Inflammatory Bowel Diseases Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

260 genes associated with the Inflammatory Bowel Diseases phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANO6 anoctamin 6
AOX1 aldehyde oxidase 1
APC adenomatous polyposis coli
APOB apolipoprotein B
APOE apolipoprotein E
ARFRP1 ADP-ribosylation factor related protein 1
ARHGAP9 Rho GTPase activating protein 9
ARMS2 age-related maculopathy susceptibility 2
ATG10 autophagy related 10
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BANK1 B-cell scaffold protein with ankyrin repeats 1
BPI bactericidal/permeability-increasing protein
BRWD1 bromodomain and WD repeat domain containing 1
BSN bassoon presynaptic cytomatrix protein
BTNL2 butyrophilin-like 2
C11ORF30 chromosome 11 open reading frame 30
C1ORF106 chromosome 1 open reading frame 106
C2 complement component 2
C3 complement component 3
C5ORF56 chromosome 5 open reading frame 56
CADM2 cell adhesion molecule 2
CARD8 caspase recruitment domain family, member 8
CARD9 caspase recruitment domain family, member 9
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCNY cyclin Y
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD207 CD207 molecule, langerin
CD209 CD209 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLEC10A C-type lectin domain family 10, member A
CLEC16A C-type lectin domain family 16, member A
CLEC2D C-type lectin domain family 2, member D
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CUL2 cullin 2
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR1 chemokine (C-X-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DBP D site of albumin promoter (albumin D-box) binding protein
DCC DCC netrin 1 receptor
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB4A defensin, beta 4A
DLG5 discs, large homolog 5 (Drosophila)
DNAH12 dynein, axonemal, heavy chain 12
ECM1 extracellular matrix protein 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELMO1 engulfment and cell motility 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FAAH fatty acid amide hydrolase
FAF1 Fas (TNFRSF6) associated factor 1
FAM92B family with sequence similarity 92, member B
FAS Fas cell surface death receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCRL3 Fc receptor-like 3
FGB fibrinogen beta chain
FGFR1OP FGFR1 oncogene partner
FLG filaggrin
FSTL5 follistatin-like 5
FUT2 fucosyltransferase 2 (secretor status included)
GATA6 GATA binding protein 6
GCKR glucokinase (hexokinase 4) regulator
GLI1 GLI family zinc finger 1
GMPS guanine monphosphate synthase
GPC5 glypican 5
GRM8 glutamate receptor, metabotropic 8
GSDMB gasdermin B
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HNF4G hepatocyte nuclear factor 4, gamma
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
IBD5 inflammatory bowel disease 5
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IGSF6 immunoglobulin superfamily, member 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL17F interleukin 17F
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL23R interleukin 23 receptor
IL26 interleukin 26
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF5 interferon regulatory factor 5
IRGM immunity-related GTPase family, M
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
ITLN1 intelectin 1 (galactofuranose binding)
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JAK2 Janus kinase 2
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT38 keratin 38, type I
KRT8 keratin 8, type II
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LCT lactase
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LYRM4 LYR motif containing 4
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MEFV Mediterranean fever
MEP1A meprin A, alpha (PABA peptide hydrolase)
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MOCOS molybdenum cofactor sulfurase
MROH3P maestro heat-like repeat family member 3, pseudogene
MST1 macrophage stimulating 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUC19 mucin 19, oligomeric
MUTYH mutY homolog
MYDGF myeloid-derived growth factor
MYO9B myosin IXB
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NELL1 NEL-like 1 (chicken)
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKX2-3 NK2 homeobox 3
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NM neutrophil migration
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPSR1 neuropeptide S receptor 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OCTN3 organic cation transporter 3
OR2B11 olfactory receptor, family 2, subfamily B, member 11
OR5V1 olfactory receptor, family 5, subfamily V, member 1
PON1 paraoxonase 1
PON2 paraoxonase 2
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRDM1 PR domain containing 1, with ZNF domain
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTRF polymerase I and transcript release factor
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
REEP6 receptor accessory protein 6
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RSPH6A radial spoke head 6 homolog A (Chlamydomonas)
RUNX3 runt-related transcription factor 3
SBNO2 strawberry notch homolog 2 (Drosophila)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPD surfactant protein D
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC22A23 solute carrier family 22, member 23
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC38A9 solute carrier family 38, member 9
SMAD2 SMAD family member 2
SOCS5 suppressor of cytokine signaling 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX8 syntaxin 8
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNRC6C trinucleotide repeat containing 6C
TP53 tumor protein p53
TPMT thiopurine S-methyltransferase
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TTC7A tetratricopeptide repeat domain 7A
UBE2L3 ubiquitin-conjugating enzyme E2L 3
USP15 ubiquitin specific peptidase 15
USP25 ubiquitin specific peptidase 25
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XDH xanthine dehydrogenase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZGPAT zinc finger, CCCH-type with G patch domain
ZNF365 zinc finger protein 365