zeta 0.008328
LRRC8A leucine rich repeat containing 8 family, member A 0.008237
TCF12 transcription factor 12 0.007718
PRPF18 pre-mRNA processing factor 18 0.007277
PTTG1 pituitary tumor-transforming 1 0.007204
NCOR2 nuclear receptor corepressor 2 0.007129
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.006934
NBAS neuroblastoma amplified sequence 0.006858
KLK14 kallikrein-related peptidase 14 0.006605
GLI3 GLI family zinc finger 3 0.006583
C9 complement component 9 0.006447
PLXNA1 plexin A1 0.006389
SUSD1 sushi domain containing 1 0.006383
CPN1 carboxypeptidase N, polypeptide 1 0.006371
METTL13 methyltransferase like 13 0.006363
PZP pregnancy-zone protein 0.006357
TGM5 transglutaminase 5 0.0063
RNF157 ring finger protein 157 0.006226
NBEA neurobeachin 0.006072
CORO2A coronin, actin binding protein, 2A 0.006032
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.005909
PARVA parvin, alpha 0.005657
SOX13 SRY (sex determining region Y)-box 13 0.005549
CPNE4 copine IV 0.005407
TMOD2 tropomodulin 2 (neuronal) 0.005169
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.005113
CCDC172 coiled-coil domain containing 172 0.005048
VIMP VCP-interacting membrane selenoprotein 0.005039
BCAS1 breast carcinoma amplified sequence 1 0.004889
CADPS Ca++-dependent secretion activator 0.004764
KIAA0319 KIAA0319 0.004687
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.004443
LTBP1 latent transforming growth factor beta binding protein 1 0.004186
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.004181
PRLR prolactin receptor 0.004129
TSHZ2 teashirt zinc finger homeobox 2 0.004038
DTNB dystrobrevin, beta 0.003965
ZNF12 zinc finger protein 12 0.003826