Head and Neck Neoplasms Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) (Experimental Factor Ontology, EFO_0004284)
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Genes

406 genes associated with the Head and Neck Neoplasms phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACVR1B activin A receptor, type IB
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AGO1 argonaute RISC catalytic component 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPT4 angiopoietin 4
ANGPTL1 angiopoietin-like 1
ANKK1 ankyrin repeat and kinase domain containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AR androgen receptor
ARID1A AT rich interactive domain 1A (SWI-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATG4A autophagy related 4A, cysteine peptidase
ATG9A autophagy related 9A
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AURKA aurora kinase A
AXIN2 axin 2
BAG1 BCL2-associated athanogene
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BHMT betaine--homocysteine S-methyltransferase
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BMF Bcl2 modifying factor
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
C19ORF45 chromosome 19 open reading frame 45
CA9 carbonic anhydrase IX
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD34 CD34 molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDC25C cell division cycle 25C
CDC7 cell division cycle 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLPTM1L CLPTM1-like
COL18A1 collagen, type XVIII, alpha 1
COMT catechol-O-methyltransferase
COX18 COX18 cytochrome c oxidase assembly factor
CSNK1E casein kinase 1, epsilon
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DEC1 deleted in esophageal cancer 1
DGCR8 DGCR8 microprocessor complex subunit
DICER1 dicer 1, ribonuclease type III
DLEC1 deleted in lung and esophageal cancer 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPYD dihydropyrimidine dehydrogenase
DRD2 dopamine receptor D2
DROSHA drosha, ribonuclease type III
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F7 E2F transcription factor 7
EGFR epidermal growth factor receptor
EMC8 ER membrane protein complex subunit 8
ENDOV endonuclease V
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERN1 endoplasmic reticulum to nucleus signaling 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FANCD2 Fanconi anemia, complementation group D2
FANCG Fanconi anemia, complementation group G
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FGF5 fibroblast growth factor 5
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FOXO1 forkhead box O1
FTO fat mass and obesity associated
FZD3 frizzled class receptor 3
FZD4 frizzled class receptor 4
GC group-specific component (vitamin D binding protein)
GEMIN4 gem (nuclear organelle) associated protein 4
GHITM growth hormone inducible transmembrane protein
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GJB5 gap junction protein, beta 5, 31.1kDa
GLI2 GLI family zinc finger 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPER1 G protein-coupled estrogen receptor 1
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GPX4 glutathione peroxidase 4
GPX7 glutathione peroxidase 7
GSTA2 glutathione S-transferase alpha 2
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HELQ helicase, POLQ-like
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2-AS IGF2 antisense RNA
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL10 interleukin 10
IL13 interleukin 13
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL6 interleukin 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KDM4C lysine (K)-specific demethylase 4C
KDR kinase insert domain receptor
KISS1 KiSS-1 metastasis-suppressor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LIMD1 LIM domains containing 1
LTBP1 latent transforming growth factor beta binding protein 1
LZTS1 leucine zipper, putative tumor suppressor 1
MAX MYC associated factor X
MBD1 methyl-CpG binding domain protein 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR1468 microRNA 1468
MIR146A microRNA 146a
MIR149 microRNA 149
MIR196A2 microRNA 196a-2
MIR27A microRNA 27a
MIR499A microRNA 499a
MKI67 marker of proliferation Ki-67
MLH3 mutL homolog 3
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPO myeloperoxidase
MRC2 mannose receptor, C type 2
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NF1 neurofibromin 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NHEJ1 nonhomologous end-joining factor 1
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOXA1 NADPH oxidase activator 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGRMC2 progesterone receptor membrane component 2
PHF2 PHD finger protein 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLCE1 phospholipase C, epsilon 1
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POLB polymerase (DNA directed), beta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLH polymerase (DNA directed), eta
POLK polymerase (DNA directed) kappa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PON1 paraoxonase 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROM1 prominin 1
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRS protein tyrosine phosphatase, receptor type, S
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAN RAN, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RB1 retinoblastoma 1
RECQL4 RecQ protein-like 4
RET ret proto-oncogene
RFC1 replication factor C (activator 1) 1, 145kDa
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS11 regulator of G-protein signaling 11
RGS12 regulator of G-protein signaling 12
RGS13 regulator of G-protein signaling 13
RGS14 regulator of G-protein signaling 14
RGS16 regulator of G-protein signaling 16
RGS18 regulator of G-protein signaling 18
RGS2 regulator of G-protein signaling 2
RGS20 regulator of G-protein signaling 20
RGS22 regulator of G-protein signaling 22
RGS3 regulator of G-protein signaling 3
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RGS7 regulator of G-protein signaling 7
RGS8 regulator of G-protein signaling 8
RGS9 regulator of G-protein signaling 9
RICTOR RPTOR independent companion of MTOR, complex 2
RING1 ring finger protein 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF2 ring finger protein 2
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRM1 ribonucleotide reductase M1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHAF2 succinate dehydrogenase complex assembly factor 2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SETD1A SET domain containing 1A
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIRT3 sirtuin 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMC1B structural maintenance of chromosomes 1B
SMO smoothened, frizzled class receptor
SNAI1 snail family zinc finger 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SUFU suppressor of fused homolog (Drosophila)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SULT4A1 sulfotransferase family 4A, member 1
TALDO1 transaldolase 1
TAS2R13 taste receptor, type 2, member 13
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TC2N tandem C2 domains, nuclear
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM127 transmembrane protein 127
TNF tumor necrosis factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53I3 tumor protein p53 inducible protein 3
TP73 tumor protein p73
TSC1 tuberous sclerosis 1
TXN2 thioredoxin 2
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT11 wingless-type MMTV integration site family, member 11
WNT2B wingless-type MMTV integration site family, member 2B
WRAP53 WD repeat containing, antisense to TP53
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XPO5 exportin 5
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6