H-7-5941 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the H-7-5941 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALK anaplastic lymphoma receptor tyrosine kinase
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOC1 apolipoprotein C-I
APP amyloid beta (A4) precursor protein
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATXN7L1 ataxin 7-like 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAS1 breast carcinoma amplified sequence 1
BCCIP BRCA2 and CDKN1A interacting protein
BEX1 brain expressed, X-linked 1
BICD1 bicaudal D homolog 1 (Drosophila)
CAPN5 calpain 5
CASZ1 castor zinc finger 1
CCDC88C coiled-coil domain containing 88C
CDK14 cyclin-dependent kinase 14
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNTNAP3B contactin associated protein-like 3B
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSZ cathepsin Z
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYLD cylindromatosis (turban tumor syndrome)
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DDN dendrin
DHFR dihydrofolate reductase
ELK1 ELK1, member of ETS oncogene family
EPHB2 EPH receptor B2
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FCMR Fc fragment of IgM receptor
FDPS farnesyl diphosphate synthase
FH fumarate hydratase
FKBP10 FK506 binding protein 10, 65 kDa
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAL galanin/GMAP prepropeptide
GAS7 growth arrest-specific 7
GH1 growth hormone 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GRIP2 glutamate receptor interacting protein 2
HDLBP high density lipoprotein binding protein
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HMGN5 high mobility group nucleosome binding domain 5
HPN hepsin
IFI6 interferon, alpha-inducible protein 6
IL1RAP interleukin 1 receptor accessory protein
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0368 KIAA0368
KRT85 keratin 85, type II
LTBP4 latent transforming growth factor beta binding protein 4
MLF1 myeloid leukemia factor 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPPE1 metallophosphoesterase 1
MXD4 MAX dimerization protein 4
NEURL1 neuralized E3 ubiquitin protein ligase 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PI3 peptidase inhibitor 3, skin-derived
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG1 phospholipase C, gamma 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDX2 peroxiredoxin 2
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRR7 proline rich 7 (synaptic)
RHOQ ras homolog family member Q
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SH3BP2 SH3-domain binding protein 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLAMF7 SLAM family member 7
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SMC1A structural maintenance of chromosomes 1A
SP100 SP100 nuclear antigen
STAB2 stabilin 2
TAPBP TAP binding protein (tapasin)
TCP11L1 t-complex 11, testis-specific-like 1
THBS1 thrombospondin 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TK2 thymidine kinase 2, mitochondrial
TLE2 transducin-like enhancer of split 2
TREM1 triggering receptor expressed on myeloid cells 1
TUBA3D tubulin, alpha 3d
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
WDTC1 WD and tetratricopeptide repeats 1
WIZ widely interspaced zinc finger motifs
WWOX WW domain containing oxidoreductase
YY2 YY2 transcription factor
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
ADRB2 adrenoceptor beta 2, surface
ANKRD49 ankyrin repeat domain 49
ARF6 ADP-ribosylation factor 6
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BYSL bystin-like
C14ORF169 chromosome 14 open reading frame 169
C1ORF106 chromosome 1 open reading frame 106
CASP8AP2 caspase 8 associated protein 2
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CLP1 cleavage and polyadenylation factor I subunit 1
CSRNP2 cysteine-serine-rich nuclear protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FADD Fas (TNFRSF6)-associated via death domain
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FBXO5 F-box protein 5
FOSL1 FOS-like antigen 1
GCC1 GRIP and coiled-coil domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GPR87 G protein-coupled receptor 87
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
GUSBP3 glucuronidase, beta pseudogene 3
HAS2 hyaluronan synthase 2
HJURP Holliday junction recognition protein
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IP6K2 inositol hexakisphosphate kinase 2
JMJD1C jumonji domain containing 1C
LEMD3 LEM domain containing 3
LOC100272216 uncharacterized LOC100272216
MAD2L1BP MAD2L1 binding protein
MED17 mediator complex subunit 17
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MRFAP1L1 Morf4 family associated protein 1-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKRF NFKB repressing factor
NRBF2 nuclear receptor binding factor 2
NXT1 nuclear transport factor 2-like export factor 1
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK2 polo-like kinase 2
PNRC2 proline-rich nuclear receptor coactivator 2
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPAN peter pan homolog (Drosophila)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PTCD1 pentatricopeptide repeat domain 1
PTRH2 peptidyl-tRNA hydrolase 2
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RGS2 regulator of G-protein signaling 2
RIOK2 RIO kinase 2
RND3 Rho family GTPase 3
RNF139 ring finger protein 139
RPP38 ribonuclease P/MRP 38kDa subunit
RSBN1 round spermatid basic protein 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TRIM32 tripartite motif containing 32
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TTC4 tetratricopeptide repeat domain 4
WDR43 WD repeat domain 43
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBED5 zinc finger, BED-type containing 5
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF12 zinc finger protein 12
ZNF184 zinc finger protein 184
ZNF217 zinc finger protein 217
ZNF274 zinc finger protein 274
ZNF430 zinc finger protein 430
ZNF443 zinc finger protein 443
ZNF7 zinc finger protein 7