IC-86621-7518 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the IC-86621-7518 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK AHNAK nucleoprotein
ALPK1 alpha-kinase 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
BAIAP2 BAI1-associated protein 2
BTN2A1 butyrophilin, subfamily 2, member A1
C22ORF29 chromosome 22 open reading frame 29
C22ORF46 chromosome 22 open reading frame 46
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC93 coiled-coil domain containing 93
CDK3 cyclin-dependent kinase 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDV3 CDV3 homolog (mouse)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP164 centrosomal protein 164kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLN5 ceroid-lipofuscinosis, neuronal 5
CNOT4 CCR4-NOT transcription complex, subunit 4
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DZIP3 DAZ interacting zinc finger protein 3
EIF3M eukaryotic translation initiation factor 3, subunit M
ERN2 endoplasmic reticulum to nucleus signaling 2
ERP44 endoplasmic reticulum protein 44
FAM149B1 family with sequence similarity 149, member B1
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
FUBP1 far upstream element (FUSE) binding protein 1
GAREM GRB2 associated, regulator of MAPK1
GDF5 growth differentiation factor 5
HIST1H4D histone cluster 1, H4d
HSF1 heat shock transcription factor 1
IL11RA interleukin 11 receptor, alpha
IL1RAP interleukin 1 receptor accessory protein
JAK2 Janus kinase 2
KHSRP KH-type splicing regulatory protein
KLF12 Kruppel-like factor 12
LDB1 LIM domain binding 1
LMNA lamin A/C
LOC81691 exonuclease NEF-sp
LPAR6 lysophosphatidic acid receptor 6
LRRC6 leucine rich repeat containing 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MED18 mediator complex subunit 18
MED20 mediator complex subunit 20
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MTCP1 mature T-cell proliferation 1
NEK1 NIMA-related kinase 1
NFX1 nuclear transcription factor, X-box binding 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSMR oncostatin M receptor
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHGA8 protocadherin gamma subfamily A, 8
PDAP1 PDGFA associated protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PHF7 PHD finger protein 7
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTPRU protein tyrosine phosphatase, receptor type, U
QKI QKI, KH domain containing, RNA binding
RAB23 RAB23, member RAS oncogene family
RERE arginine-glutamic acid dipeptide (RE) repeats
RIMS2 regulating synaptic membrane exocytosis 2
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
SCARA3 scavenger receptor class A, member 3
SCN1B sodium channel, voltage gated, type I beta subunit
SCRN3 secernin 3
SERGEF secretion regulating guanine nucleotide exchange factor
SETD8 SET domain containing (lysine methyltransferase) 8
SKAP1 src kinase associated phosphoprotein 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SOD2 superoxide dismutase 2, mitochondrial
SPIDR scaffolding protein involved in DNA repair
SSH3 slingshot protein phosphatase 3
STOML1 stomatin (EPB72)-like 1
STS steroid sulfatase (microsomal), isozyme S
STX6 syntaxin 6
TCTN2 tectonic family member 2
TFCP2 transcription factor CP2
TMCO3 transmembrane and coiled-coil domains 3
TMEM8B transmembrane protein 8B
TRIM2 tripartite motif containing 2
TSPAN9 tetraspanin 9
USP6 ubiquitin specific peptidase 6
VPS13B vacuolar protein sorting 13 homolog B (yeast)
YIPF5 Yip1 domain family, member 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF318 zinc finger protein 318
ZNF41 zinc finger protein 41
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACVR2B activin A receptor, type IIB
AMDHD2 amidohydrolase domain containing 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ASIC3 acid sensing (proton gated) ion channel 3
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BMP4 bone morphogenetic protein 4
C5ORF30 chromosome 5 open reading frame 30
CBX8 chromobox homolog 8
CD5 CD5 molecule
CDIP1 cell death-inducing p53 target 1
CENPO centromere protein O
CLEC4E C-type lectin domain family 4, member E
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTFR ciliary neurotrophic factor receptor
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYSLTR2 cysteinyl leukotriene receptor 2
DDN dendrin
DISC1 disrupted in schizophrenia 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK1 dedicator of cytokinesis 1
DPY19L1P1 DPY19L1 pseudogene 1
DUSP9 dual specificity phosphatase 9
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ERF Ets2 repressor factor
FFAR3 free fatty acid receptor 3
GJC1 gap junction protein, gamma 1, 45kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOLGA2P5 golgin A2 pseudogene 5
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HOMER2 homer scaffolding protein 2
HOXC8 homeobox C8
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IPO8 importin 8
IQCC IQ motif containing C
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT86 keratin 86, type II
LHX6 LIM homeobox 6
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFGE8 milk fat globule-EGF factor 8 protein
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MORN1 MORN repeat containing 1
MX1 MX dynamin-like GTPase 1
NOL12 nucleolar protein 12
ONECUT2 one cut homeobox 2
PCDHA9 protocadherin alpha 9
PCDHB13 protocadherin beta 13
PEG3 paternally expressed 3
PGP phosphoglycolate phosphatase
PGPEP1 pyroglutamyl-peptidase I
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PQLC2 PQ loop repeat containing 2
PRICKLE3 prickle homolog 3 (Drosophila)
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROSER1 proline and serine rich 1
PRSS53 protease, serine, 53
QPCTL glutaminyl-peptide cyclotransferase-like
RAB36 RAB36, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RNF170 ring finger protein 170
SAG S-antigen; retina and pineal gland (arrestin)
SECISBP2 SECIS binding protein 2
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35F6 solute carrier family 35, member F6
SLITRK5 SLIT and NTRK-like family, member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPRYD7 SPRY domain containing 7
SSBP3 single stranded DNA binding protein 3
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNGR3 synaptogyrin 3
TASP1 taspase, threonine aspartase, 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNS2 tensin 2
TSNAXIP1 translin-associated factor X interacting protein 1
TTF2 transcription termination factor, RNA polymerase II
TUBA3C tubulin, alpha 3c
URGCP upregulator of cell proliferation
USP27X ubiquitin specific peptidase 27, X-linked
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VSIG10 V-set and immunoglobulin domain containing 10
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF408 zinc finger protein 408
ZNF446 zinc finger protein 446
ZNF749 zinc finger protein 749
ZNF778 zinc finger protein 778