Glomerulosclerosis, Focal Segmental Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D005923
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Genes

332 genes/proteins associated with the disease Glomerulosclerosis, Focal Segmental from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen 2.88009
HAVCR1 hepatitis A virus cellular receptor 1 2.88009
FN1 fibronectin 1 2.88009
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.88009
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.88009
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.88009
SPP1 secreted phosphoprotein 1 2.88009
INF2 inverted formin, FH2 and WH2 domain containing 2.88009
ZMPSTE24 zinc metallopeptidase STE24 2.88009
TGFB1 transforming growth factor, beta 1 2.88009
MYH10 myosin, heavy chain 10, non-muscle 2.88009
CTGF connective tissue growth factor 2.88009
EDN1 endothelin 1 2.88009
MPV17 MpV17 mitochondrial inner membrane protein 2.88009
COL4A1 collagen, type IV, alpha 1 2.88009
CD2AP CD2-associated protein 2.88009
NOS2 nitric oxide synthase 2, inducible 2.88009
ACTA2 actin, alpha 2, smooth muscle, aorta 2.88009
MYH9 myosin, heavy chain 9, non-muscle 2.88009
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.88009
ACTN4 actinin, alpha 4 2.88009
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.88009
VEGFA vascular endothelial growth factor A 2.26517
BAX BCL2-associated X protein 2.20021
IL6 interleukin 6 2.15386
TNF tumor necrosis factor 2.15306
ICAM1 intercellular adhesion molecule 1 2.13491
BCL2 B-cell CLL/lymphoma 2 2.12344
NPPB natriuretic peptide B 2.11282
VCAM1 vascular cell adhesion molecule 1 2.1062
PPARG peroxisome proliferator-activated receptor gamma 2.10136
CAT catalase 2.09155
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.07301
NPPA natriuretic peptide A 2.06477
IL1B interleukin 1, beta 2.06319
COL1A1 collagen, type I, alpha 1 2.0567
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.03873
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.03741
CCL2 chemokine (C-C motif) ligand 2 2.00829
AGTR2 angiotensin II receptor, type 2 2.00288
CYBA cytochrome b-245, alpha polypeptide 1.99495
NOS3 nitric oxide synthase 3 (endothelial cell) 1.99265
REN renin 1.98482
TIMP1 TIMP metallopeptidase inhibitor 1 1.97023
SOD2 superoxide dismutase 2, mitochondrial 1.95934
ACE angiotensin I converting enzyme 1.9372
MMP2 matrix metallopeptidase 2 1.93201
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.89878
MAPK1 mitogen-activated protein kinase 1 1.8877
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.86739
FASLG Fas ligand (TNF superfamily, member 6) 1.86602
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.8566
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.8566
MAPK3 mitogen-activated protein kinase 3 1.84233
HMOX1 heme oxygenase 1 1.8409
TIMP2 TIMP metallopeptidase inhibitor 2 1.78091
CXCL8 chemokine (C-X-C motif) ligand 8 1.77316
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.7566
COL3A1 collagen, type III, alpha 1 1.7319
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.73129
FOS FBJ murine osteosarcoma viral oncogene homolog 1.71952
NCF1 neutrophil cytosolic factor 1 1.71912
CD36 CD36 molecule (thrombospondin receptor) 1.71912
TP53 tumor protein p53 1.71544
F3 coagulation factor III (thromboplastin, tissue factor) 1.71399
EDNRA endothelin receptor type A 1.68868
MPO myeloperoxidase 1.67462
SOD1 superoxide dismutase 1, soluble 1.67202
ACE2 angiotensin I converting enzyme 2 1.66641
IL10 interleukin 10 1.66468
PPARA peroxisome proliferator-activated receptor alpha 1.66274
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.66081
APOB apolipoprotein B 1.65599
EDNRB endothelin receptor type B 1.63496
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.62938
APOA1 apolipoprotein A-I 1.62601
NOX4 NADPH oxidase 4 1.62579
MMP9 matrix metallopeptidase 9 1.62379
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.61713
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.6036
IFNG interferon, gamma 1.60035
BCL2L1 BCL2-like 1 1.59451
PPARD peroxisome proliferator-activated receptor delta 1.58444
DDIT3 DNA-damage-inducible transcript 3 1.58184
MAPK9 mitogen-activated protein kinase 9 1.56851
IL4 interleukin 4 1.56386
NFE2L2 nuclear factor, erythroid 2-like 2 1.55995
AGTR1 angiotensin II receptor, type 1 1.55971
CYBB cytochrome b-245, beta polypeptide 1.55723
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.55427
AQP2 aquaporin 2 (collecting duct) 1.54888
MAPK8 mitogen-activated protein kinase 8 1.5462
CYCS cytochrome c, somatic 1.54135
ANGPT1 angiopoietin 1 1.53699
FAS Fas cell surface death receptor 1.52363
VIM vimentin 1.51886
IL2 interleukin 2 1.51607
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.5108
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.50953
IGF1 insulin-like growth factor 1 (somatomedin C) 1.50172
CAV1 caveolin 1, caveolae protein, 22kDa 1.49941
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.49252
JUN jun proto-oncogene 1.48633
CCND1 cyclin D1 1.48068
TJP1 tight junction protein 1 1.48068
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.47838
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.47787
PARP1 poly (ADP-ribose) polymerase 1 1.46961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.46858
ALB albumin 1.45484
FSHB follicle stimulating hormone, beta polypeptide 1.43974
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.43591
EGR1 early growth response 1 1.43212
IL1A interleukin 1, alpha 1.42642
APOE apolipoprotein E 1.42047
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.41532
CLU clusterin 1.41478
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.41146
GSK3B glycogen synthase kinase 3 beta 1.41146
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.41035
GSTP1 glutathione S-transferase pi 1 1.41035
CCND2 cyclin D2 1.4026
HSPE1 heat shock 10kDa protein 1 1.38696
FABP4 fatty acid binding protein 4, adipocyte 1.38156
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 1.37275
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.37275
NOS1 nitric oxide synthase 1 (neuronal) 1.35502
NPR1 natriuretic peptide receptor 1 1.35242
CDK2 cyclin-dependent kinase 2 1.35041
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.34547
APP amyloid beta (A4) precursor protein 1.34401
PRKCA protein kinase C, alpha 1.33612
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.33375
EPO erythropoietin 1.33375
KLF5 Kruppel-like factor 5 (intestinal) 1.33199
ANXA2 annexin A2 1.33169
THBS1 thrombospondin 1 1.33169
POMC proopiomelanocortin 1.32074
CCL5 chemokine (C-C motif) ligand 5 1.32074
PLAT plasminogen activator, tissue 1.31387
BAD BCL2-associated agonist of cell death 1.31237
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.31208
TLR4 toll-like receptor 4 1.30941
NCF2 neutrophil cytosolic factor 2 1.30911
HPSE heparanase 1.30696
LEP leptin 1.3036
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.3036
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.29626
TPI1 triosephosphate isomerase 1 1.29564
SELE selectin E 1.29256
TNC tenascin C 1.29041
BIRC5 baculoviral IAP repeat containing 5 1.29041
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.28827
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.27813
LCN2 lipocalin 2 1.27813
FOXO1 forkhead box O1 1.27502
HSPB1 heat shock 27kDa protein 1 1.27193
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.27101
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.26763
GSR glutathione reductase 1.26732
LHB luteinizing hormone beta polypeptide 1.26669
CD44 CD44 molecule (Indian blood group) 1.26576
POSTN periostin, osteoblast specific factor 1.26329
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.26267
NQO1 NAD(P)H dehydrogenase, quinone 1 1.26021
RB1 retinoblastoma 1 1.254
PRKCD protein kinase C, delta 1.24905
ALAS1 5'-aminolevulinate synthase 1 1.24874
AVP arginine vasopressin 1.23743
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.23456
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.23424
VCAN versican 1.23233
LAMC2 laminin, gamma 2 1.23233
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.22821
KDR kinase insert domain receptor 1.22821
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.2279
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.22016
INS insulin 1.21534
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.2137
GPX1 glutathione peroxidase 1 1.21304
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.21173
TIMP3 TIMP metallopeptidase inhibitor 3 1.20946
MKI67 marker of proliferation Ki-67 1.20687
SMAD3 SMAD family member 3 1.20558
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.20361
KNG1 kininogen 1 1.19933
JUNB jun B proto-oncogene 1.19933
SMAD7 SMAD family member 7 1.19802
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.1977
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.19704
IL5 interleukin 5 1.19509
PECAM1 platelet/endothelial cell adhesion molecule 1 1.19509
IL18 interleukin 18 1.19509
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.19379
BDKRB2 bradykinin receptor B2 1.19213
MME membrane metallo-endopeptidase 1.18915
IRS1 insulin receptor substrate 1 1.18554
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.18554
XDH xanthine dehydrogenase 1.18521
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.18391
CCND3 cyclin D3 1.18193
TFRC transferrin receptor 1.17959
PTH1R parathyroid hormone 1 receptor 1.17827
THBD thrombomodulin 1.17794
IL1RN interleukin 1 receptor antagonist 1.17431
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.17431
GPX3 glutathione peroxidase 3 1.17431
ADIPOQ adiponectin, C1Q and collagen domain containing 1.16866
STAR steroidogenic acute regulatory protein 1.166
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.1617
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.1607
PLN phospholamban 1.15661
XBP1 X-box binding protein 1 1.15627
ENO1 enolase 1, (alpha) 1.15593
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.15526
TAC1 tachykinin, precursor 1 1.15526
CTSB cathepsin B 1.15089
LEPR leptin receptor 1.14919
MAPT microtubule-associated protein tau 1.14919
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.14885
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.14644
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.14541
EPAS1 endothelial PAS domain protein 1 1.1437
CPT1A carnitine palmitoyltransferase 1A (liver) 1.1437
C3 complement component 3 1.142
CKB creatine kinase, brain 1.14132
BID BH3 interacting domain death agonist 1.13997
CREM cAMP responsive element modulator 1.13895
GCG glucagon 1.13895
GSTM1 glutathione S-transferase mu 1 1.13586
ATF2 activating transcription factor 2 1.13415
CTSD cathepsin D 1.13211
MGP matrix Gla protein 1.13143
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.13041
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.12906
COL1A2 collagen, type I, alpha 2 1.12703
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.12219
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.12151
IL12B interleukin 12B 1.11809
INSR insulin receptor 1.11775
PLAU plasminogen activator, urokinase 1.11741
MAPK14 mitogen-activated protein kinase 14 1.11571
MBP myelin basic protein 1.11536
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.11396
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.11081
BACE1 beta-site APP-cleaving enzyme 1 1.11046
CASP12 caspase 12 (gene/pseudogene) 1.10872
GNAS GNAS complex locus 1.10872
DUSP10 dual specificity phosphatase 10 1.10699
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.10424
LIPE lipase, hormone-sensitive 1.10388
ADRB2 adrenoceptor beta 2, surface 1.10353
IGFBP3 insulin-like growth factor binding protein 3 1.10317
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.09857
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.09857
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.09716
LDLR low density lipoprotein receptor 1.09576
IGFBP5 insulin-like growth factor binding protein 5 1.09541
LOX lysyl oxidase 1.09541
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.09506
PKP4 plakophilin 4 1.08975
RPS6 ribosomal protein S6 1.0869
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.08478
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.08091
ACAT1 acetyl-CoA acetyltransferase 1 1.08055
CALR calreticulin 1.08055
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.08055
CDKN2A cyclin-dependent kinase inhibitor 2A 1.07804
HSPA8 heat shock 70kDa protein 8 1.07804
MMP1 matrix metallopeptidase 1 1.0766
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.0766
RGS2 regulator of G-protein signaling 2 1.0766
APOC3 apolipoprotein C-III 1.07128
EGFR epidermal growth factor receptor 1.07093
CAPN1 calpain 1, (mu/I) large subunit 1.07093
G6PD glucose-6-phosphate dehydrogenase 1.06808
NRF1 nuclear respiratory factor 1 1.06808
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 1.06698
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.06661
ACHE acetylcholinesterase (Yt blood group) 1.06152
BMP7 bone morphogenetic protein 7 1.06152
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.059
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.05498
GADD45A growth arrest and DNA-damage-inducible, alpha 1.05349
STIP1 stress-induced phosphoprotein 1 1.04978
DES desmin 1.04978
RRM2 ribonucleotide reductase M2 1.04904
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.04684
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 1.04574
CCNB2 cyclin B2 1.04538
MGST1 microsomal glutathione S-transferase 1 1.04352
ODC1 ornithine decarboxylase 1 1.04163
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.04126
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.04088
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.03976
NPY neuropeptide Y 1.03789
TGFB2 transforming growth factor, beta 2 1.03604
PTHLH parathyroid hormone-like hormone 1.03567
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.03567
IGFBP4 insulin-like growth factor binding protein 4 1.0353
CDK4 cyclin-dependent kinase 4 1.03271
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.03235
MAOA monoamine oxidase A 1.03235
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.03122
TH tyrosine hydroxylase 1.03122
EZR ezrin 1.03009
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.03009
HSPA1A heat shock 70kDa protein 1A 1.03009
LDHB lactate dehydrogenase B 1.02746
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.02708
CYC1 cytochrome c-1 1.02671
PCOLCE procollagen C-endopeptidase enhancer 1.02671
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 1.02671
SGK1 serum/glucocorticoid regulated kinase 1 1.02522
POR P450 (cytochrome) oxidoreductase 1.02485
MYLK myosin light chain kinase 1.02447
MMP13 matrix metallopeptidase 13 1.02336
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 1.02225
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 1.02225
VGF VGF nerve growth factor inducible 1.02188
ERN1 endoplasmic reticulum to nucleus signaling 1 1.01928
PMP22 peripheral myelin protein 22 1.01928
CCNE1 cyclin E1 1.01852
IL12A interleukin 12A 1.01814
DLC1 DLC1 Rho GTPase activating protein 1.01739
HSDL2 hydroxysteroid dehydrogenase like 2 1.01739
DPP4 dipeptidyl-peptidase 4 1.01399
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.01361
MGMT O-6-methylguanine-DNA methyltransferase 1.01286
GSTM3 glutathione S-transferase mu 3 (brain) 1.01286
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.01286
EGF epidermal growth factor 1.01099