Glucose Intolerance Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

115 genes associated with the Glucose Intolerance phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY5 adenylate cyclase 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGMO alkylglycerol monooxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
APOC3 apolipoprotein C-III
ATF6 activating transcription factor 6
C2CD4B C2 calcium-dependent domain containing 4B
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPN10 calpain 10
CAT catalase
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CRY2 cryptochrome circadian clock 2
DGKB diacylglycerol kinase, beta 90kDa
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EXT2 exostosin glycosyltransferase 2
FADS1 fatty acid desaturase 1
FNDC5 fibronectin type III domain containing 5
FOXO1 forkhead box O1
FTO fat mass and obesity associated
FXN frataxin
G6PC2 glucose-6-phosphatase, catalytic, 2
GAS6 growth arrest-specific 6
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GIPR gastric inhibitory polypeptide receptor
GLIS3 GLIS family zinc finger 3
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL18 interleukin 18
IL6 interleukin 6
IL6R interleukin 6 receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAZF1 JAZF zinc finger 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KIF11 kinesin family member 11
LEPR leptin receptor
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LRP5 low density lipoprotein receptor-related protein 5
LTA lymphotoxin alpha
LTF lactotransferrin
MADD MAP-kinase activating death domain
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MBL2 mannose-binding lectin (protein C) 2, soluble
MOK MOK protein kinase
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-TL1 tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPPA natriuretic peptide A
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OGG1 8-oxoguanine DNA glycosylase
OPRM1 opioid receptor, mu 1
PAX6 paired box 6
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDX1 pancreatic and duodenal homeobox 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PROX1 prospero homeobox 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RBP4 retinol binding protein 4, plasma
SCG5 secretogranin V
SHBG sex hormone-binding globulin
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SREBF1 sterol regulatory element binding transcription factor 1
STX1A syntaxin 1A (brain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THADA thyroid adenoma associated
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TNMD tenomodulin
TSPAN8 tetraspanin 8
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WFS1 Wolfram syndrome 1 (wolframin)