HIV Infection Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description A Lentivirus infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_agent Human immunodeficiency virus 1 or has_agent Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.|Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).|An infection caused by the human immunodeficiency virus. (Experimental Factor Ontology, EFO_0000764)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-162906
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Genes

219 proteins participating in the HIV Infection pathway from the Reactome Pathways dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP1M2 adaptor-related protein complex 1, mu 2 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARF1 ADP-ribosylation factor 1
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
B2M beta-2-microglobulin
BANF1 barrier to autointegration factor 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCNH cyclin H
CCNT1 cyclin T1
CCNT2 cyclin T2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD247 CD247 molecule
CD28 CD28 molecule
CD4 CD4 molecule
CD8B CD8b molecule
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CHMP2A charged multivesicular body protein 2A
CHMP2B charged multivesicular body protein 2B
CHMP3 charged multivesicular body protein 3
CHMP4A charged multivesicular body protein 4A
CHMP4B charged multivesicular body protein 4B
CHMP4C charged multivesicular body protein 4C
CHMP5 charged multivesicular body protein 5
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL5 cullin 5
CXCR4 chemokine (C-X-C motif) receptor 4
DOCK2 dedicator of cytokinesis 2
ELL elongation factor RNA polymerase II
ELMO1 engulfment and cell motility 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
FEN1 flap structure-specific endonuclease 1
FURIN furin (paired basic amino acid cleaving enzyme)
FYN FYN proto-oncogene, Src family tyrosine kinase
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2A2 general transcription factor IIA, 2, 12kDa
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HCK HCK proto-oncogene, Src family tyrosine kinase
HLA-A major histocompatibility complex, class I, A
HMGA1 high mobility group AT-hook 1
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNB1 karyopherin (importin) beta 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
MNAT1 MNAT CDK-activating kinase assembly factor 1
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NELFCD negative elongation factor complex member C/D
NELFE negative elongation factor complex member E
NMT1 N-myristoyltransferase 1
NMT2 N-myristoyltransferase 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP153 nucleoporin 153kDa
NUP155 nucleoporin 155kDa
NUP160 nucleoporin 160kDa
NUP188 nucleoporin 188kDa
NUP205 nucleoporin 205kDa
NUP210 nucleoporin 210kDa
NUP214 nucleoporin 214kDa
NUP35 nucleoporin 35kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP50 nucleoporin 50kDa
NUP54 nucleoporin 54kDa
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUP88 nucleoporin 88kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NUPL2 nucleoporin like 2
PACS1 phosphofurin acidic cluster sorting protein 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDCD6IP programmed cell death 6 interacting protein
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POM121 POM121 transmembrane nucleoporin
PPIA peptidylprolyl isomerase A (cyclophilin A)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAE1 ribonucleic acid export 1
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCC1 regulator of chromosome condensation 1
RNGTT RNA guanylyltransferase and 5'-phosphatase
RNMT RNA (guanine-7-) methyltransferase
RPS27A ribosomal protein S27a
SEH1L SEH1-like (S. cerevisiae)
SKP1 S-phase kinase-associated protein 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SSRP1 structure specific recognition protein 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAT tyrosine aminotransferase
TBP TATA box binding protein
TCEA1 transcription elongation factor A (SII), 1
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TPR translocated promoter region, nuclear basket protein
TSG101 tumor susceptibility 101
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VTA1 vesicle (multivesicular body) trafficking 1
XPO1 exportin 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6