Insulin processing Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges. (Gene Ontology, GO_0030070)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-264876
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Genes

26 proteins participating in the Insulin processing pathway from the Reactome Pathways dataset.

Symbol Name
CPE carboxypeptidase E
CPN1 carboxypeptidase N, polypeptide 1
ERO1L ERO1-like (S. cerevisiae)
ERO1LB ERO1-like beta (S. cerevisiae)
EXOC1 exocyst complex component 1
EXOC2 exocyst complex component 2
EXOC3 exocyst complex component 3
EXOC4 exocyst complex component 4
EXOC5 exocyst complex component 5
EXOC6 exocyst complex component 6
EXOC7 exocyst complex component 7
EXOC8 exocyst complex component 8
INS insulin
KIF5A kinesin family member 5A
KIF5B kinesin family member 5B
KIF5C kinesin family member 5C
MYO5A myosin VA (heavy chain 12, myoxin)
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
RAB27A RAB27A, member RAS oncogene family
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC30A6 solute carrier family 30 (zinc transporter), member 6
SLC30A7 solute carrier family 30 (zinc transporter), member 7
SLC30A8 solute carrier family 30 (zinc transporter), member 8
STX1A syntaxin 1A (brain)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)