Insulin Resistance Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. (Human Phenotype Ontology, HP_0000855)
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Genes

58 genes associated with the trait Insulin Resistance in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
GCKR glucokinase (hexokinase 4) regulator 1.53555
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 1.35881
F9 coagulation factor IX 1.0945
IKZF2 IKAROS family zinc finger 2 (Helios) 0.872002
ANK2 ankyrin 2, neuronal 0.855042
ZP4 zona pellucida glycoprotein 4 0.839582
IGF1 insulin-like growth factor 1 (somatomedin C) 0.836775
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.800792
ACBD6 acyl-CoA binding domain containing 6 0.718708
ZNF286B zinc finger protein 286B 0.710177
ANK1 ankyrin 1, erythrocytic 0.641313
ADAM10 ADAM metallopeptidase domain 10 0.574155
C1ORF131 chromosome 1 open reading frame 131 0.542153
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.522576
TRRAP transformation/transcription domain-associated protein 0.467125
HHLA2 HERV-H LTR-associating 2 0.435571
CERS6 ceramide synthase 6 0.434002
PARK2 parkin RBR E3 ubiquitin protein ligase 0.40703
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.406869
ZFAND3 zinc finger, AN1-type domain 3 0.378873
FYN FYN proto-oncogene, Src family tyrosine kinase 0.367614
CCDC88C coiled-coil domain containing 88C 0.339437
SEZ6L seizure related 6 homolog (mouse)-like 0.33862
ALK anaplastic lymphoma receptor tyrosine kinase 0.338305
MBOAT1 membrane bound O-acyltransferase domain containing 1 0.327362
CCDC88A coiled-coil domain containing 88A 0.320512
CSMD1 CUB and Sushi multiple domains 1 0.310838
PITRM1 pitrilysin metallopeptidase 1 0.306492
CKS2 CDC28 protein kinase regulatory subunit 2 0.298415
CAPZB capping protein (actin filament) muscle Z-line, beta 0.294357
FAM63B family with sequence similarity 63, member B 0.285059
PFKP phosphofructokinase, platelet 0.280942
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.201297
FAM129A family with sequence similarity 129, member A 0.189029
FBXL17 F-box and leucine-rich repeat protein 17 0.185794
HOMER3 homer scaffolding protein 3 0.18437
PCDH9 protocadherin 9 0.175725
SCAI suppressor of cancer cell invasion 0.169567
GPA33 glycoprotein A33 (transmembrane) 0.163395
VWA8 von Willebrand factor A domain containing 8 0.156122
TSSC1 tumor suppressing subtransferable candidate 1 0.154004
ASB7 ankyrin repeat and SOCS box containing 7 0.149881
NT5DC1 5'-nucleotidase domain containing 1 0.132694
CAPN9 calpain 9 0.126594
LRRC4C leucine rich repeat containing 4C 0.118498
C9ORF3 chromosome 9 open reading frame 3 0.115914
TCP1P2 t-complex 1 pseudogene 2 0.111885
TNRC6B trinucleotide repeat containing 6B 0.108908
FSTL4 follistatin-like 4 0.10448
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.095184
UNC5C unc-5 homolog C (C. elegans) 0.085685
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.080993
SRPK2 SRSF protein kinase 2 0.074915
HELZ helicase with zinc finger 0.073635
LIPC lipase, hepatic 0.07289
EPHB2 EPH receptor B2 0.072842
UBE2N ubiquitin-conjugating enzyme E2N 0.071207
BFSP2 beaded filament structural protein 2, phakinin 0.061034