Hypertension, Pulmonary Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006976
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Genes

275 genes/proteins associated with the disease Hypertension, Pulmonary from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
NOS3 nitric oxide synthase 3 (endothelial cell) 2.88009
EDN1 endothelin 1 2.88009
NPPB natriuretic peptide B 2.88009
TNF tumor necrosis factor 2.88009
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.88009
TPH1 tryptophan hydroxylase 1 2.88009
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.88009
CALCA calcitonin-related polypeptide alpha 2.88009
CBLN2 cerebellin 2 precursor 2.88009
ARG2 arginase 2 2.88009
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
CCL2 chemokine (C-C motif) ligand 2 2.88009
CCL1 chemokine (C-C motif) ligand 1 2.88009
TGFA transforming growth factor, alpha 2.88009
ALOX5 arachidonate 5-lipoxygenase 2.88009
CD40LG CD40 ligand 2.88009
CXCL8 chemokine (C-X-C motif) ligand 8 2.88009
FBLN5 fibulin 5 2.88009
CA9 carbonic anhydrase IX 2.88009
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.88009
PRKG1 protein kinase, cGMP-dependent, type I 2.88009
ACE angiotensin I converting enzyme 2.88009
GBA glucosidase, beta, acid 2.88009
EDNRB endothelin receptor type B 2.88009
SMAD9 SMAD family member 9 2.88009
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2.88009
IL6 interleukin 6 2.4176
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.3914
IL1B interleukin 1, beta 2.36156
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.34866
NOS2 nitric oxide synthase 2, inducible 2.31299
FOS FBJ murine osteosarcoma viral oncogene homolog 2.27547
VEGFA vascular endothelial growth factor A 2.24306
MAPK1 mitogen-activated protein kinase 1 2.20735
REN renin 2.19785
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.19649
CAT catalase 2.19109
BAX BCL2-associated X protein 2.18253
BCL2 B-cell CLL/lymphoma 2 2.16697
MAPK3 mitogen-activated protein kinase 3 2.15689
MMP9 matrix metallopeptidase 9 2.15588
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.08989
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.0644
NPPA natriuretic peptide A 2.06234
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.06064
TGFB1 transforming growth factor, beta 1 2.06003
TH tyrosine hydroxylase 1.98224
TP53 tumor protein p53 1.97552
FGF2 fibroblast growth factor 2 (basic) 1.95087
JUN jun proto-oncogene 1.9349
IL10 interleukin 10 1.93277
EDNRA endothelin receptor type A 1.93261
HMOX1 heme oxygenase 1 1.92944
CCND1 cyclin D1 1.92928
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.90574
MMP2 matrix metallopeptidase 2 1.88917
NOS1 nitric oxide synthase 1 (neuronal) 1.87675
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.87443
VCAM1 vascular cell adhesion molecule 1 1.85521
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.84126
BCL2L1 BCL2-like 1 1.83272
EGR1 early growth response 1 1.82359
FASLG Fas ligand (TNF superfamily, member 6) 1.82046
BDNF brain-derived neurotrophic factor 1.80378
COL1A1 collagen, type I, alpha 1 1.79408
CYCS cytochrome c, somatic 1.77686
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.77647
LEP leptin 1.77277
SOD1 superoxide dismutase 1, soluble 1.77024
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.75361
MPO myeloperoxidase 1.73455
IFNG interferon, gamma 1.72281
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.71009
GSK3B glycogen synthase kinase 3 beta 1.70595
NGF nerve growth factor (beta polypeptide) 1.70014
FAS Fas cell surface death receptor 1.68846
ICAM1 intercellular adhesion molecule 1 1.68612
IL1A interleukin 1, alpha 1.68422
F2 coagulation factor II (thrombin) 1.65555
PPARA peroxisome proliferator-activated receptor alpha 1.65159
TAC1 tachykinin, precursor 1 1.64033
EGFR epidermal growth factor receptor 1.63563
CXCL10 chemokine (C-X-C motif) ligand 10 1.63294
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.6249
GDNF glial cell derived neurotrophic factor 1.61805
TLR4 toll-like receptor 4 1.59849
AGTR2 angiotensin II receptor, type 2 1.58232
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.57688
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.5721
PPARG peroxisome proliferator-activated receptor gamma 1.56509
CRH corticotropin releasing hormone 1.56263
IL4 interleukin 4 1.56019
NPY neuropeptide Y 1.54693
TIMP1 TIMP metallopeptidase inhibitor 1 1.54014
PRL prolactin 1.53086
MKI67 marker of proliferation Ki-67 1.52963
AVP arginine vasopressin 1.52313
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.5123
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.5103
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.50373
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.50223
TIMP2 TIMP metallopeptidase inhibitor 2 1.50198
MMP3 matrix metallopeptidase 3 1.49992
PARP1 poly (ADP-ribose) polymerase 1 1.49508
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.49304
CREB1 cAMP responsive element binding protein 1 1.49045
PRKCD protein kinase C, delta 1.48633
POMC proopiomelanocortin 1.48376
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.46568
MAPK8 mitogen-activated protein kinase 8 1.46277
CXCL2 chemokine (C-X-C motif) ligand 2 1.46041
NFE2L2 nuclear factor, erythroid 2-like 2 1.4559
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.45063
BIRC5 baculoviral IAP repeat containing 5 1.44899
CCL3 chemokine (C-C motif) ligand 3 1.44599
OXT oxytocin/neurophysin I prepropeptide 1.43537
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.43401
IGF1 insulin-like growth factor 1 (somatomedin C) 1.4332
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.43293
CTGF connective tissue growth factor 1.43212
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.42994
JUNB jun B proto-oncogene 1.42885
IL12B interleukin 12B 1.42562
DDIT3 DNA-damage-inducible transcript 3 1.42374
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.42211
PECAM1 platelet/endothelial cell adhesion molecule 1 1.42101
APOE apolipoprotein E 1.41884
CLU clusterin 1.41229
TFRC transferrin receptor 1.40568
GPX1 glutathione peroxidase 1 1.39952
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.39451
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.39422
DUSP1 dual specificity phosphatase 1 1.38946
GFAP glial fibrillary acidic protein 1.38298
PLAU plasminogen activator, urokinase 1.38298
EPO erythropoietin 1.38242
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.37902
FASN fatty acid synthase 1.37874
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.3759
KNG1 kininogen 1 1.37561
SPP1 secreted phosphoprotein 1 1.36933
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.36706
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.3639
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.3639
ACTA2 actin, alpha 2, smooth muscle, aorta 1.3619
AGTR1 angiotensin II receptor, type 1 1.34897
COL3A1 collagen, type III, alpha 1 1.3484
MAP2K1 mitogen-activated protein kinase kinase 1 1.3414
DRD2 dopamine receptor D2 1.3414
MMP1 matrix metallopeptidase 1 1.33434
CNR1 cannabinoid receptor 1 (brain) 1.33316
FN1 fibronectin 1 1.3314
F3 coagulation factor III (thromboplastin, tissue factor) 1.32696
PLAT plasminogen activator, tissue 1.32577
CCND2 cyclin D2 1.32488
IL12A interleukin 12A 1.3228
GJA1 gap junction protein, alpha 1, 43kDa 1.31746
ACTB actin, beta 1.31237
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.30911
INS insulin 1.30911
TJP1 tight junction protein 1 1.3039
APP amyloid beta (A4) precursor protein 1.30056
ADIPOQ adiponectin, C1Q and collagen domain containing 1.2944
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.2944
ANGPT2 angiopoietin 2 1.28703
PRKCE protein kinase C, epsilon 1.27875
S100B S100 calcium binding protein B 1.27255
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.26917
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.267
ANXA5 annexin A5 1.26236
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.25682
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.25183
ANGPTL4 angiopoietin-like 4 1.24874
MAOA monoamine oxidase A 1.22916
SOCS3 suppressor of cytokine signaling 3 1.22696
NAMPT nicotinamide phosphoribosyltransferase 1.22274
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.21727
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.21695
CXCR4 chemokine (C-X-C motif) receptor 4 1.21663
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.21468
XBP1 X-box binding protein 1 1.21435
E2F1 E2F transcription factor 1 1.21239
CCL5 chemokine (C-C motif) ligand 5 1.20427
GNAS GNAS complex locus 1.20097
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.19574
FOXO3 forkhead box O3 1.19345
GSK3A glycogen synthase kinase 3 alpha 1.1862
ALB albumin 1.1862
ELK1 ELK1, member of ETS oncogene family 1.18456
COL1A2 collagen, type I, alpha 2 1.18059
LPL lipoprotein lipase 1.17563
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.173
PDGFB platelet-derived growth factor beta polypeptide 1.16833
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.166
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.16467
PENK proenkephalin 1.15899
MAOB monoamine oxidase B 1.15899
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.15797
MAPK9 mitogen-activated protein kinase 9 1.15458
ADRB2 adrenoceptor beta 2, surface 1.15256
CCNA2 cyclin A2 1.15022
ADRB1 adrenoceptor beta 1 1.14954
SIRT1 sirtuin 1 1.14885
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.14234
TRAF2 TNF receptor-associated factor 2 1.13929
PRKCA protein kinase C, alpha 1.13827
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.13655
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.13655
CRP C-reactive protein, pentraxin-related 1.12973
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.1294
HSPA8 heat shock 70kDa protein 8 1.12288
IL1RN interleukin 1 receptor antagonist 1.11877
OPRM1 opioid receptor, mu 1 1.11639
BAK1 BCL2-antagonist/killer 1 1.11431
DRD1 dopamine receptor D1 1.11431
IL18 interleukin 18 1.1129
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.1129
PTEN phosphatase and tensin homolog 1.1129
BAD BCL2-associated agonist of cell death 1.11116
BECN1 beclin 1, autophagy related 1.11046
SELE selectin E 1.10803
FOXO1 forkhead box O1 1.10769
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.10631
SGK1 serum/glucocorticoid regulated kinase 1 1.10388
NOX4 NADPH oxidase 4 1.09927
MCL1 myeloid cell leukemia 1 1.09332
SREBF1 sterol regulatory element binding transcription factor 1 1.0919
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.09119
IL2 interleukin 2 1.0869
MBP myelin basic protein 1.08337
CAV1 caveolin 1, caveolae protein, 22kDa 1.08196
BGLAP bone gamma-carboxyglutamate (gla) protein 1.08091
PDIA3 protein disulfide isomerase family A, member 3 1.07553
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.07411
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.07234
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.06698
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.06698
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.06625
PER1 period circadian clock 1 1.06515
PRDX2 peroxiredoxin 2 1.06297
LHB luteinizing hormone beta polypeptide 1.05972
FBN1 fibrillin 1 1.05864
PDGFA platelet-derived growth factor alpha polypeptide 1.05828
SELL selectin L 1.05828
IL13 interleukin 13 1.05312
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.05015
BID BH3 interacting domain death agonist 1.04904
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.04904
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.04831
EFNA1 ephrin-A1 1.04794
FBXO32 F-box protein 32 1.04465
DUSP8 dual specificity phosphatase 8 1.04014
RGS2 regulator of G-protein signaling 2 1.03864
ARC activity-regulated cytoskeleton-associated protein 1.03789
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.03715
CCNB1 cyclin B1 1.03567
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.03493
TIMP3 TIMP metallopeptidase inhibitor 3 1.03382
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.03159
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.03159
LDLR low density lipoprotein receptor 1.02783
THBS1 thrombospondin 1 1.02708
MMP8 matrix metallopeptidase 8 1.02559
CDK5 cyclin-dependent kinase 5 1.02522
RB1 retinoblastoma 1 1.02522
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.02188
ATF3 activating transcription factor 3 1.02188
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.02077
MAPK14 mitogen-activated protein kinase 14 1.02077
HPCA hippocalcin 1.01437
CCDC88A coiled-coil domain containing 88A 1.01361
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.01286
COX5A cytochrome c oxidase subunit Va 1.01137
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.01099